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Nuclear magnetic resonance studies on brain edema. Time course of /sup 1/H-NMR relaxation times

Journal Article:

Abstract

1. The state of water in normal and edematous brain tissue was studied by measurement of proton longitudinal (T/sub 1/) and transverse (T/sub 2/) relaxation times using pulsed nuclear magnetic resonance (NMR) technique. 2. In control rats, T/sub 1/ and T/sub 2/ of water showed one component, which was more fast in white matter. Those values displayed 1.07 - 1.18 sec. of T/sub 1/ and 75 - 76 msec. of T/sub 2/. 3. When rat brain was injured by cold, T/sub 1/ was observed to become longer (1.18 - 1.27 sec.), and T/sub 2/ was observed be separated into two components, the faster T/sub 2/ (45 - 50 msec.) and slower T/sub 2/ (100 - 105 msec.), in both gray and white matter of the injured side. 4. In triethyltin (TET) induced brain edema, elongation of T/sub 1/ (1.2 sec.) and remarkable separation of T/sub 2/, faster T/sub 2/ (75 msec.) and slower T/sub 2/ (400 - 450 msec.), were observed in white matter. 5. In both cold and TET induced edema, slower T/sub 2/ fraction is suggested to be the extracellular space and faster T/sub 2/ fraction, intracellular. 6. T/sub 2/ changes precede the water content changes in cold  More>>
Authors:
Naruse, S; Horikawa, Y; Tanaka, C; Hirakawa, K; Nishikawa, H [1] 
  1. Kyoto Prefectural Univ. of Medicine (Japan)
Publication Date:
Jun 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-695922; EDB-82-166364
Resource Relation:
Journal Name: No To Shinkei; (Japan); Journal Volume: 33:6
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; EDEMA; NUCLEAR MAGNETIC RESONANCE; DIAGNOSTIC USES; BODY FLUIDS; CEREBRUM; DIAGNOSIS; DYNAMIC FUNCTION STUDIES; EXTRACELLULAR SPACE; PATHOLOGY; QUANTITY RATIO; RATS; RELAXATION; TIME DEPENDENCE; ANIMALS; BIOLOGICAL MATERIALS; BODY; CENTRAL NERVOUS SYSTEM; MAGNETIC RESONANCE; MAMMALS; MATERIALS; NERVOUS SYSTEM; ORGANS; PATHOLOGICAL CHANGES; RESONANCE; RODENTS; SPACE; SYMPTOMS; USES; VERTEBRATES; 550900* - Pathology; 550600 - Medicine
OSTI ID:
6778953
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NOTOA
Submitting Site:
HEDB
Size:
Pages: 569-575
Announcement Date:

Journal Article:

Citation Formats

Naruse, S, Horikawa, Y, Tanaka, C, Hirakawa, K, and Nishikawa, H. Nuclear magnetic resonance studies on brain edema. Time course of /sup 1/H-NMR relaxation times. Japan: N. p., 1981. Web.
Naruse, S, Horikawa, Y, Tanaka, C, Hirakawa, K, & Nishikawa, H. Nuclear magnetic resonance studies on brain edema. Time course of /sup 1/H-NMR relaxation times. Japan.
Naruse, S, Horikawa, Y, Tanaka, C, Hirakawa, K, and Nishikawa, H. 1981. "Nuclear magnetic resonance studies on brain edema. Time course of /sup 1/H-NMR relaxation times." Japan.
@misc{etde_6778953,
title = {Nuclear magnetic resonance studies on brain edema. Time course of /sup 1/H-NMR relaxation times}
author = {Naruse, S, Horikawa, Y, Tanaka, C, Hirakawa, K, and Nishikawa, H}
abstractNote = {1. The state of water in normal and edematous brain tissue was studied by measurement of proton longitudinal (T/sub 1/) and transverse (T/sub 2/) relaxation times using pulsed nuclear magnetic resonance (NMR) technique. 2. In control rats, T/sub 1/ and T/sub 2/ of water showed one component, which was more fast in white matter. Those values displayed 1.07 - 1.18 sec. of T/sub 1/ and 75 - 76 msec. of T/sub 2/. 3. When rat brain was injured by cold, T/sub 1/ was observed to become longer (1.18 - 1.27 sec.), and T/sub 2/ was observed be separated into two components, the faster T/sub 2/ (45 - 50 msec.) and slower T/sub 2/ (100 - 105 msec.), in both gray and white matter of the injured side. 4. In triethyltin (TET) induced brain edema, elongation of T/sub 1/ (1.2 sec.) and remarkable separation of T/sub 2/, faster T/sub 2/ (75 msec.) and slower T/sub 2/ (400 - 450 msec.), were observed in white matter. 5. In both cold and TET induced edema, slower T/sub 2/ fraction is suggested to be the extracellular space and faster T/sub 2/ fraction, intracellular. 6. T/sub 2/ changes precede the water content changes in cold injury, and parallel in TET induced edema. Those changes of relaxation times are reversible. 7. T/sub 2/ changes of water is more sensitive than the T/sub 1/ for the detection of production and disappearance of brain edema. 8. These results disclose the dynamic movements of water during the course of brain edema and offered significant information of the clinical application of NMR-CT.}
journal = {No To Shinkei; (Japan)}
volume = {33:6}
journal type = {AC}
place = {Japan}
year = {1981}
month = {Jun}
}