Abstract
(-)-Norepinephrine is the predominant neurotransmitter of the sympathetic innervation of the heart. Racemic norepinephrine was labelled with carbon-11 and injected i.v. into Cynomolgus monkeys. Five minutes after injection there was a more than tenfold higher radioactivity in the heart than in adjacent tissue. Pretreatment with the norepinephrine reuptake inhibitor desipramine reduced the uptake by more than 80%. The high specific uptake of racemic [[sup 11]C]norepinephrine indicates that enatiomerically pure(-)-[[sup 11]C]norepinephrine has promising potential for detailed mapping of the sympathetic innervation of the human myocardium. (orig.)
Farde, L;
[1]
Halldin, C;
[1]
Naagren, K;
[2]
Suhara, Tetsuya;
[1]
Karlsson, P;
[1]
Schoeps, K O;
[1]
Swahn, C G;
[1]
Bone, D
[1]
- Dept. of Clinical Neuroscience, Karolinska Inst., Stockholm (Sweden)
- Turku Univ., Cyclotron/PET Center (Finland)
Citation Formats
Farde, L, Halldin, C, Naagren, K, Suhara, Tetsuya, Karlsson, P, Schoeps, K O, Swahn, C G, and Bone, D.
Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart.
Germany: N. p.,
1994.
Web.
doi:10.1007/BF00947971.
Farde, L, Halldin, C, Naagren, K, Suhara, Tetsuya, Karlsson, P, Schoeps, K O, Swahn, C G, & Bone, D.
Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart.
Germany.
https://doi.org/10.1007/BF00947971
Farde, L, Halldin, C, Naagren, K, Suhara, Tetsuya, Karlsson, P, Schoeps, K O, Swahn, C G, and Bone, D.
1994.
"Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart."
Germany.
https://doi.org/10.1007/BF00947971.
@misc{etde_6650711,
title = {Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart}
author = {Farde, L, Halldin, C, Naagren, K, Suhara, Tetsuya, Karlsson, P, Schoeps, K O, Swahn, C G, and Bone, D}
abstractNote = {(-)-Norepinephrine is the predominant neurotransmitter of the sympathetic innervation of the heart. Racemic norepinephrine was labelled with carbon-11 and injected i.v. into Cynomolgus monkeys. Five minutes after injection there was a more than tenfold higher radioactivity in the heart than in adjacent tissue. Pretreatment with the norepinephrine reuptake inhibitor desipramine reduced the uptake by more than 80%. The high specific uptake of racemic [[sup 11]C]norepinephrine indicates that enatiomerically pure(-)-[[sup 11]C]norepinephrine has promising potential for detailed mapping of the sympathetic innervation of the human myocardium. (orig.)}
doi = {10.1007/BF00947971}
journal = []
volume = {21:4}
journal type = {AC}
place = {Germany}
year = {1994}
month = {Apr}
}
title = {Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart}
author = {Farde, L, Halldin, C, Naagren, K, Suhara, Tetsuya, Karlsson, P, Schoeps, K O, Swahn, C G, and Bone, D}
abstractNote = {(-)-Norepinephrine is the predominant neurotransmitter of the sympathetic innervation of the heart. Racemic norepinephrine was labelled with carbon-11 and injected i.v. into Cynomolgus monkeys. Five minutes after injection there was a more than tenfold higher radioactivity in the heart than in adjacent tissue. Pretreatment with the norepinephrine reuptake inhibitor desipramine reduced the uptake by more than 80%. The high specific uptake of racemic [[sup 11]C]norepinephrine indicates that enatiomerically pure(-)-[[sup 11]C]norepinephrine has promising potential for detailed mapping of the sympathetic innervation of the human myocardium. (orig.)}
doi = {10.1007/BF00947971}
journal = []
volume = {21:4}
journal type = {AC}
place = {Germany}
year = {1994}
month = {Apr}
}