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Use of normalized total dose to represent the biological effect of fractionated radiotherapy

Abstract

There are currently a number of radiobiological models to account for the effects of dose fractionation and time. Normalized total dose (NTD) is not another new model but is a previously reported, clinically useful form in which to represent the biological effect, determined by any specific radiobiological dose-fractionation model, of a course of radiation using a single set of standardized, easily understood terminology. The generalized form of NTD reviewed in this paper describes the effect of a course of radiotherapy administered with nonstandard fractionation as the total dose of radiation in Gy that could be administered with a given reference fractionation such as 2 Gy per fraction, 5 fractions per week that would produce an equivalent biological effect (probability of complications or tumor control) as predicted by a given dose-fractionation formula. The use of normalized total dose with several different exponential and linear-quadratic dose-fraction formulas is presented. (author). 51 refs.; 1 fig.; 1 tab.
Authors:
Flickinger, J C; Kalend, A [1] 
  1. Pittsburgh University School of Medicine (USA). Department of Radiation Oncology Pittsburg Cancer Institute (USA)
Publication Date:
Mar 01, 1990
Product Type:
Journal Article
Reference Number:
AIX-21-071234; EDB-90-136653
Resource Relation:
Journal Name: Radiotherapy and Oncology; (Netherlands); Journal Volume: 17:3
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FRACTIONATED IRRADIATION; RADIOTHERAPY; RADIATION DOSES; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL MODELS; BIOLOGICAL EFFECTS; DOSES; IRRADIATION; MEDICINE; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIOLOGY; THERAPY; 655003* - Medical Physics- Dosimetry; 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture
OSTI ID:
6691114
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0167-8140; CODEN: RAOND
Submitting Site:
NLN
Size:
Pages: 339-347
Announcement Date:

Citation Formats

Flickinger, J C, and Kalend, A. Use of normalized total dose to represent the biological effect of fractionated radiotherapy. Netherlands: N. p., 1990. Web. doi:10.1016/0167-8140(90)90007-J.
Flickinger, J C, & Kalend, A. Use of normalized total dose to represent the biological effect of fractionated radiotherapy. Netherlands. doi:10.1016/0167-8140(90)90007-J.
Flickinger, J C, and Kalend, A. 1990. "Use of normalized total dose to represent the biological effect of fractionated radiotherapy." Netherlands. doi:10.1016/0167-8140(90)90007-J. https://www.osti.gov/servlets/purl/10.1016/0167-8140(90)90007-J.
@misc{etde_6691114,
title = {Use of normalized total dose to represent the biological effect of fractionated radiotherapy}
author = {Flickinger, J C, and Kalend, A}
abstractNote = {There are currently a number of radiobiological models to account for the effects of dose fractionation and time. Normalized total dose (NTD) is not another new model but is a previously reported, clinically useful form in which to represent the biological effect, determined by any specific radiobiological dose-fractionation model, of a course of radiation using a single set of standardized, easily understood terminology. The generalized form of NTD reviewed in this paper describes the effect of a course of radiotherapy administered with nonstandard fractionation as the total dose of radiation in Gy that could be administered with a given reference fractionation such as 2 Gy per fraction, 5 fractions per week that would produce an equivalent biological effect (probability of complications or tumor control) as predicted by a given dose-fractionation formula. The use of normalized total dose with several different exponential and linear-quadratic dose-fraction formulas is presented. (author). 51 refs.; 1 fig.; 1 tab.}
doi = {10.1016/0167-8140(90)90007-J}
journal = {Radiotherapy and Oncology; (Netherlands)}
volume = {17:3}
journal type = {AC}
place = {Netherlands}
year = {1990}
month = {Mar}
}