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(/sup 3/H)Haloperidol labels brain dopamine receptors after its injection into the internal carotid artery of the rat

Journal Article:

Abstract

Pulse injection of (/sup 3/H)haloperidol (0.1 ..mu..Ci; 0.003 ..mu..g) into the internal carotid artery of the rat specifically labelled dopamine receptors in striatum and olfactory tubercle, as indicated by the kinetics of, and the effects of neuroleptic drugs on, the ligand disposition. The described method may prove useful for labelling brain receptors with ligands which readily cross the blood-brain barrier but which do not selectively mark their receptors if injected systemically.
Authors:
D'Ambrosio, A; Zivkovic, B; Bartholini, G [1] 
  1. Research Department, Synthelabo-L.E.R.S., Paris (France)
Publication Date:
Apr 29, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-695887; EDB-82-165798
Resource Relation:
Journal Name: Brain Res.; (Netherlands); Journal Volume: 238:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; RECEPTORS; LABELLING; BLOOD-BRAIN BARRIER; DOPAMINE; INTRAVENOUS INJECTION; LIGANDS; RADIONUCLIDE KINETICS; RATS; SPATIAL DISTRIBUTION; TRITIUM COMPOUNDS; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DISTRIBUTION; DRUGS; HYDROXY COMPOUNDS; INJECTION; INTAKE; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RODENTS; SYMPATHOMIMETICS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
6781411
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BRREA
Submitting Site:
HEDB
Size:
Pages: 470-474
Announcement Date:
Sep 01, 1982

Journal Article:

Citation Formats

D'Ambrosio, A, Zivkovic, B, and Bartholini, G. (/sup 3/H)Haloperidol labels brain dopamine receptors after its injection into the internal carotid artery of the rat. Netherlands: N. p., 1982. Web.
D'Ambrosio, A, Zivkovic, B, & Bartholini, G. (/sup 3/H)Haloperidol labels brain dopamine receptors after its injection into the internal carotid artery of the rat. Netherlands.
D'Ambrosio, A, Zivkovic, B, and Bartholini, G. 1982. "(/sup 3/H)Haloperidol labels brain dopamine receptors after its injection into the internal carotid artery of the rat." Netherlands.
@misc{etde_6781411,
title = {(/sup 3/H)Haloperidol labels brain dopamine receptors after its injection into the internal carotid artery of the rat}
author = {D'Ambrosio, A, Zivkovic, B, and Bartholini, G}
abstractNote = {Pulse injection of (/sup 3/H)haloperidol (0.1 ..mu..Ci; 0.003 ..mu..g) into the internal carotid artery of the rat specifically labelled dopamine receptors in striatum and olfactory tubercle, as indicated by the kinetics of, and the effects of neuroleptic drugs on, the ligand disposition. The described method may prove useful for labelling brain receptors with ligands which readily cross the blood-brain barrier but which do not selectively mark their receptors if injected systemically.}
journal = {Brain Res.; (Netherlands)}
volume = {238:2}
journal type = {AC}
place = {Netherlands}
year = {1982}
month = {Apr}
}