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Study on the plasma proteins of A-bomb survived patients including those suffered by the remained radioactivities. Report 2. Quantitative observation of the plasma protein fractions by electrophoretic test and to solve the problems for physiological clinical significance of its patterns

Journal Article:

Abstract

The plasma proteins of A-bombed survivors, healthy persons, long term x-ray equipment handling people (for instance the radiologists and x-ray technicians), cancer patients, and tumor irradiated cancer patients were examined by the electrophoretic test. It was found that the electrophoretic patterns of plasma proteins could be divided into normal (N-pattern) and abnormal (..beta.. and ..gamma.. patterns) patterns, when they were classified according to the accents of each fraction. The patterns of the healthy persons and the long term x-ray handling people showed normal (N) pattern, however, it showed 43% abnormal patterns in A-bombed survivors and 48% in cancer patients. Furthermore, the patterns could be changed by radiotherapy to cancer, ie., from N to ..beta.. or vice versa. As a result of the quantitative observation about individual pattern, the accents of ..beta..-globulins in ..beta..-patterns and ..gamma..-globulins in ..gamma..-patterns were found. The globulins increased in the A bomb survivors and the long term x-ray handling people, and this increase was also seen in the cases of cancer patients which showed 85% of them were effected with uclers (self disintegrated) by clinical examinations. A physiological clinical significance of these abnormal patterns (..beta.. and ..gamma..) in the plasma proteins indicates the disorders in its  More>>
Publication Date:
Oct 01, 1963
Product Type:
Journal Article
Reference Number:
EDB-81-035397
Resource Relation:
Journal Name: Hiroshima Igaku; (Japan); Journal Volume: 16
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; A-BOMB SURVIVORS; GLOBULINS-BETA; GLOBULINS-GAMMA; BLOOD PLASMA; ELECTROPHORESIS; RADIOLOGICAL PERSONNEL; COMPARATIVE EVALUATIONS; NEOPLASMS; PATIENTS; PROTEINS; QUALITATIVE CHEMICAL ANALYSIS; RADIOTHERAPY; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; CHEMICAL ANALYSIS; DISEASES; GLOBULINS; MATERIALS; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; PERSONNEL; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man; 450200 - Military Technology, Weaponry, & National Defense- Nuclear Explosions & Explosives
OSTI ID:
6687752
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HIRGA
Submitting Site:
TIC
Size:
Pages: 885-914
Announcement Date:
Mar 01, 1981

Journal Article:

Citation Formats

Makidono, J, Takanashi, S, Yoshimoto, T, Kai, T, Yoshimoto, K, Matsutani, M, and Miura, M. Study on the plasma proteins of A-bomb survived patients including those suffered by the remained radioactivities. Report 2. Quantitative observation of the plasma protein fractions by electrophoretic test and to solve the problems for physiological clinical significance of its patterns. Japan: N. p., 1963. Web.
Makidono, J, Takanashi, S, Yoshimoto, T, Kai, T, Yoshimoto, K, Matsutani, M, & Miura, M. Study on the plasma proteins of A-bomb survived patients including those suffered by the remained radioactivities. Report 2. Quantitative observation of the plasma protein fractions by electrophoretic test and to solve the problems for physiological clinical significance of its patterns. Japan.
Makidono, J, Takanashi, S, Yoshimoto, T, Kai, T, Yoshimoto, K, Matsutani, M, and Miura, M. 1963. "Study on the plasma proteins of A-bomb survived patients including those suffered by the remained radioactivities. Report 2. Quantitative observation of the plasma protein fractions by electrophoretic test and to solve the problems for physiological clinical significance of its patterns." Japan.
@misc{etde_6687752,
title = {Study on the plasma proteins of A-bomb survived patients including those suffered by the remained radioactivities. Report 2. Quantitative observation of the plasma protein fractions by electrophoretic test and to solve the problems for physiological clinical significance of its patterns}
author = {Makidono, J, Takanashi, S, Yoshimoto, T, Kai, T, Yoshimoto, K, Matsutani, M, and Miura, M}
abstractNote = {The plasma proteins of A-bombed survivors, healthy persons, long term x-ray equipment handling people (for instance the radiologists and x-ray technicians), cancer patients, and tumor irradiated cancer patients were examined by the electrophoretic test. It was found that the electrophoretic patterns of plasma proteins could be divided into normal (N-pattern) and abnormal (..beta.. and ..gamma.. patterns) patterns, when they were classified according to the accents of each fraction. The patterns of the healthy persons and the long term x-ray handling people showed normal (N) pattern, however, it showed 43% abnormal patterns in A-bombed survivors and 48% in cancer patients. Furthermore, the patterns could be changed by radiotherapy to cancer, ie., from N to ..beta.. or vice versa. As a result of the quantitative observation about individual pattern, the accents of ..beta..-globulins in ..beta..-patterns and ..gamma..-globulins in ..gamma..-patterns were found. The globulins increased in the A bomb survivors and the long term x-ray handling people, and this increase was also seen in the cases of cancer patients which showed 85% of them were effected with uclers (self disintegrated) by clinical examinations. A physiological clinical significance of these abnormal patterns (..beta.. and ..gamma..) in the plasma proteins indicates the disorders in its body and an important immunological meaning. Abnormal patterns in those who suffered by the remained radioactivities caused by the A-bomb showed 70%, whose average was much higher than those of direct A-bombed survivors. It is pointed out that, in recent days, there is a trend of more and gradual increase in the malignant neoplamsm than the disorders of direct A-bombed survivors.}
journal = {Hiroshima Igaku; (Japan)}
volume = {16}
journal type = {AC}
place = {Japan}
year = {1963}
month = {Oct}
}