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Neuropsychological evaluation of patients with inoperable non-small cell lung cancer treated with combination chemotherapy or radiotherapy

Journal Article:

Abstract

Neuropsychological tests were used to evaluate possible central nervous system dysfunction in patients treated with chemotherapy. Ninety-five patients with non-small cell lung cancer limited disease were randomized to either radiotherapy (2.8 Gyx15) or combination chemotherapy with cisplatin and etoposide. In order to evaluate cognitive functions three neuropsychological tests were applied: Trail Making, Benton Visual Retention Test and Verbal Learning. Changes in the patients' test scores before and after treatment were compared. The chemotherapy patients showed reduced performance on some of the neuropsychological tests compared to the radiotherapy group. This indicates a treatment related effect on the central nervous system, possibly caused by the combination chemotherapy.
Publication Date:
Jan 01, 1988
Product Type:
Journal Article
Reference Number:
SWED-88-000437; EDB-88-194947
Resource Relation:
Journal Name: Acta Oncol. (Stockh.); (Sweden); Journal Volume: 27:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; BIOLOGICAL RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; BEHAVIOR; BIOLOGICAL FUNCTIONS; CARCINOMAS; CHEMOTHERAPY; EFFICIENCY; LUNGS; PATIENTS; RESPIRATORY SYSTEM DISEASES; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; FUNCTIONS; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
6677735
Research Organizations:
Norwegian Cancer Society, Oslo; Norske Radiumhospital, Oslo. Dept. of Medical Oncology and Radiotherapy; Ulleval Sykehus, Oslo (Norway). Dept. of Neurosurgery; Institute for Social Research, Oslo (Norway)
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ACTOE
Submitting Site:
SWD
Size:
Pages: 241-246
Announcement Date:

Journal Article:

Citation Formats

Kaasa, S, Olsnes, B T, and Mastekaasa, A. Neuropsychological evaluation of patients with inoperable non-small cell lung cancer treated with combination chemotherapy or radiotherapy. Sweden: N. p., 1988. Web.
Kaasa, S, Olsnes, B T, & Mastekaasa, A. Neuropsychological evaluation of patients with inoperable non-small cell lung cancer treated with combination chemotherapy or radiotherapy. Sweden.
Kaasa, S, Olsnes, B T, and Mastekaasa, A. 1988. "Neuropsychological evaluation of patients with inoperable non-small cell lung cancer treated with combination chemotherapy or radiotherapy." Sweden.
@misc{etde_6677735,
title = {Neuropsychological evaluation of patients with inoperable non-small cell lung cancer treated with combination chemotherapy or radiotherapy}
author = {Kaasa, S, Olsnes, B T, and Mastekaasa, A}
abstractNote = {Neuropsychological tests were used to evaluate possible central nervous system dysfunction in patients treated with chemotherapy. Ninety-five patients with non-small cell lung cancer limited disease were randomized to either radiotherapy (2.8 Gyx15) or combination chemotherapy with cisplatin and etoposide. In order to evaluate cognitive functions three neuropsychological tests were applied: Trail Making, Benton Visual Retention Test and Verbal Learning. Changes in the patients' test scores before and after treatment were compared. The chemotherapy patients showed reduced performance on some of the neuropsychological tests compared to the radiotherapy group. This indicates a treatment related effect on the central nervous system, possibly caused by the combination chemotherapy.}
journal = {Acta Oncol. (Stockh.); (Sweden)}
volume = {27:3}
journal type = {AC}
place = {Sweden}
year = {1988}
month = {Jan}
}