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Clinical prognosis of patients with diagnosed chronic solvent intoxication

Abstract

The clinical symptoms and signs of 80 patients with chronic organic solvent intoxication were evaluated after 3-9 years (mean 5.8 years) of follow-up. Thirty-one of the patients had slight clinical neurological signs at the time of diagnosis while the rest of the patients had only neurophysiological or psychological disturbances. The most common subjective symptoms were headache, tiredness and memory disturbances. Of the clinical signs, disturbances occurred frequently in cerebellar functions, gait and station and fine motorics. In addition, psycho-organic alteration and neurasthenic signs were often found. After the follow-up clinical signs of impairment in the nervous system were present in 42 cases. At the group level, the subjective symptoms decreased during the follow-up but the objective clinical signs increased and worsened. Only the prognosis of disturbances in gait and station correlated with the duration and intensity of exposure. The present results emphasize the great difficulties arising in occupational neurology regarding chronic organic solvent intoxications. No clear-cut clinical picture exists and reliable estimation of prognosis in general cannot be made on the basis of the present knowledge.
Publication Date:
May 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-83-019237
Resource Relation:
Journal Name: Acta Neurol. Scand.; (Denmark); Journal Volume: 65:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; CEREBELLUM; SENSITIVITY; ORGANIC SOLVENTS; BIOLOGICAL EFFECTS; TOXICITY; NEUROLOGY; OCCUPATIONAL DISEASES; PATHOLOGY; PATIENTS; PSYCHOLOGY; SYMPTOMS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; MEDICINE; NERVOUS SYSTEM; ORGANS; SOLVENTS; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 551000 - Physiological Systems; 550900 - Pathology
OSTI ID:
6706962
Research Organizations:
Neuroscience Group, Department of Occupational Medicine, Institute of Occupational Health, Helsinki, Finland
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ANRSA
Submitting Site:
HEDB
Size:
Pages: 488-503
Announcement Date:
Dec 01, 1982

Citation Formats

Juntunen, J, Antti-Poika, M, Tola, S, and Partanen, T. Clinical prognosis of patients with diagnosed chronic solvent intoxication. Denmark: N. p., 1982. Web. doi:10.1111/j.1600-0404.1982.tb03105.x.
Juntunen, J, Antti-Poika, M, Tola, S, & Partanen, T. Clinical prognosis of patients with diagnosed chronic solvent intoxication. Denmark. https://doi.org/10.1111/j.1600-0404.1982.tb03105.x
Juntunen, J, Antti-Poika, M, Tola, S, and Partanen, T. 1982. "Clinical prognosis of patients with diagnosed chronic solvent intoxication." Denmark. https://doi.org/10.1111/j.1600-0404.1982.tb03105.x.
@misc{etde_6706962,
title = {Clinical prognosis of patients with diagnosed chronic solvent intoxication}
author = {Juntunen, J, Antti-Poika, M, Tola, S, and Partanen, T}
abstractNote = {The clinical symptoms and signs of 80 patients with chronic organic solvent intoxication were evaluated after 3-9 years (mean 5.8 years) of follow-up. Thirty-one of the patients had slight clinical neurological signs at the time of diagnosis while the rest of the patients had only neurophysiological or psychological disturbances. The most common subjective symptoms were headache, tiredness and memory disturbances. Of the clinical signs, disturbances occurred frequently in cerebellar functions, gait and station and fine motorics. In addition, psycho-organic alteration and neurasthenic signs were often found. After the follow-up clinical signs of impairment in the nervous system were present in 42 cases. At the group level, the subjective symptoms decreased during the follow-up but the objective clinical signs increased and worsened. Only the prognosis of disturbances in gait and station correlated with the duration and intensity of exposure. The present results emphasize the great difficulties arising in occupational neurology regarding chronic organic solvent intoxications. No clear-cut clinical picture exists and reliable estimation of prognosis in general cannot be made on the basis of the present knowledge.}
doi = {10.1111/j.1600-0404.1982.tb03105.x}
journal = []
volume = {65:5}
journal type = {AC}
place = {Denmark}
year = {1982}
month = {May}
}