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Total body neutron activation analysis of calcium: calibration and normalisation

Abstract

An irradiation system has been designed, using a neutron beam from a cyclotron, which optimises the uniformity of activation of calcium. Induced activity is measured in a scanning, shadow-shield whole-body counter. Calibration has been effected and reproducibility assessed with three different types of phantom. Corrections were derived for variations in body height, depth and fat thickness. The coefficient of variation for repeated measurements of an anthropomorphic phantom was 1.8% for an absorbed dose equivalent of 13 mSv (1.3 rem). Measurements of total body calcium in 40 normal adults were used to derive normalisation factors which predict the normal calcium in a subject of given size and age. The coefficient of variation of normalised calcium was 6.2% in men and 6.6% in women, with the demonstration of an annual loss of 1.5% after the menopause. The narrow range should make single measurements useful for diagnostic purposes.
Authors:
Kennedy, N S.J.; Eastell, R; Ferrington, C M; Simpson, J D; Strong, J A; [1]  Smith, M A; Tothill, P [2] 
  1. Western General Hospital, Edinburgh (UK)
  2. Royal Infirmary, Edinburgh (UK)
Publication Date:
May 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-699403; EDB-82-178837
Resource Relation:
Journal Name: Phys. Med. Biol.; (United Kingdom); Journal Volume: 27:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY; CALCIUM; ACTIVATION ANALYSIS; AGE DEPENDENCE; CALIBRATION; CORRECTIONS; DIAGNOSTIC TECHNIQUES; DOSE EQUIVALENTS; ERRORS; NEUTRON REACTIONS; OPTIMIZATION; PHANTOMS; WHOLE-BODY COUNTING; ALKALINE EARTH METALS; BARYON REACTIONS; CHEMICAL ANALYSIS; COUNTING TECHNIQUES; ELEMENTS; HADRON REACTIONS; METALS; MOCKUP; NUCLEAR REACTIONS; NUCLEON REACTIONS; STRUCTURAL MODELS; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 655003 - Medical Physics- Dosimetry
OSTI ID:
6758725
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PHMBA
Submitting Site:
HEDB
Size:
Pages: 697-707
Announcement Date:

Citation Formats

Kennedy, N S.J., Eastell, R, Ferrington, C M, Simpson, J D, Strong, J A, Smith, M A, and Tothill, P. Total body neutron activation analysis of calcium: calibration and normalisation. United Kingdom: N. p., 1982. Web. doi:10.1088/0031-9155/27/5/004.
Kennedy, N S.J., Eastell, R, Ferrington, C M, Simpson, J D, Strong, J A, Smith, M A, & Tothill, P. Total body neutron activation analysis of calcium: calibration and normalisation. United Kingdom. doi:10.1088/0031-9155/27/5/004.
Kennedy, N S.J., Eastell, R, Ferrington, C M, Simpson, J D, Strong, J A, Smith, M A, and Tothill, P. 1982. "Total body neutron activation analysis of calcium: calibration and normalisation." United Kingdom. doi:10.1088/0031-9155/27/5/004. https://www.osti.gov/servlets/purl/10.1088/0031-9155/27/5/004.
@misc{etde_6758725,
title = {Total body neutron activation analysis of calcium: calibration and normalisation}
author = {Kennedy, N S.J., Eastell, R, Ferrington, C M, Simpson, J D, Strong, J A, Smith, M A, and Tothill, P}
abstractNote = {An irradiation system has been designed, using a neutron beam from a cyclotron, which optimises the uniformity of activation of calcium. Induced activity is measured in a scanning, shadow-shield whole-body counter. Calibration has been effected and reproducibility assessed with three different types of phantom. Corrections were derived for variations in body height, depth and fat thickness. The coefficient of variation for repeated measurements of an anthropomorphic phantom was 1.8% for an absorbed dose equivalent of 13 mSv (1.3 rem). Measurements of total body calcium in 40 normal adults were used to derive normalisation factors which predict the normal calcium in a subject of given size and age. The coefficient of variation of normalised calcium was 6.2% in men and 6.6% in women, with the demonstration of an annual loss of 1.5% after the menopause. The narrow range should make single measurements useful for diagnostic purposes.}
doi = {10.1088/0031-9155/27/5/004}
journal = {Phys. Med. Biol.; (United Kingdom)}
volume = {27:5}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {May}
}