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Magnetic resonance imaging in multiple system atrophy

Journal Article:

Abstract

We studied 18 patients with multiple system atrophy (MSA) by high field strength MRI: 6 striatonigral degeneration (SND), 4 Shy-Drager syndrome (SDS), and 8 olivo-ponto-cerebellar atrophy (OPCA). We also studied 30 Parkinson's disease (PD) and 10 age-matched controls. The diagnosis of SND, SDS, and OPCA were based on criteria after Hirayama et al (1985). Bradykinesia, rigidity, and tremor were assessed with the summed scores of the signs used as the extrapyramidal scores. The mean extrapyramidal scores were not significantly different in patients with SND, SDS, OPCA, and PD. MRI studies were performed on 1.5 tesla MRI unit, using a T[sub 2]-weighted spin echo pulse sequence (TR2500 ms/TE40 ms). The width of the pars compacta signal in all subjects was measured by the method of Duguid et al (1986). Intensity profiles were made on a straight line perpendicular to the pars compacta through the center of the red nucleus on an image of the midbrain. We measured the width of the valley at half-height between the peaks of an index of the width of the pars compacta signal. The mean widths of the pars compacta signal were: 2.8[+-]0.4 mm (SND), 2.8[+-]0.7 mm (SDS), 3.6[+-]0.6 mm (OPCA), 2.7[+-]0.3 mm (PD), and 4.3[+-]0.6  More>>
Authors:
Aotsuka, Akiyo; Shinotoh, Hitoshi; Hirayama, Keizo; [1]  Ikehira, Hiroo; Hashimoto, Takahiro
  1. Chiba Univ. (Japan). School of Medicine
Publication Date:
Aug 01, 1992
Product Type:
Journal Article
Reference Number:
JPN-93-002356; EDB-93-041439
Resource Relation:
Journal Name: Rinsho Shinkeigaku (Clinical Neurology); (Japan); Journal Volume: 32:8
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBELLUM; NMR IMAGING; ATROPHY; NERVOUS SYSTEM DISEASES; SIGNALS; SPIN-SPIN RELAXATION; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; NERVOUS SYSTEM; ORGANS; PATHOLOGICAL CHANGES; RELAXATION; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
6737451
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0009-918X; CODEN: RISHBH
Submitting Site:
JPN
Size:
Pages: 815-821
Announcement Date:

Journal Article:

Citation Formats

Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Hashimoto, Takahiro. Magnetic resonance imaging in multiple system atrophy. Japan: N. p., 1992. Web.
Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, & Hashimoto, Takahiro. Magnetic resonance imaging in multiple system atrophy. Japan.
Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Hashimoto, Takahiro. 1992. "Magnetic resonance imaging in multiple system atrophy." Japan.
@misc{etde_6737451,
title = {Magnetic resonance imaging in multiple system atrophy}
author = {Aotsuka, Akiyo, Shinotoh, Hitoshi, Hirayama, Keizo, Ikehira, Hiroo, and Hashimoto, Takahiro}
abstractNote = {We studied 18 patients with multiple system atrophy (MSA) by high field strength MRI: 6 striatonigral degeneration (SND), 4 Shy-Drager syndrome (SDS), and 8 olivo-ponto-cerebellar atrophy (OPCA). We also studied 30 Parkinson's disease (PD) and 10 age-matched controls. The diagnosis of SND, SDS, and OPCA were based on criteria after Hirayama et al (1985). Bradykinesia, rigidity, and tremor were assessed with the summed scores of the signs used as the extrapyramidal scores. The mean extrapyramidal scores were not significantly different in patients with SND, SDS, OPCA, and PD. MRI studies were performed on 1.5 tesla MRI unit, using a T[sub 2]-weighted spin echo pulse sequence (TR2500 ms/TE40 ms). The width of the pars compacta signal in all subjects was measured by the method of Duguid et al (1986). Intensity profiles were made on a straight line perpendicular to the pars compacta through the center of the red nucleus on an image of the midbrain. We measured the width of the valley at half-height between the peaks of an index of the width of the pars compacta signal. The mean widths of the pars compacta signal were: 2.8[+-]0.4 mm (SND), 2.8[+-]0.7 mm (SDS), 3.6[+-]0.6 mm (OPCA), 2.7[+-]0.3 mm (PD), and 4.3[+-]0.6 mm (control). The mean widths of the pars compacta signal in PD, SND, and SDS were significantly narrower than that in the control group (p<0.05), while the OPCA group was not significantly narrower. The results may indicate that the time course of nigral involvement is milder in OPCA than in SND and SDS. The extrapyramidal signs in OPCA may be attributed mainly to the degeneration of the putamen rather than to that of the substantia nigra. Abnormal hypointensity in the posterolateral putamen was found in only one SND patient and in two OPCA patients, even though this finding has been frequently observed in MSA. Since no PD patients exhibited this finding, it may of some value in differentiating MSA from PD. (author).}
journal = {Rinsho Shinkeigaku (Clinical Neurology); (Japan)}
volume = {32:8}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Aug}
}