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Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast

Journal Article:

Abstract

A technique of short-term tests in vitro by means of the incubation of tumor cell suspensions is utilized as a radioactive-biochemical method for pretherapeutic determination of the resistance in human cancers of the breast. Cell suspensions from primary tumors and metastases reveal individually different responses to cytostatics in vitro. It is possible, therewith, to differentiate two tumor collectives related to in vivo resistant or in vivo sensitive tumors. The responses of the primary lesion and the axillary lymphatic metastasis of the same carcinoma may in single cases also differ in vitro, according to clinical experience with the therapy of breast cancer. A distinct relation can be shown between the histological type of a carcinoma and its in vitro capacity of resistance.
Publication Date:
Apr 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-391763; EDB-78-117630
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 154:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MAMMARY GLANDS; CARCINOMAS; TUMOR CELLS; SENSITIVITY; ANTIMITOTIC DRUGS; BIOASSAY; DEOXYURIDINE; HISTOLOGY; IN VITRO; INCUBATION; METASTASES; PRECURSOR; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; URIDINE; ANIMAL CELLS; AZINES; BODY; DISEASES; DRUGS; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; NEOPLASMS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RIBOSIDES; URACILS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6678370
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 277-281
Announcement Date:

Journal Article:

Citation Formats

Kaufmann, M, Kubli, F, Volm, M, Fournier, D V, Reus, W, and Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.). Inst. fuer Experimentelle Pathologie). Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast. Germany: N. p., 1978. Web.
Kaufmann, M, Kubli, F, Volm, M, Fournier, D V, Reus, W, & Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.). Inst. fuer Experimentelle Pathologie). Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast. Germany.
Kaufmann, M, Kubli, F, Volm, M, Fournier, D V, Reus, W, and Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.). Inst. fuer Experimentelle Pathologie). 1978. "Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast." Germany.
@misc{etde_6678370,
title = {Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast}
author = {Kaufmann, M, Kubli, F, Volm, M, Fournier, D V, Reus, W, and Deutsches Krebsforschungszentrum, Heidelberg (Germany, F.R.). Inst. fuer Experimentelle Pathologie)}
abstractNote = {A technique of short-term tests in vitro by means of the incubation of tumor cell suspensions is utilized as a radioactive-biochemical method for pretherapeutic determination of the resistance in human cancers of the breast. Cell suspensions from primary tumors and metastases reveal individually different responses to cytostatics in vitro. It is possible, therewith, to differentiate two tumor collectives related to in vivo resistant or in vivo sensitive tumors. The responses of the primary lesion and the axillary lymphatic metastasis of the same carcinoma may in single cases also differ in vitro, according to clinical experience with the therapy of breast cancer. A distinct relation can be shown between the histological type of a carcinoma and its in vitro capacity of resistance.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {154:4}
journal type = {AC}
place = {Germany}
year = {1978}
month = {Apr}
}