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Clinical results of galantase for diarrhea due to gynecological radiotherapy

Journal Article:

Abstract

Galantase, a preparation of lactose-decomposing enzyme, was used for 20 radiotherapeutic patients for prevention and treatment of diarrhea. The results were compared with those of 58 control cases without administration. In the 58 cases, the timing of onset of diarrhea during irradiation was examined, and the mechanism of onset of radioinjury in the digestive tract was discussed. Galantase 6 g/day was administered to 13 of the 20 patients simultaneously with institution of irradiation and to 7 patients simultaneously with the onset of diarrhea during irradiation. As radiotherapy, the patients were given remote cobalt irradiation 5 times a week, each consisting of 200 rad, a total dose of 5,000 rad, in a field of 14 - 16 x 14 - 16 cm by way of 2 ports (anterior and posterior). Diarrhea and soft stool both appeared by irradiation of less than 300 rad, and diarrhea was observed in 84%. Temporal diarrhea occurred in 3 of the 13 patients given galantase simultaneously with irradiation. Diarrhea continued for 6 days in one of the 6 cases in which galantase was administered simultaneously with the onset of diarrhea or watery stool. In the other 5, the stool recovered to be soft or normal 2-3  More>>
Authors:
Tokunaga, A; [1]  Higuchi, A
  1. Niigata Univ. (Japan). School of Medicine
Publication Date:
Oct 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-391725; EDB-78-117799
Resource Relation:
Journal Name: Shinryo To Shinyaku; (Japan); Journal Volume: 14:10
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DIARRHEA; CHEMOTHERAPY; RADIOPROTECTIVE SUBSTANCES; BIOCHEMICAL REACTION KINETICS; CARCINOMAS; DOSE-RESPONSE RELATIONSHIPS; ENTERITIS; GALACTOSIDASE; RADIATION DOSES; RADIOTHERAPY; SIDE EFFECTS; TIME DEPENDENCE; UROGENITAL SYSTEM DISEASES; DIGESTIVE SYSTEM DISEASES; DISEASES; DOSES; DRUGS; ENZYMES; GLYCOSYL HYDROLASES; HYDROLASES; KINETICS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIOLOGY; REACTION KINETICS; RESPONSE MODIFYING FACTORS; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
6687269
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: SHNSA
Submitting Site:
INIS
Size:
Pages: 2587-2592
Announcement Date:

Journal Article:

Citation Formats

Tokunaga, A, and Higuchi, A. Clinical results of galantase for diarrhea due to gynecological radiotherapy. Japan: N. p., 1977. Web.
Tokunaga, A, & Higuchi, A. Clinical results of galantase for diarrhea due to gynecological radiotherapy. Japan.
Tokunaga, A, and Higuchi, A. 1977. "Clinical results of galantase for diarrhea due to gynecological radiotherapy." Japan.
@misc{etde_6687269,
title = {Clinical results of galantase for diarrhea due to gynecological radiotherapy}
author = {Tokunaga, A, and Higuchi, A}
abstractNote = {Galantase, a preparation of lactose-decomposing enzyme, was used for 20 radiotherapeutic patients for prevention and treatment of diarrhea. The results were compared with those of 58 control cases without administration. In the 58 cases, the timing of onset of diarrhea during irradiation was examined, and the mechanism of onset of radioinjury in the digestive tract was discussed. Galantase 6 g/day was administered to 13 of the 20 patients simultaneously with institution of irradiation and to 7 patients simultaneously with the onset of diarrhea during irradiation. As radiotherapy, the patients were given remote cobalt irradiation 5 times a week, each consisting of 200 rad, a total dose of 5,000 rad, in a field of 14 - 16 x 14 - 16 cm by way of 2 ports (anterior and posterior). Diarrhea and soft stool both appeared by irradiation of less than 300 rad, and diarrhea was observed in 84%. Temporal diarrhea occurred in 3 of the 13 patients given galantase simultaneously with irradiation. Diarrhea continued for 6 days in one of the 6 cases in which galantase was administered simultaneously with the onset of diarrhea or watery stool. In the other 5, the stool recovered to be soft or normal 2-3 days after administration. Diarrhea during irradiaion appeared in 21.4% of the cases given galantase and 42.1% of those without it. The clinical value of galantase was recognized.}
journal = {Shinryo To Shinyaku; (Japan)}
volume = {14:10}
journal type = {AC}
place = {Japan}
year = {1977}
month = {Oct}
}