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Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents

Journal Article:

Abstract

The biological fate of two new radioiodinated 3-methyl-branched fatty acids has been evaluated in rat hearts following intravenous administration. Methyl-branching was introduced in (15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) and 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP) to inhibit ..beta..-oxidation. The goals of these studies were to correlate the effects of methyl-branching on the incorporation of these agents into the various fatty acid pools and subcellular distribution profiles, and to relate these data to the myocardial retention properties. The properties of BMIPP and DMIPP were compared with the 15-(p-iodophenyl)pentadecanoic acid straight-chain analogue (IPP). Differences in the heart retention of the analogues after intravenous administration in rats correlated with differences observed in subcellular distribution patterns. The dimethyl DMIPP analogue showed the longest retention and the highest association with the mitochondrial and microsomal fractions (34%, 38%) 30 min after injection. These data are in contrast to the rapid clearance of the straight-chain IPP analogue which showed much lower relative association with the mitochondria and microsomes (18%, 15%). The distribution patterns of each analogue in the various lipid pools appeared consistent with the expected capacity of the analogues to be metabolized by ..beta..-oxidation. In contrast to the rapid oxidation of the straight-chain IPP analogue, the 3-monomethyl BMIPP analogue appeared to  More>>
Publication Date:
Jan 01, 1987
Product Type:
Journal Article
Reference Number:
DEN-87-003075; EDB-87-066701
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 12:10
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; MONOCARBOXYLIC ACIDS; METHYLATION; SUBCELLULAR DISTRIBUTION; MYOCARDIUM; METABOLISM; SCINTISCANNING; CELL CONSTITUENTS; CLEARANCE; COMPARATIVE EVALUATIONS; IMAGES; LIPIDS; RADIOPHARMACEUTICALS; RATS; RETENTION; TISSUE DISTRIBUTION; TRACER TECHNIQUES; ANIMALS; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR SYSTEM; CHEMICAL REACTIONS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; DRUGS; HEART; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MUSCLES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPE SCANNING; RODENTS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550501 - Metabolism- Tracer Techniques
OSTI ID:
6702321
Research Organizations:
Oak Ridge National Lab., TN, USA. Health and Safety Research Div.
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
DEN
Size:
Pages: 486-491
Announcement Date:

Journal Article:

Citation Formats

Ambrose, K R, Owen, B A, Goodman, M M, and Knapp, Jr, F F. Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents. Germany: N. p., 1987. Web.
Ambrose, K R, Owen, B A, Goodman, M M, & Knapp, Jr, F F. Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents. Germany.
Ambrose, K R, Owen, B A, Goodman, M M, and Knapp, Jr, F F. 1987. "Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents." Germany.
@misc{etde_6702321,
title = {Evaluation of the metabolism in rat hearts of two new radioiodinated 3-methyl-branched fatty acid myocardial imaging agents}
author = {Ambrose, K R, Owen, B A, Goodman, M M, and Knapp, Jr, F F}
abstractNote = {The biological fate of two new radioiodinated 3-methyl-branched fatty acids has been evaluated in rat hearts following intravenous administration. Methyl-branching was introduced in (15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) and 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP) to inhibit ..beta..-oxidation. The goals of these studies were to correlate the effects of methyl-branching on the incorporation of these agents into the various fatty acid pools and subcellular distribution profiles, and to relate these data to the myocardial retention properties. The properties of BMIPP and DMIPP were compared with the 15-(p-iodophenyl)pentadecanoic acid straight-chain analogue (IPP). Differences in the heart retention of the analogues after intravenous administration in rats correlated with differences observed in subcellular distribution patterns. The dimethyl DMIPP analogue showed the longest retention and the highest association with the mitochondrial and microsomal fractions (34%, 38%) 30 min after injection. These data are in contrast to the rapid clearance of the straight-chain IPP analogue which showed much lower relative association with the mitochondria and microsomes (18%, 15%). The distribution patterns of each analogue in the various lipid pools appeared consistent with the expected capacity of the analogues to be metabolized by ..beta..-oxidation. In contrast to the rapid oxidation of the straight-chain IPP analogue, the 3-monomethyl BMIPP analogue appeared to undergo slower oxidation and clearance, whereas the dimethyl-branched DMIPP analogue was apparatently not catabolized by the myocardium. All three analogues showed some incorporation into triglycerides. The metabolism patterns of the branched analogues reported here may provide useful information in the description of the mechanisms by which BMIPP and DMIPP are retained in rat myocardium.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {12:10}
journal type = {AC}
place = {Germany}
year = {1987}
month = {Jan}
}