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Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14, and MMS19

Journal Article:

Abstract

The ability to remove ultraviolet (uv)-induced pyrimidine dimers from the nuclear DNA of yeast was examined in two radiation-sensitive (rad) mutants and one methyl methanesulfonate-sensitive (mms) mutant of the yeast Saccharomyces cerevisiae. The susceptibility of DNA from irradiated cells to nicking by an endonuclease activity prepared from crude extracts of Micrococcus luteus was used to measure the presence of dimers in DNA. The rad7, rad14, and mms19 mutants were found to be defective in their ability to remove uv-induced dimers from nuclear DNA. All three mutants belong to the same episatic group as the other mutants involved in excision-repair. All three mutants show enhanced uv-induced mutations. The rad 14 mutant also shows epistatic interactions with genes in the other two uv repair pathways.
Publication Date:
Jan 01, 1979
Product Type:
Journal Article
Reference Number:
ERA-06-014866; EDB-81-041512
Resource Relation:
Journal Name: Mol. Gen. Genet.; (Germany, Federal Republic of); Journal Volume: 176
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; DNA; BIOLOGICAL REPAIR; SACCHAROMYCES CEREVISIAE; BIOLOGICAL RADIATION EFFECTS; BIOCHEMISTRY; DIMERS; GENES; GENETICS; MICROCOCCUS LUTEUS; MUTANTS; MUTATIONS; PYRIMIDINES; RADIOINDUCTION; RADIOSENSITIVITY; STRAND BREAKS; ULTRAVIOLET RADIATION; AZINES; BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BIOLOGY; CHEMISTRY; ELECTROMAGNETIC RADIATION; FUNGI; HETEROCYCLIC COMPOUNDS; MICROCOCCUS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; SACCHAROMYCES; YEASTS; 560112* - Radiation Effects on Biochemicals- In Microorganisms- (-1987); 560131 - Radiation Effects on Microorganisms- Basic Studies- (-1987); 550200 - Biochemistry; 550400 - Genetics
OSTI ID:
6642793
Research Organizations:
Univ. of Rochester, NY
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MGGEA
Submitting Site:
TIC
Size:
Pages: 351-359
Announcement Date:

Journal Article:

Citation Formats

Prakash, L, and Prakash, S. Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14, and MMS19. Germany: N. p., 1979. Web.
Prakash, L, & Prakash, S. Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14, and MMS19. Germany.
Prakash, L, and Prakash, S. 1979. "Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14, and MMS19." Germany.
@misc{etde_6642793,
title = {Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14, and MMS19}
author = {Prakash, L, and Prakash, S}
abstractNote = {The ability to remove ultraviolet (uv)-induced pyrimidine dimers from the nuclear DNA of yeast was examined in two radiation-sensitive (rad) mutants and one methyl methanesulfonate-sensitive (mms) mutant of the yeast Saccharomyces cerevisiae. The susceptibility of DNA from irradiated cells to nicking by an endonuclease activity prepared from crude extracts of Micrococcus luteus was used to measure the presence of dimers in DNA. The rad7, rad14, and mms19 mutants were found to be defective in their ability to remove uv-induced dimers from nuclear DNA. All three mutants belong to the same episatic group as the other mutants involved in excision-repair. All three mutants show enhanced uv-induced mutations. The rad 14 mutant also shows epistatic interactions with genes in the other two uv repair pathways.}
journal = {Mol. Gen. Genet.; (Germany, Federal Republic of)}
volume = {176}
journal type = {AC}
place = {Germany}
year = {1979}
month = {Jan}
}