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Application of cytotoxicity test for toxic micropollutants. Saibo dokusei shiken ni yoru yugai kagaku busshitsu osen no hyoka

Abstract

Considerations were given from a viewpoint of assessing toxicity to human bodies on methods of assessing water pollutants and organisms, and applicability of cytotoxity test using cultured cells to water quality assessment. Biological assessment systems used for water environment may use tests using multicellular organisms, cells, or organelles in cells. The organism assessment method is intended mainly for assessing ecological effects, and a suitable method must be selected upon extrapolating it to human bodies. A toxicity parameter used most frequently in a cytotoxity test is the cell revival rate, and life and death are determined from liberation of enzymes in cells, or with color rejection tests and incorporation tests. There are a number of test specimens of raw tap water and its chlorine treatment condensate that show no mutagenicity but cytotoxity. Efficiencies of removal by means of mild chlorine treatment, fast filtration, and activated carbon adsorption vary greatly with cytotoxity and mutagenicity. Introducing the cytotoxity test is expected of further contributing to improving safety in water quality. 24 refs., 1 fig., 7 tabs.
Authors:
Utsumi, H; Hamada, A; [1]  Ono, Y [2] 
  1. Showa University, Tokyo (Japan). School of Pharmaceutical Science
  2. National Institute of Hygienic Sciences, Tokyo (Japan)
Publication Date:
Oct 01, 1992
Product Type:
Journal Article
Reference Number:
NEDO-92-914009; EDB-93-055199
Resource Relation:
Journal Name: Mizu Kankyo Gakkaishi (Journal of Japan Society on Water Environment); (Japan); Journal Volume: 15:10
Subject:
54 ENVIRONMENTAL SCIENCES; 29 ENERGY PLANNING, POLICY AND ECONOMY; BIOASSAY; CYTOLOGICAL TECHNIQUES; ECOSYSTEMS; MAN; SAFETY STANDARDS; TOXICITY; DRINKING WATER; CONTAMINATION; HAZARDOUS MATERIALS; WATER POLLUTION; BIOLOGICAL EFFECTS; ENZYMES; LETHAL DOSES; ACTIVATED CARBON; ADSORPTION; FILTRATION; MUTAGENS; REMOVAL; WATER RESERVOIRS; WATER TREATMENT; WATER UTILITIES; ADSORBENTS; ANIMALS; CARBON; DOSES; ELEMENTS; HYDROGEN COMPOUNDS; MAMMALS; MATERIALS; NONMETALS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; POLLUTION; PRIMATES; PROTEINS; PUBLIC UTILITIES; SEPARATION PROCESSES; SORPTION; STANDARDS; SURFACE WATERS; VERTEBRATES; WATER; 540320* - Environment, Aquatic- Chemicals Monitoring & Transport- (1990-); 290300 - Energy Planning & Policy- Environment, Health, & Safety
OSTI ID:
6708296
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0916-8958; CODEN: MKGAEY
Submitting Site:
NEDO
Size:
Pages: 23-29
Announcement Date:
May 01, 1993

Citation Formats

Utsumi, H, Hamada, A, and Ono, Y. Application of cytotoxicity test for toxic micropollutants. Saibo dokusei shiken ni yoru yugai kagaku busshitsu osen no hyoka. Japan: N. p., 1992. Web.
Utsumi, H, Hamada, A, & Ono, Y. Application of cytotoxicity test for toxic micropollutants. Saibo dokusei shiken ni yoru yugai kagaku busshitsu osen no hyoka. Japan.
Utsumi, H, Hamada, A, and Ono, Y. 1992. "Application of cytotoxicity test for toxic micropollutants. Saibo dokusei shiken ni yoru yugai kagaku busshitsu osen no hyoka." Japan.
@misc{etde_6708296,
title = {Application of cytotoxicity test for toxic micropollutants. Saibo dokusei shiken ni yoru yugai kagaku busshitsu osen no hyoka}
author = {Utsumi, H, Hamada, A, and Ono, Y}
abstractNote = {Considerations were given from a viewpoint of assessing toxicity to human bodies on methods of assessing water pollutants and organisms, and applicability of cytotoxity test using cultured cells to water quality assessment. Biological assessment systems used for water environment may use tests using multicellular organisms, cells, or organelles in cells. The organism assessment method is intended mainly for assessing ecological effects, and a suitable method must be selected upon extrapolating it to human bodies. A toxicity parameter used most frequently in a cytotoxity test is the cell revival rate, and life and death are determined from liberation of enzymes in cells, or with color rejection tests and incorporation tests. There are a number of test specimens of raw tap water and its chlorine treatment condensate that show no mutagenicity but cytotoxity. Efficiencies of removal by means of mild chlorine treatment, fast filtration, and activated carbon adsorption vary greatly with cytotoxity and mutagenicity. Introducing the cytotoxity test is expected of further contributing to improving safety in water quality. 24 refs., 1 fig., 7 tabs.}
journal = []
volume = {15:10}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Oct}
}