Abstract
The effect of X-irradiation on axonal sprouting of motor nerves induced by botulinum toxin was examined. Muscles of one leg in the mouse were X-irradiated (15Gy) prior to the injection of a locally paralysing dose of botulinum toxin. It was found that axonal sprouting occurred as expected, but the sprouts remained unmyelinated and many degenerated. Fewer new end-plates were formed, muscles remained more severely atrophied and supersensitive to acetylcholine and recovery of neuromuscular transmission was greatly delayed when compared with the effects of botulinum toxin alone. X-irradiation did not prevent sprouting but, probably by impairing Schwann cell proliferation, altered axon-Schwann cell relationships and prevented the maturation of newly-formed axons and the differentiation of new end-plates.
Gomez, S;
Duchen, L W;
[1]
Hornsey, S
[2]
- National Hospital, London (UK)
- Hammersmith Hospital, London (UK). M.R.C. Cyclotron Unit
Citation Formats
Gomez, S, Duchen, L W, and Hornsey, S.
Effects of X-irradiation on axonal sprouting induced by botulinum toxin.
United Kingdom: N. p.,
1982.
Web.
Gomez, S, Duchen, L W, & Hornsey, S.
Effects of X-irradiation on axonal sprouting induced by botulinum toxin.
United Kingdom.
Gomez, S, Duchen, L W, and Hornsey, S.
1982.
"Effects of X-irradiation on axonal sprouting induced by botulinum toxin."
United Kingdom.
@misc{etde_6653088,
title = {Effects of X-irradiation on axonal sprouting induced by botulinum toxin}
author = {Gomez, S, Duchen, L W, and Hornsey, S}
abstractNote = {The effect of X-irradiation on axonal sprouting of motor nerves induced by botulinum toxin was examined. Muscles of one leg in the mouse were X-irradiated (15Gy) prior to the injection of a locally paralysing dose of botulinum toxin. It was found that axonal sprouting occurred as expected, but the sprouts remained unmyelinated and many degenerated. Fewer new end-plates were formed, muscles remained more severely atrophied and supersensitive to acetylcholine and recovery of neuromuscular transmission was greatly delayed when compared with the effects of botulinum toxin alone. X-irradiation did not prevent sprouting but, probably by impairing Schwann cell proliferation, altered axon-Schwann cell relationships and prevented the maturation of newly-formed axons and the differentiation of new end-plates.}
journal = []
volume = {7:4}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Jan}
}
title = {Effects of X-irradiation on axonal sprouting induced by botulinum toxin}
author = {Gomez, S, Duchen, L W, and Hornsey, S}
abstractNote = {The effect of X-irradiation on axonal sprouting of motor nerves induced by botulinum toxin was examined. Muscles of one leg in the mouse were X-irradiated (15Gy) prior to the injection of a locally paralysing dose of botulinum toxin. It was found that axonal sprouting occurred as expected, but the sprouts remained unmyelinated and many degenerated. Fewer new end-plates were formed, muscles remained more severely atrophied and supersensitive to acetylcholine and recovery of neuromuscular transmission was greatly delayed when compared with the effects of botulinum toxin alone. X-irradiation did not prevent sprouting but, probably by impairing Schwann cell proliferation, altered axon-Schwann cell relationships and prevented the maturation of newly-formed axons and the differentiation of new end-plates.}
journal = []
volume = {7:4}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Jan}
}