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Effects of X-irradiation on axonal sprouting induced by botulinum toxin

Journal Article:

Abstract

The effect of X-irradiation on axonal sprouting of motor nerves induced by botulinum toxin was examined. Muscles of one leg in the mouse were X-irradiated (15Gy) prior to the injection of a locally paralysing dose of botulinum toxin. It was found that axonal sprouting occurred as expected, but the sprouts remained unmyelinated and many degenerated. Fewer new end-plates were formed, muscles remained more severely atrophied and supersensitive to acetylcholine and recovery of neuromuscular transmission was greatly delayed when compared with the effects of botulinum toxin alone. X-irradiation did not prevent sprouting but, probably by impairing Schwann cell proliferation, altered axon-Schwann cell relationships and prevented the maturation of newly-formed axons and the differentiation of new end-plates.
Authors:
Gomez, S; Duchen, L W; [1]  Hornsey, S [2] 
  1. National Hospital, London (UK)
  2. Hammersmith Hospital, London (UK). M.R.C. Cyclotron Unit
Publication Date:
Jan 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-710734; EDB-83-019143
Resource Relation:
Journal Name: Neuroscience; (United Kingdom); Journal Volume: 7:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NERVE CELLS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REGENERATION; MICE; MUSCLES; MYELIN; TOXINS; X RADIATION; ANIMAL CELLS; ANIMALS; ANTIGENS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; LIPIDS; LIPOPROTEINS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; PROTEINS; RADIATION EFFECTS; RADIATIONS; RECOVERY; RODENTS; SOMATIC CELLS; TOXIC MATERIALS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
6653088
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NRSCD
Submitting Site:
HEDB
Size:
Pages: 1023-1036
Announcement Date:

Journal Article:

Citation Formats

Gomez, S, Duchen, L W, and Hornsey, S. Effects of X-irradiation on axonal sprouting induced by botulinum toxin. United Kingdom: N. p., 1982. Web.
Gomez, S, Duchen, L W, & Hornsey, S. Effects of X-irradiation on axonal sprouting induced by botulinum toxin. United Kingdom.
Gomez, S, Duchen, L W, and Hornsey, S. 1982. "Effects of X-irradiation on axonal sprouting induced by botulinum toxin." United Kingdom.
@misc{etde_6653088,
title = {Effects of X-irradiation on axonal sprouting induced by botulinum toxin}
author = {Gomez, S, Duchen, L W, and Hornsey, S}
abstractNote = {The effect of X-irradiation on axonal sprouting of motor nerves induced by botulinum toxin was examined. Muscles of one leg in the mouse were X-irradiated (15Gy) prior to the injection of a locally paralysing dose of botulinum toxin. It was found that axonal sprouting occurred as expected, but the sprouts remained unmyelinated and many degenerated. Fewer new end-plates were formed, muscles remained more severely atrophied and supersensitive to acetylcholine and recovery of neuromuscular transmission was greatly delayed when compared with the effects of botulinum toxin alone. X-irradiation did not prevent sprouting but, probably by impairing Schwann cell proliferation, altered axon-Schwann cell relationships and prevented the maturation of newly-formed axons and the differentiation of new end-plates.}
journal = {Neuroscience; (United Kingdom)}
volume = {7:4}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Jan}
}