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Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development

Abstract

Wistar rat pups were administered either a high dose of lead acetate (400 {mu}g lead-g body weight/day) or a low dose (100 {mu}g lead/g body weight/day) by gastric intubation, from 2 days through 60 days of age. The rats on both these doses exhibited statistically significant decreases in body and brain weights throughout the lead treatment period. A group of rats on high dose was also rehabilitated by discontinuing the lead from 60 days of age. In these rats, at 160 days of age, the body weight but not the brain weight recovered to normal levels. During the lead intake, the rats on high dose revealed significant elevations in the levels of noradrenaline (NA) in the hippocampus (HI), cerebellum (CE), hypothalamus (HY), brainstem (BS), and accumbens-striatum (SA). The elevated levels in all the above regions except in the HY persisted even after rehabilitation. The dopamine (DA) levels changed significantly in opposite directions in HY (elevation) and BS (reduction) during the lead treatment, and the HY recovered after rehabilitation. Under lead, the serotonin (5HT) levels were elevated significantly in the HI, BS and MC (motor cortex), while after rehabilitation the abnormality persisted only in the MC. Low dose lead treatment was  More>>
Authors:
Shailesh Kumar, M V; Desiraju, T [1] 
  1. National Inst. of Mental Health and Neuro Sciences, Bangalore (India). Dept. of Neurophysiology
Publication Date:
Jun 01, 1990
Product Type:
Journal Article
Reference Number:
DE-90-008210; EDB-90-126711
Resource Relation:
Journal Name: Archives of Toxicology; (Germany, F.R.); Journal Volume: 64:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; LEAD; TOXICITY; AMINES; AMINOBUTYRIC ACID; BIOCHEMISTRY; BODY; CHRONIC EXPOSURE; NEONATES; ORAL ADMINISTRATION; WEIGHT; AMINO ACIDS; AUTONOMIC NERVOUS SYSTEM AGENTS; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHEMISTRY; DRUGS; ELEMENTS; METALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; 560300* - Chemicals Metabolism & Toxicology
OSTI ID:
6693624
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0340-5761; CODEN: ARTOD
Submitting Site:
DE
Size:
Pages: 305-314
Announcement Date:
Sep 01, 1990

Citation Formats

Shailesh Kumar, M V, and Desiraju, T. Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development. Germany: N. p., 1990. Web. doi:10.1007/BF01972991.
Shailesh Kumar, M V, & Desiraju, T. Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development. Germany. https://doi.org/10.1007/BF01972991
Shailesh Kumar, M V, and Desiraju, T. 1990. "Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development." Germany. https://doi.org/10.1007/BF01972991.
@misc{etde_6693624,
title = {Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development}
author = {Shailesh Kumar, M V, and Desiraju, T}
abstractNote = {Wistar rat pups were administered either a high dose of lead acetate (400 {mu}g lead-g body weight/day) or a low dose (100 {mu}g lead/g body weight/day) by gastric intubation, from 2 days through 60 days of age. The rats on both these doses exhibited statistically significant decreases in body and brain weights throughout the lead treatment period. A group of rats on high dose was also rehabilitated by discontinuing the lead from 60 days of age. In these rats, at 160 days of age, the body weight but not the brain weight recovered to normal levels. During the lead intake, the rats on high dose revealed significant elevations in the levels of noradrenaline (NA) in the hippocampus (HI), cerebellum (CE), hypothalamus (HY), brainstem (BS), and accumbens-striatum (SA). The elevated levels in all the above regions except in the HY persisted even after rehabilitation. The dopamine (DA) levels changed significantly in opposite directions in HY (elevation) and BS (reduction) during the lead treatment, and the HY recovered after rehabilitation. Under lead, the serotonin (5HT) levels were elevated significantly in the HI, BS and MC (motor cortex), while after rehabilitation the abnormality persisted only in the MC. Low dose lead treatment was also effective on the same areas of brain. In the low dose group, estimation of the levels of GABA and glutamate were also done, and a significant decrease of GABA in CE and glutamate in MC was observed. The differences observed in the neurotoxic effects (none or significant) of lead in the different regions for each of the transmitters (NA, DA, 5HT) supports the interesting conclusion that the vulnerability of the axon terminals of any given type is dependent on some regional factors, although the projections of the different regions originate from an apparently similar category of neurons in the brain stem. (orig.).}
doi = {10.1007/BF01972991}
journal = []
volume = {64:4}
journal type = {AC}
place = {Germany}
year = {1990}
month = {Jun}
}