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Protective effects of vitamin E on microcephaly in rats X-irradiated in utero: DNA, lipid peroxide and confronting cisternae

Abstract

Fetuses from rats given either water or 0.03% D,L-..cap alpha..-tocopherol acetate (vitamin E) as a drinking fluid and X-irradiated with 100 rad on gestational day 13 were examined on gestational day 21. Mean cerebral weight which was significantly reduced by the X-irradiation was increased by vitamin E supplementation but the level did not reach that in sham-irradiated controls. Administration of vitamin E caused an increase in DNA concentration which was significantly reduced by X-irradiation with water treatment. An increase in the mean level of lipid peroxide formation was observed in the water-treated, X-irradiated group in the sample at zero time but not in the vitamin E-treated, X-irradiated group. In the cytoplasm of fetal cerebral neurons from X-irradiated dams with vitamin E supplementation, confronting cisternae were frequently observed between two nuclear envelopes. Confronting cisternae may be considered as a repair mechanism of vitamin E against X-irradiated neuronal damage in the fetal cerebrum. This study provides evidence of the protection by vitamin E of neuronal development in X-irradiated fetuses, through its antioxidant properties, against attacks by free radicals and/or lipid peroxide. 35 refs.; 3 figs.; 1 table.
Publication Date:
Jun 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-18-027406; EDB-87-050169
Resource Relation:
Journal Name: Dev. Brain Res.; (Netherlands); Journal Volume: 27:1-2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; VITAMIN E; BIOLOGICAL REPAIR; RADIOPROTECTIVE SUBSTANCES; ANTIOXIDANTS; BIOLOGICAL RADIATION EFFECTS; FETUSES; MALFORMATIONS; RATS; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RODENTS; VERTEBRATES; VITAMINS; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6776020
Research Organizations:
National Center for Nervous, Mental and Muscular Disorders, Tokyo, Japan. Division of Mental Retardation and Birth Defect Research; Toho Univ., Tokyo, Japan. School of Medicine
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: DBRRD
Submitting Site:
INIS
Size:
Pages: 11-17
Announcement Date:

Citation Formats

Tanaka, Harumi, Iwasaki, Setsuo, Inomata, Kenichirou, Nasu, Fumio, and Nishimura, Shigeru. Protective effects of vitamin E on microcephaly in rats X-irradiated in utero: DNA, lipid peroxide and confronting cisternae. Netherlands: N. p., 1986. Web. doi:10.1016/0165-3806(86)90227-0.
Tanaka, Harumi, Iwasaki, Setsuo, Inomata, Kenichirou, Nasu, Fumio, & Nishimura, Shigeru. Protective effects of vitamin E on microcephaly in rats X-irradiated in utero: DNA, lipid peroxide and confronting cisternae. Netherlands. doi:10.1016/0165-3806(86)90227-0.
Tanaka, Harumi, Iwasaki, Setsuo, Inomata, Kenichirou, Nasu, Fumio, and Nishimura, Shigeru. 1986. "Protective effects of vitamin E on microcephaly in rats X-irradiated in utero: DNA, lipid peroxide and confronting cisternae." Netherlands. doi:10.1016/0165-3806(86)90227-0. https://www.osti.gov/servlets/purl/10.1016/0165-3806(86)90227-0.
@misc{etde_6776020,
title = {Protective effects of vitamin E on microcephaly in rats X-irradiated in utero: DNA, lipid peroxide and confronting cisternae}
author = {Tanaka, Harumi, Iwasaki, Setsuo, Inomata, Kenichirou, Nasu, Fumio, and Nishimura, Shigeru}
abstractNote = {Fetuses from rats given either water or 0.03% D,L-..cap alpha..-tocopherol acetate (vitamin E) as a drinking fluid and X-irradiated with 100 rad on gestational day 13 were examined on gestational day 21. Mean cerebral weight which was significantly reduced by the X-irradiation was increased by vitamin E supplementation but the level did not reach that in sham-irradiated controls. Administration of vitamin E caused an increase in DNA concentration which was significantly reduced by X-irradiation with water treatment. An increase in the mean level of lipid peroxide formation was observed in the water-treated, X-irradiated group in the sample at zero time but not in the vitamin E-treated, X-irradiated group. In the cytoplasm of fetal cerebral neurons from X-irradiated dams with vitamin E supplementation, confronting cisternae were frequently observed between two nuclear envelopes. Confronting cisternae may be considered as a repair mechanism of vitamin E against X-irradiated neuronal damage in the fetal cerebrum. This study provides evidence of the protection by vitamin E of neuronal development in X-irradiated fetuses, through its antioxidant properties, against attacks by free radicals and/or lipid peroxide. 35 refs.; 3 figs.; 1 table.}
doi = {10.1016/0165-3806(86)90227-0}
journal = {Dev. Brain Res.; (Netherlands)}
volume = {27:1-2}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {Jun}
}