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Reclassification of leukemia among A-bomb survivors in Nagasaki using French-American-British (FAB) classification for acute leukemia

Journal Article:

Abstract

The concordance rate for diagnoses of atomic bomb-related cases of leukemia in Nagasaki was determined using the French-American-British (FAB) classification for acute leukemias and myelodysplastic syndromes (MDS). Two Radiation Effects Research Foundation (RERF) hematologists and one of the members (JMB) of the FAB cooperative group reviewed independently the peripheral blood and/or bone marrow smears from 193 people with leukemia or a related disorder. There was 85 % agreement in the identification of types and subtypes of acute leukemia. There was almost complete agreement for the diagnoses of non-FAB disorders (chronic myeloid leukemia (CML), adult T-cell leukemia (ATL) and others) resulting in overall concordance of 88.2 %. The present study suggest that the previously established leukemia types for about a quarter of the cases of acute leukemia and related disorders except CML should be changed. Considerable numbers of cases of ATL and MDS were involved in this series. The frequency of the former disease was not high in the high-dose irradiated group, but that of the latter was considerably high. All subtypes of AML except M3 and M6 were present in the high-dose group. The striking difference in CML incidence between Nagasaki and Hiroshima may continue to be a problem in  More>>
Publication Date:
Jun 01, 1988
Product Type:
Journal Article
Reference Number:
JPN-88-082145; EDB-88-180156
Resource Relation:
Journal Name: Jpn. J. Clin. Oncol.; (Japan); Journal Volume: 18:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; LEUKEMIA; BLOOD CELLS; BONE MARROW; DELAYED RADIATION EFFECTS; NAGASAKI; RADIATION DOSES; ANIMAL TISSUES; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; DISEASES; DOSES; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; HUMAN POPULATIONS; IMMUNE SYSTEM DISEASES; JAPAN; MATERIALS; NEOPLASMS; ORGANS; POPULATIONS; RADIATION EFFECTS; TISSUES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6765872
Research Organizations:
Radiation Effects Research Foundation, Hiroshima (Japan)
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JJCOA
Submitting Site:
JPN
Size:
Pages: 91-96
Announcement Date:

Journal Article:

Citation Formats

Matsuo, Tatsuki, Tomonaga, Masao, and Bennett, J.M. and others. Reclassification of leukemia among A-bomb survivors in Nagasaki using French-American-British (FAB) classification for acute leukemia. Japan: N. p., 1988. Web.
Matsuo, Tatsuki, Tomonaga, Masao, & Bennett, J.M. and others. Reclassification of leukemia among A-bomb survivors in Nagasaki using French-American-British (FAB) classification for acute leukemia. Japan.
Matsuo, Tatsuki, Tomonaga, Masao, and Bennett, J.M. and others. 1988. "Reclassification of leukemia among A-bomb survivors in Nagasaki using French-American-British (FAB) classification for acute leukemia." Japan.
@misc{etde_6765872,
title = {Reclassification of leukemia among A-bomb survivors in Nagasaki using French-American-British (FAB) classification for acute leukemia}
author = {Matsuo, Tatsuki, Tomonaga, Masao, and Bennett, J.M. and others}
abstractNote = {The concordance rate for diagnoses of atomic bomb-related cases of leukemia in Nagasaki was determined using the French-American-British (FAB) classification for acute leukemias and myelodysplastic syndromes (MDS). Two Radiation Effects Research Foundation (RERF) hematologists and one of the members (JMB) of the FAB cooperative group reviewed independently the peripheral blood and/or bone marrow smears from 193 people with leukemia or a related disorder. There was 85 % agreement in the identification of types and subtypes of acute leukemia. There was almost complete agreement for the diagnoses of non-FAB disorders (chronic myeloid leukemia (CML), adult T-cell leukemia (ATL) and others) resulting in overall concordance of 88.2 %. The present study suggest that the previously established leukemia types for about a quarter of the cases of acute leukemia and related disorders except CML should be changed. Considerable numbers of cases of ATL and MDS were involved in this series. The frequency of the former disease was not high in the high-dose irradiated group, but that of the latter was considerably high. All subtypes of AML except M3 and M6 were present in the high-dose group. The striking difference in CML incidence between Nagasaki and Hiroshima may continue to be a problem in relation to biological response to radiation exposure.}
journal = {Jpn. J. Clin. Oncol.; (Japan)}
volume = {18:2}
journal type = {AC}
place = {Japan}
year = {1988}
month = {Jun}
}