Abstract
Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (K/sub D/ = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of (/sup 76/Br)bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in human brain. 20 refs.; 6 figs.; 1 table.
Citation Formats
Maziere, B, Loc'h, C, Stulzaft, O, Ottaviani, M, Comar, D, Maziere, M, and Hantraye, P.
(/sup 76/Br)Bromolisuride: a new tool for quantitative in vivo imaging of D-2 dopamine receptors.
Netherlands: N. p.,
1986.
Web.
Maziere, B, Loc'h, C, Stulzaft, O, Ottaviani, M, Comar, D, Maziere, M, & Hantraye, P.
(/sup 76/Br)Bromolisuride: a new tool for quantitative in vivo imaging of D-2 dopamine receptors.
Netherlands.
Maziere, B, Loc'h, C, Stulzaft, O, Ottaviani, M, Comar, D, Maziere, M, and Hantraye, P.
1986.
"(/sup 76/Br)Bromolisuride: a new tool for quantitative in vivo imaging of D-2 dopamine receptors."
Netherlands.
@misc{etde_6707790,
title = {(/sup 76/Br)Bromolisuride: a new tool for quantitative in vivo imaging of D-2 dopamine receptors}
author = {Maziere, B, Loc'h, C, Stulzaft, O, Ottaviani, M, Comar, D, Maziere, M, and Hantraye, P}
abstractNote = {Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (K/sub D/ = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of (/sup 76/Br)bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in human brain. 20 refs.; 6 figs.; 1 table.}
journal = []
volume = {127:3}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {Aug}
}
title = {(/sup 76/Br)Bromolisuride: a new tool for quantitative in vivo imaging of D-2 dopamine receptors}
author = {Maziere, B, Loc'h, C, Stulzaft, O, Ottaviani, M, Comar, D, Maziere, M, and Hantraye, P}
abstractNote = {Bromolisuride, an ergoline derivative, was labeled with the positron emitter radionuclide, bromine 76. In vitro and in vivo binding and competition studies in rats demonstrated a high affinity (K/sub D/ = 0.3 nM) and a high specificity of this new radioligand for D-2 dopamine receptors. PET kinetic studies in baboons showed an accumulation of (/sup 76/Br)bromolisuride in the striatum which reached a maximum 30 min post-injection and which could be displaced by haloperidol. All these results indicated that this new ligand is certainly suitable for the non-invasive in vivo quantitative imaging of D-2 dopamine receptor sites in human brain. 20 refs.; 6 figs.; 1 table.}
journal = []
volume = {127:3}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {Aug}
}