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Striatal kinetics of ( sup 11 C)-(+)-nomifensine and 6-( sup 18 F)fluoro-L-dopa in Parkinson's disease measured with positron emission tomography

Journal Article:

Abstract

The kinetics in brain of the dopamine reuptake blocking agent ({sup 11}C)-(+)-nomifensine and the L-dopa analogue 6-({sup 18}F)fluoro-L-dopa were compared in 3 patients with idopathic Parkinson's disease and agematched healthy volunteers using positron emission tomography. Regional uptake was analyzed and quantified according to a 3-compartment model. Retention of both tracers in striatal regions of the parkinsonian patients were reduced compared with the healthy volunteers mainly in the putamen, while the caudate nuclleus was only mildly affected. The reductions were considerably less than the decrease previously reported postmortem for striatal dopamine content in the basal ganglia of patients with Parkinson's disease. A fairly constant ratio between 6-({sup 18}F)fluoro-L-dopa utilization and ({sup 11}C)-(+)-nomifensine binding in the caudate nucleus and the putamen were found in both groups unrelated to the size of the estimated parameters. This indicates that a limiting factor for the utilization of exogenous levodopa in Parkinsons's disease may be a reduced transport capacity for the amino acid into the dopaminergic terminals. (author).
Authors:
Tedroff, J; Aquilonius, S -M; [1]  Laihinen, A; Rinne, U; [2]  Hartvig, P; [3]  Anderson, J; [4]  Lundqvist, H; [5]  Haaparanta, M; Solin, O; [6]  Antoni, G; Gee, A D; Ulin, J; Laangstroem, B [7] 
  1. Department of Neurology, University Hospital (Sweden)
  2. Department of Neurology, University of Turku (Finland)
  3. Department of Hospital Pharmacy, University Hospital (Sweden)
  4. Department of Radiation Sciences, University Hospital (Sweden)
  5. Svenberg Laboratory, Uppsala University (Sweden)
  6. Medical Cyclotron Laboratory, University of Turku (Finland)
  7. Department of Organic Chemistry, University Hospital (Sweden)
Publication Date:
Jan 01, 1990
Product Type:
Journal Article
Reference Number:
AIX-21-058303; EDB-90-112855
Resource Relation:
Journal Name: Acta Neurologica Scandinavica; (Denmark); Journal Volume: 81
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; BRAIN; POSITRON COMPUTED TOMOGRAPHY; DOPA; FLUORINE 18; CARBON 11; CHEMICAL PREPARATION; LABELLED COMPOUNDS; NERVOUS SYSTEM DISEASES; RECEPTORS; RETENTION; AMINO ACIDS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man; 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production
OSTI ID:
6772083
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0001-6314; CODEN: ANRSA
Submitting Site:
DKN
Size:
Pages: 81
Announcement Date:

Journal Article:

Citation Formats

Tedroff, J, Aquilonius, S -M, Laihinen, A, Rinne, U, Hartvig, P, Anderson, J, Lundqvist, H, Haaparanta, M, Solin, O, Antoni, G, Gee, A D, Ulin, J, and Laangstroem, B. Striatal kinetics of ( sup 11 C)-(+)-nomifensine and 6-( sup 18 F)fluoro-L-dopa in Parkinson's disease measured with positron emission tomography. Denmark: N. p., 1990. Web.
Tedroff, J, Aquilonius, S -M, Laihinen, A, Rinne, U, Hartvig, P, Anderson, J, Lundqvist, H, Haaparanta, M, Solin, O, Antoni, G, Gee, A D, Ulin, J, & Laangstroem, B. Striatal kinetics of ( sup 11 C)-(+)-nomifensine and 6-( sup 18 F)fluoro-L-dopa in Parkinson's disease measured with positron emission tomography. Denmark.
Tedroff, J, Aquilonius, S -M, Laihinen, A, Rinne, U, Hartvig, P, Anderson, J, Lundqvist, H, Haaparanta, M, Solin, O, Antoni, G, Gee, A D, Ulin, J, and Laangstroem, B. 1990. "Striatal kinetics of ( sup 11 C)-(+)-nomifensine and 6-( sup 18 F)fluoro-L-dopa in Parkinson's disease measured with positron emission tomography." Denmark.
@misc{etde_6772083,
title = {Striatal kinetics of ( sup 11 C)-(+)-nomifensine and 6-( sup 18 F)fluoro-L-dopa in Parkinson's disease measured with positron emission tomography}
author = {Tedroff, J, Aquilonius, S -M, Laihinen, A, Rinne, U, Hartvig, P, Anderson, J, Lundqvist, H, Haaparanta, M, Solin, O, Antoni, G, Gee, A D, Ulin, J, and Laangstroem, B}
abstractNote = {The kinetics in brain of the dopamine reuptake blocking agent ({sup 11}C)-(+)-nomifensine and the L-dopa analogue 6-({sup 18}F)fluoro-L-dopa were compared in 3 patients with idopathic Parkinson's disease and agematched healthy volunteers using positron emission tomography. Regional uptake was analyzed and quantified according to a 3-compartment model. Retention of both tracers in striatal regions of the parkinsonian patients were reduced compared with the healthy volunteers mainly in the putamen, while the caudate nuclleus was only mildly affected. The reductions were considerably less than the decrease previously reported postmortem for striatal dopamine content in the basal ganglia of patients with Parkinson's disease. A fairly constant ratio between 6-({sup 18}F)fluoro-L-dopa utilization and ({sup 11}C)-(+)-nomifensine binding in the caudate nucleus and the putamen were found in both groups unrelated to the size of the estimated parameters. This indicates that a limiting factor for the utilization of exogenous levodopa in Parkinsons's disease may be a reduced transport capacity for the amino acid into the dopaminergic terminals. (author).}
journal = {Acta Neurologica Scandinavica; (Denmark)}
volume = {81}
journal type = {AC}
place = {Denmark}
year = {1990}
month = {Jan}
}