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Coding sequence of human rho cDNAs clone 6 and clone 9

Journal Article:

Abstract

The authors have isolated human cDNAs including the complete coding sequence for two rho proteins corresponding to the incomplete isolates previously described as clone 6 and clone 9. The deduced a.a. sequences, when compared to the a.a. sequence deduced from clone 12 cDNA, show that there are in human at least three highly homologous rho genes. They suggest that clone 12 be named rhoA, clone 6 : rhoB and clone 9 : rhoC. RhoA, B and C proteins display approx. 30% a.a. identity with ras proteins,. mainly clustered in four highly homologous internal regions corresponding to the GTP binding site; however at least one significant difference is found; the 3 rho proteins have an Alanine in position corresponding to ras Glycine 13, suggesting that rho and ras proteins might have slightly different biochemical properties.
Publication Date:
Mar 25, 1988
Product Type:
Journal Article
Reference Number:
EDB-88-172336
Resource Relation:
Journal Name: Nucleic Acids Res.; (United Kingdom); Journal Volume: 16:6
Subject:
59 BASIC BIOLOGICAL SCIENCES; PROTEINS; AMINO ACID SEQUENCE; RECOMBINANT DNA; DNA SEQUENCING; ALANINES; BIOCHEMISTRY; DNA-CLONING; GLYCINE; MAN; AMINO ACIDS; ANIMALS; CARBOXYLIC ACIDS; CHEMISTRY; CLONING; DNA; MAMMALS; MOLECULAR STRUCTURE; NUCLEIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; PRIMATES; STRUCTURAL CHEMICAL ANALYSIS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
6771555
Research Organizations:
INSERM, Paris (France)
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NARHA
Submitting Site:
JMT
Size:
Pages: 2717
Announcement Date:
Oct 01, 1988

Journal Article:

Citation Formats

Chardin, P, Madaule, P, and Tavitian, A. Coding sequence of human rho cDNAs clone 6 and clone 9. United Kingdom: N. p., 1988. Web. doi:10.1093/nar/16.6.2717.
Chardin, P, Madaule, P, & Tavitian, A. Coding sequence of human rho cDNAs clone 6 and clone 9. United Kingdom. doi:10.1093/nar/16.6.2717.
Chardin, P, Madaule, P, and Tavitian, A. 1988. "Coding sequence of human rho cDNAs clone 6 and clone 9." United Kingdom. doi:10.1093/nar/16.6.2717. https://www.osti.gov/servlets/purl/10.1093/nar/16.6.2717.
@misc{etde_6771555,
title = {Coding sequence of human rho cDNAs clone 6 and clone 9}
author = {Chardin, P, Madaule, P, and Tavitian, A}
abstractNote = {The authors have isolated human cDNAs including the complete coding sequence for two rho proteins corresponding to the incomplete isolates previously described as clone 6 and clone 9. The deduced a.a. sequences, when compared to the a.a. sequence deduced from clone 12 cDNA, show that there are in human at least three highly homologous rho genes. They suggest that clone 12 be named rhoA, clone 6 : rhoB and clone 9 : rhoC. RhoA, B and C proteins display approx. 30% a.a. identity with ras proteins,. mainly clustered in four highly homologous internal regions corresponding to the GTP binding site; however at least one significant difference is found; the 3 rho proteins have an Alanine in position corresponding to ras Glycine 13, suggesting that rho and ras proteins might have slightly different biochemical properties.}
doi = {10.1093/nar/16.6.2717}
journal = {Nucleic Acids Res.; (United Kingdom)}
volume = {16:6}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Mar}
}