Abstract
The somatomedins (IGF-1/IGF-2) are a family of growth-promoting hormones which have been identified in the human central nervous system where their specific receptors are distributed. The present study identified somatomedin receptors in glioblastoma and compared them with those found in normal brain. A significant enhancement in the binding of /sup 125/1-IGF-2 but not /sup 125/1-IGF-1 to glioblastoma membranes was found. A fourfold increase in IGF-2 receptor concentration was observed. These findings indicate enhanced expression of the IGF-2 receptor in glioblastoma. 14 refs.
Citation Formats
Sara, V, Prisell, P, Sjoegren, B, Persson, L, Boethius, J, and Enberg, G.
Enhancement of insulin-like growth factor 2 receptors in glioblastoma.
Ireland: N. p.,
1986.
Web.
doi:10.1016/0304-3835(86)90174-6.
Sara, V, Prisell, P, Sjoegren, B, Persson, L, Boethius, J, & Enberg, G.
Enhancement of insulin-like growth factor 2 receptors in glioblastoma.
Ireland.
https://doi.org/10.1016/0304-3835(86)90174-6
Sara, V, Prisell, P, Sjoegren, B, Persson, L, Boethius, J, and Enberg, G.
1986.
"Enhancement of insulin-like growth factor 2 receptors in glioblastoma."
Ireland.
https://doi.org/10.1016/0304-3835(86)90174-6.
@misc{etde_6764162,
title = {Enhancement of insulin-like growth factor 2 receptors in glioblastoma}
author = {Sara, V, Prisell, P, Sjoegren, B, Persson, L, Boethius, J, and Enberg, G}
abstractNote = {The somatomedins (IGF-1/IGF-2) are a family of growth-promoting hormones which have been identified in the human central nervous system where their specific receptors are distributed. The present study identified somatomedin receptors in glioblastoma and compared them with those found in normal brain. A significant enhancement in the binding of /sup 125/1-IGF-2 but not /sup 125/1-IGF-1 to glioblastoma membranes was found. A fourfold increase in IGF-2 receptor concentration was observed. These findings indicate enhanced expression of the IGF-2 receptor in glioblastoma. 14 refs.}
doi = {10.1016/0304-3835(86)90174-6}
journal = []
volume = {32:3}
journal type = {AC}
place = {Ireland}
year = {1986}
month = {Sep}
}
title = {Enhancement of insulin-like growth factor 2 receptors in glioblastoma}
author = {Sara, V, Prisell, P, Sjoegren, B, Persson, L, Boethius, J, and Enberg, G}
abstractNote = {The somatomedins (IGF-1/IGF-2) are a family of growth-promoting hormones which have been identified in the human central nervous system where their specific receptors are distributed. The present study identified somatomedin receptors in glioblastoma and compared them with those found in normal brain. A significant enhancement in the binding of /sup 125/1-IGF-2 but not /sup 125/1-IGF-1 to glioblastoma membranes was found. A fourfold increase in IGF-2 receptor concentration was observed. These findings indicate enhanced expression of the IGF-2 receptor in glioblastoma. 14 refs.}
doi = {10.1016/0304-3835(86)90174-6}
journal = []
volume = {32:3}
journal type = {AC}
place = {Ireland}
year = {1986}
month = {Sep}
}