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Cerebrospinal fluid cells and proteins in patients occupationally exposed to organic solvents

Journal Article:

Abstract

Cerebrospinal fluid (CSF) cells and proteins were determined for 33 patients exposed to industrial organic solvents. A lymphoid reaction, i.e., a pathologically elevated number or percentage of enlarged lymphoid cells was observed in one-third of the patients, more often in patients with chronic intoxication (40%) than in those currently exposed to organic solvents (32%). An almost significant decrease of small lymphocytes in the CSF was observed among patients who had a past history of chronic solvent intoxication but no recent exposure. No cytological evidence of tissue destruction was found. Signs of slight blood--CSF barrier damage occurred in 5 (23%) of the currently exposed patients, but intrathecal IgG synthesis was not observed. Increased cellular activity in the CSF was also accentuated in principal component analysis. The results suggest slight nonspecific immunoactivation in the central nervous system of subjects exposed to organic solvents.
Publication Date:
Jun 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-83-019233
Resource Relation:
Journal Name: J. Neurol. Sci.; (Netherlands); Journal Volume: 54:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ORGANIC SOLVENTS; BIOLOGICAL EFFECTS; TOXICITY; BIOSYNTHESIS; CEREBROSPINAL FLUID; IMMUNOGLOBULINS; LYMPHOCYTES; OCCUPATIONAL DISEASES; PATIENTS; PERSONNEL; SENSITIVITY; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; GLOBULINS; LEUKOCYTES; MATERIALS; ORGANIC COMPOUNDS; PROTEINS; SOLVENTS; SOMATIC CELLS; SYNTHESIS; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
6706973
Research Organizations:
Neuroscience Group, Department of Occupational Medicine, Institute of Occupational Health, Helsinki, Finland
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JNSCA
Submitting Site:
HEDB
Size:
Pages: 413-425
Announcement Date:
Oct 01, 1982

Journal Article:

Citation Formats

Juntunen, J, Taskinen, E, Luisto, M, Iivanainen, M, and Nurminen, M. Cerebrospinal fluid cells and proteins in patients occupationally exposed to organic solvents. Netherlands: N. p., 1982. Web.
Juntunen, J, Taskinen, E, Luisto, M, Iivanainen, M, & Nurminen, M. Cerebrospinal fluid cells and proteins in patients occupationally exposed to organic solvents. Netherlands.
Juntunen, J, Taskinen, E, Luisto, M, Iivanainen, M, and Nurminen, M. 1982. "Cerebrospinal fluid cells and proteins in patients occupationally exposed to organic solvents." Netherlands.
@misc{etde_6706973,
title = {Cerebrospinal fluid cells and proteins in patients occupationally exposed to organic solvents}
author = {Juntunen, J, Taskinen, E, Luisto, M, Iivanainen, M, and Nurminen, M}
abstractNote = {Cerebrospinal fluid (CSF) cells and proteins were determined for 33 patients exposed to industrial organic solvents. A lymphoid reaction, i.e., a pathologically elevated number or percentage of enlarged lymphoid cells was observed in one-third of the patients, more often in patients with chronic intoxication (40%) than in those currently exposed to organic solvents (32%). An almost significant decrease of small lymphocytes in the CSF was observed among patients who had a past history of chronic solvent intoxication but no recent exposure. No cytological evidence of tissue destruction was found. Signs of slight blood--CSF barrier damage occurred in 5 (23%) of the currently exposed patients, but intrathecal IgG synthesis was not observed. Increased cellular activity in the CSF was also accentuated in principal component analysis. The results suggest slight nonspecific immunoactivation in the central nervous system of subjects exposed to organic solvents.}
journal = {J. Neurol. Sci.; (Netherlands)}
volume = {54:3}
journal type = {AC}
place = {Netherlands}
year = {1982}
month = {Jun}
}