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Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow

Abstract

We have previously reported attempts to reestablish the chronic phase of chronic granulocytic leukemia (CGL), in two patients with blastic transrormation, utilizing intensive therapy followed by the infusion of cryopreserved autologous marrow. This approach has now been attempted in a total of seven patients. Marrow was harvested on single or multiple occasions during the chronic phase of CGL and cryopreserved in 10% dimethylsulfoxide. All patients were treated with cyclophosphamide, 120 mg/kg, plus 1,000 rad of total body irradiation followed by infusion of stored marrow. Two patients failed to achieve marrow repopulation and died of infection after 29 and 48 days. Three patients had partial marrow recovery. Two of these achieved repopulation of myeloid, erythroid, and lymphoid elements but did not recover platelet function; one died of hemorrhage on day 55, and one died of cytomegalovirus interstitial pneumonitis on day 58. A third patient had delayed engraftment of all cell elements, most prominently lymphocytes, and died after 84 days of an iodopathic interstitial pneumonitis. Two patients achieved prompt and complete reestablishment of the chronic phase of CGL. One died on day 72 with a fungal pheumonitis and one developed blastic transformation within 4 months. These preliminary results indicate that this approach  More>>
Publication Date:
Jan 01, 1978
Product Type:
Conference
Reference Number:
AIX-09-373563; EDB-78-104999
Resource Relation:
Journal Name: Exp. Hematol.; (Denmark); Journal Volume: 6; Conference: 4. annual meeting of the International Society for Experimental Hematology, Trogir, Yugoslavia, 21 - 25 Sep 1975
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHEMOTHERAPY; SIDE EFFECTS; LEUKEMIA; RADIOTHERAPY; BONE MARROW; ENDOXAN; PATIENTS; PNEUMONITIS; WHOLE-BODY IRRADIATION; ALKYLATING AGENTS; ANTIMITOTIC DRUGS; BODY; DISEASES; DRUGS; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY; TISSUES; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6754924
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXHEB
Submitting Site:
INIS
Size:
Pages: 96-109
Announcement Date:

Citation Formats

Buckner, C D, Stewart, P, Clift, R A, Fefer, A, Neiman, P E, Singer, J, Storb, R, Thomas, E D, The United States Public Health Service Hospital, and Providence Medical Center, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA). Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow. Denmark: N. p., 1978. Web.
Buckner, C D, Stewart, P, Clift, R A, Fefer, A, Neiman, P E, Singer, J, Storb, R, Thomas, E D, The United States Public Health Service Hospital, & Providence Medical Center, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA). Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow. Denmark.
Buckner, C D, Stewart, P, Clift, R A, Fefer, A, Neiman, P E, Singer, J, Storb, R, Thomas, E D, The United States Public Health Service Hospital, and Providence Medical Center, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA). 1978. "Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow." Denmark.
@misc{etde_6754924,
title = {Treatment of blastic transformation of chronic granulocytic leukemia by chemotherapy, total body irradiation and infusion of cryopreserved autologous marrow}
author = {Buckner, C D, Stewart, P, Clift, R A, Fefer, A, Neiman, P E, Singer, J, Storb, R, Thomas, E D, The United States Public Health Service Hospital, and Providence Medical Center, and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA)}
abstractNote = {We have previously reported attempts to reestablish the chronic phase of chronic granulocytic leukemia (CGL), in two patients with blastic transrormation, utilizing intensive therapy followed by the infusion of cryopreserved autologous marrow. This approach has now been attempted in a total of seven patients. Marrow was harvested on single or multiple occasions during the chronic phase of CGL and cryopreserved in 10% dimethylsulfoxide. All patients were treated with cyclophosphamide, 120 mg/kg, plus 1,000 rad of total body irradiation followed by infusion of stored marrow. Two patients failed to achieve marrow repopulation and died of infection after 29 and 48 days. Three patients had partial marrow recovery. Two of these achieved repopulation of myeloid, erythroid, and lymphoid elements but did not recover platelet function; one died of hemorrhage on day 55, and one died of cytomegalovirus interstitial pneumonitis on day 58. A third patient had delayed engraftment of all cell elements, most prominently lymphocytes, and died after 84 days of an iodopathic interstitial pneumonitis. Two patients achieved prompt and complete reestablishment of the chronic phase of CGL. One died on day 72 with a fungal pheumonitis and one developed blastic transformation within 4 months. These preliminary results indicate that this approach to the treatment of blastic transformation of CGL is feasible but difficult. Improvements in results may be achieved by more frequent storage of marrow and pheripheral blood stem cells and lymphocytes and further advances in pretransplant therapy.}
journal = {Exp. Hematol.; (Denmark)}
volume = {6}
place = {Denmark}
year = {1978}
month = {Jan}
}