You need JavaScript to view this

Lymphocyte mediators of delayed hypersensitivity; the early phase cells

Journal Article:

Abstract

Inbred rats were immunized with living Bacillus Calmette-Guerin (BCG) and lymphocytes which mediate tuberculin DTH and anti-tuberculosis immunity were found 10 days later in the draining lymph nodes, thoracic duct, blood, spleen, and acute peritoneal exudates. The lymphocytes that mediated DTH incorporated /sup 3/HT in vitro, were large in size, sensitive to vinblastine but relatively resistant to irradiation, and had a short effective lifespan in syngeneic recipients. These properties characterize the cells as short-lived, nonrecirculating immunoblasts. In some experimental situations it was possible to dissociate the expression of DTH and immunity following the transfer of sensitized lymphocytes.
Authors:
Lefford, M J; McGregor, D D [1] 
  1. Trudeau Inst., Saranac Lake, N.Y. (USA)
Publication Date:
Apr 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-398194; EDB-78-125546
Resource Relation:
Journal Name: Immunology; (United Kingdom); Journal Volume: 34:4
Subject:
59 BASIC BIOLOGICAL SCIENCES; IMMUNITY; LYMPHOCYTES; IMMUNE REACTIONS; RATS; BIOLOGICAL LOCALIZATION; BLOOD; COMPARATIVE EVALUATIONS; CYTOLOGY; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; LABELLING; LYMPH NODES; LYMPH VESSELS; RADIOSENSITIVITY; SENSITIVITY; SPLEEN; THYMIDINE; TIME DEPENDENCE; TRITIUM COMPOUNDS; TUBERCULOSIS; ANIMAL CELLS; ANIMALS; AZINES; BIOLOGICAL MATERIALS; BIOLOGY; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; INFECTIOUS DISEASES; IONIZING RADIATIONS; LABELLED COMPOUNDS; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIATIONS; RIBOSIDES; RODENTS; SOMATIC CELLS; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques
OSTI ID:
6686221
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IMMUA
Submitting Site:
INIS
Size:
Pages: 581-590
Announcement Date:
Sep 01, 1978

Journal Article:

Citation Formats

Lefford, M J, and McGregor, D D. Lymphocyte mediators of delayed hypersensitivity; the early phase cells. United Kingdom: N. p., 1978. Web.
Lefford, M J, & McGregor, D D. Lymphocyte mediators of delayed hypersensitivity; the early phase cells. United Kingdom.
Lefford, M J, and McGregor, D D. 1978. "Lymphocyte mediators of delayed hypersensitivity; the early phase cells." United Kingdom.
@misc{etde_6686221,
title = {Lymphocyte mediators of delayed hypersensitivity; the early phase cells}
author = {Lefford, M J, and McGregor, D D}
abstractNote = {Inbred rats were immunized with living Bacillus Calmette-Guerin (BCG) and lymphocytes which mediate tuberculin DTH and anti-tuberculosis immunity were found 10 days later in the draining lymph nodes, thoracic duct, blood, spleen, and acute peritoneal exudates. The lymphocytes that mediated DTH incorporated /sup 3/HT in vitro, were large in size, sensitive to vinblastine but relatively resistant to irradiation, and had a short effective lifespan in syngeneic recipients. These properties characterize the cells as short-lived, nonrecirculating immunoblasts. In some experimental situations it was possible to dissociate the expression of DTH and immunity following the transfer of sensitized lymphocytes.}
journal = {Immunology; (United Kingdom)}
volume = {34:4}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Apr}
}