## Abstract

There are currently a number of radiobiological models to account for the effects of dose fractionation and time. Normalized total dose (NTD) is not another new model but is a previously reported, clinically useful form in which to represent the biological effect, determined by any specific radiobiological dose-fractionation model, of a course of radiation using a single set of standardized, easily understood terminology. The generalized form of NTD reviewed in this paper describes the effect of a course of radiotherapy administered with nonstandard fractionation as the total dose of radiation in Gy that could be administered with a given reference fractionation such as 2 Gy per fraction, 5 fractions per week that would produce an equivalent biological effect (probability of complications or tumor control) as predicted by a given dose-fractionation formula. The use of normalized total dose with several different exponential and linear-quadratic dose-fraction formulas is presented. (author). 51 refs.; 1 fig.; 1 tab.

Flickinger, J C;
Kalend, A

^{[1] }## Citation Formats

Flickinger, J C, and Kalend, A.
Use of normalized total dose to represent the biological effect of fractionated radiotherapy.
Netherlands: N. p.,
1990.
Web.
doi:10.1016/0167-8140(90)90007-J.

Flickinger, J C, & Kalend, A.
Use of normalized total dose to represent the biological effect of fractionated radiotherapy.
Netherlands.
doi:10.1016/0167-8140(90)90007-J.

Flickinger, J C, and Kalend, A.
1990.
"Use of normalized total dose to represent the biological effect of fractionated radiotherapy."
Netherlands.
doi:10.1016/0167-8140(90)90007-J.
https://www.osti.gov/servlets/purl/10.1016/0167-8140(90)90007-J.

@misc{etde_6691114,

title = {Use of normalized total dose to represent the biological effect of fractionated radiotherapy}

author = {Flickinger, J C, and Kalend, A}

abstractNote = {There are currently a number of radiobiological models to account for the effects of dose fractionation and time. Normalized total dose (NTD) is not another new model but is a previously reported, clinically useful form in which to represent the biological effect, determined by any specific radiobiological dose-fractionation model, of a course of radiation using a single set of standardized, easily understood terminology. The generalized form of NTD reviewed in this paper describes the effect of a course of radiotherapy administered with nonstandard fractionation as the total dose of radiation in Gy that could be administered with a given reference fractionation such as 2 Gy per fraction, 5 fractions per week that would produce an equivalent biological effect (probability of complications or tumor control) as predicted by a given dose-fractionation formula. The use of normalized total dose with several different exponential and linear-quadratic dose-fraction formulas is presented. (author). 51 refs.; 1 fig.; 1 tab.}

doi = {10.1016/0167-8140(90)90007-J}

journal = {Radiotherapy and Oncology; (Netherlands)}

volume = {17:3}

journal type = {AC}

place = {Netherlands}

year = {1990}

month = {Mar}

}

title = {Use of normalized total dose to represent the biological effect of fractionated radiotherapy}

author = {Flickinger, J C, and Kalend, A}

abstractNote = {There are currently a number of radiobiological models to account for the effects of dose fractionation and time. Normalized total dose (NTD) is not another new model but is a previously reported, clinically useful form in which to represent the biological effect, determined by any specific radiobiological dose-fractionation model, of a course of radiation using a single set of standardized, easily understood terminology. The generalized form of NTD reviewed in this paper describes the effect of a course of radiotherapy administered with nonstandard fractionation as the total dose of radiation in Gy that could be administered with a given reference fractionation such as 2 Gy per fraction, 5 fractions per week that would produce an equivalent biological effect (probability of complications or tumor control) as predicted by a given dose-fractionation formula. The use of normalized total dose with several different exponential and linear-quadratic dose-fraction formulas is presented. (author). 51 refs.; 1 fig.; 1 tab.}

doi = {10.1016/0167-8140(90)90007-J}

journal = {Radiotherapy and Oncology; (Netherlands)}

volume = {17:3}

journal type = {AC}

place = {Netherlands}

year = {1990}

month = {Mar}

}