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Clinical investigations on the urinary 17-ketogenic steroids. Part IV. Studies on the changes of urinary 17-ketogenic steroids. Excretion by age during adolescence of the children exposed to the atomic bomb in utero

Journal Article:

Abstract

A biochemical study was carried out during a three-year period from 1958 as a joint investigation of Kyoto University and the Atomic Bomb Casualty Commission (ABCC) under a research project to study adolescents who were exposed in utero. Determination of urinary 17-ketogenic steroids (17-KGS) was performed in 275 adolescents drawn from a group of 874 children who were either exposed to the atomic bomb in utero in Nagasaki or who entered the city after the bombing (nonexposed controls). The measurements were done in the same subjects between the age of 13 and 15 at three-month intervals. In the unexposed control group the 17-KGS excretion showed a rapid increase around the age of 14 in males and a slight increase around the same age in females. The mean values in males seemed to become higher than in females around the age of 14. Changes of 17-KGS excretion showed no statistically significant difference between the groups proximally exposed (under 2000 m from the hypocenter) or distally exposed (between 3000 and 5000 m) and the unexposed control children of both sexes. However, the mean values of 17-KGS excretion of every group tended to decrease in the order of unexposed, distally exposed, and proximally  More>>
Authors:
Publication Date:
Jan 01, 1963
Product Type:
Journal Article
Reference Number:
EDB-81-035398
Resource Relation:
Journal Name: Naika Hokan; (Japan); Journal Volume: 10
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; A-BOMB SURVIVORS; URINARY KETOSTEROIDS; ADOLESCENTS; PROGENY; AGE DEPENDENCE; DOSE-RESPONSE RELATIONSHIPS; EXCRETION; NAGASAKI; PRENATAL IRRADIATION; SEX DEPENDENCE; AGE GROUPS; ANIMALS; ASIA; CLEARANCE; IRRADIATION; JAPAN; MAMMALS; MAN; PRENATAL EXPOSURE; PRIMATES; VERTEBRATES; 560151* - Radiation Effects on Animals- Man; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man; 550200 - Biochemistry; 450200 - Military Technology, Weaponry, & National Defense- Nuclear Explosions & Explosives
OSTI ID:
6681251
Research Organizations:
Kyoto Univ., Japan
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NAHOA
Submitting Site:
TIC
Size:
Pages: 235-243
Announcement Date:
Mar 01, 1981

Journal Article:

Citation Formats

Arai, Y. Clinical investigations on the urinary 17-ketogenic steroids. Part IV. Studies on the changes of urinary 17-ketogenic steroids. Excretion by age during adolescence of the children exposed to the atomic bomb in utero. Japan: N. p., 1963. Web.
Arai, Y. Clinical investigations on the urinary 17-ketogenic steroids. Part IV. Studies on the changes of urinary 17-ketogenic steroids. Excretion by age during adolescence of the children exposed to the atomic bomb in utero. Japan.
Arai, Y. 1963. "Clinical investigations on the urinary 17-ketogenic steroids. Part IV. Studies on the changes of urinary 17-ketogenic steroids. Excretion by age during adolescence of the children exposed to the atomic bomb in utero." Japan.
@misc{etde_6681251,
title = {Clinical investigations on the urinary 17-ketogenic steroids. Part IV. Studies on the changes of urinary 17-ketogenic steroids. Excretion by age during adolescence of the children exposed to the atomic bomb in utero}
author = {Arai, Y}
abstractNote = {A biochemical study was carried out during a three-year period from 1958 as a joint investigation of Kyoto University and the Atomic Bomb Casualty Commission (ABCC) under a research project to study adolescents who were exposed in utero. Determination of urinary 17-ketogenic steroids (17-KGS) was performed in 275 adolescents drawn from a group of 874 children who were either exposed to the atomic bomb in utero in Nagasaki or who entered the city after the bombing (nonexposed controls). The measurements were done in the same subjects between the age of 13 and 15 at three-month intervals. In the unexposed control group the 17-KGS excretion showed a rapid increase around the age of 14 in males and a slight increase around the same age in females. The mean values in males seemed to become higher than in females around the age of 14. Changes of 17-KGS excretion showed no statistically significant difference between the groups proximally exposed (under 2000 m from the hypocenter) or distally exposed (between 3000 and 5000 m) and the unexposed control children of both sexes. However, the mean values of 17-KGS excretion of every group tended to decrease in the order of unexposed, distally exposed, and proximally exposed groups in males after the age of 14.5 and in females at the age of 15. Changes of 17-KGS excretion showed no statistically significant difference between the exposed and unexposed groups in terms of 1 to 3 month, 4 to 6 month, and 7 to 10 month of gestation at the time of bombing. From these results it appears that there was no effect of the atomic bomb radiation in the adolescents exposed in utero with regard to their adrenocortical function.}
journal = {Naika Hokan; (Japan)}
volume = {10}
journal type = {AC}
place = {Japan}
year = {1963}
month = {Jan}
}