Abstract
Splenic immune responses having varying dependence on accessory cell cooperation have been studied after infection of mice with Friend virus. Infection had no effect on cell proliferation or antibody production in cultures stimulated with E.coli lipopolysaccharide. The response in vivo to type III pneumococcal polysaccharide was depressed only moderately. The response to sheep red blood cells was depressed severely both in vivo and in vitro. Depression in vitro was greatly reduced by co-stimulation with E.coli lipopolysaccharide. Depletion of potential suppressor lymphocyte populations by irradiation or adult thymectomy did not ameliorate depression of responses to sheep red blood cells or pneumococcal polysaccharide. Responses after adult thymectomy plus irradiation were not affected by the virus. Although it is known that macrophage and helper T-lymphocyte cooperation are not themselves impaired by infection, these results suggest that there is a direct relationship between severity of immune depression and dependence on cooperation. Implications for the action of the virus are discussed.
Citation Formats
Dracott, B N, Wedderburn, N, and Doenhoff, M J.
Immunodepressive effect of Friend virus. 4. Effects on spleen B lymphocytes.
United Kingdom: N. p.,
1978.
Web.
Dracott, B N, Wedderburn, N, & Doenhoff, M J.
Immunodepressive effect of Friend virus. 4. Effects on spleen B lymphocytes.
United Kingdom.
Dracott, B N, Wedderburn, N, and Doenhoff, M J.
1978.
"Immunodepressive effect of Friend virus. 4. Effects on spleen B lymphocytes."
United Kingdom.
@misc{etde_6641063,
title = {Immunodepressive effect of Friend virus. 4. Effects on spleen B lymphocytes}
author = {Dracott, B N, Wedderburn, N, and Doenhoff, M J}
abstractNote = {Splenic immune responses having varying dependence on accessory cell cooperation have been studied after infection of mice with Friend virus. Infection had no effect on cell proliferation or antibody production in cultures stimulated with E.coli lipopolysaccharide. The response in vivo to type III pneumococcal polysaccharide was depressed only moderately. The response to sheep red blood cells was depressed severely both in vivo and in vitro. Depression in vitro was greatly reduced by co-stimulation with E.coli lipopolysaccharide. Depletion of potential suppressor lymphocyte populations by irradiation or adult thymectomy did not ameliorate depression of responses to sheep red blood cells or pneumococcal polysaccharide. Responses after adult thymectomy plus irradiation were not affected by the virus. Although it is known that macrophage and helper T-lymphocyte cooperation are not themselves impaired by infection, these results suggest that there is a direct relationship between severity of immune depression and dependence on cooperation. Implications for the action of the virus are discussed.}
journal = []
volume = {34:4}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Apr}
}
title = {Immunodepressive effect of Friend virus. 4. Effects on spleen B lymphocytes}
author = {Dracott, B N, Wedderburn, N, and Doenhoff, M J}
abstractNote = {Splenic immune responses having varying dependence on accessory cell cooperation have been studied after infection of mice with Friend virus. Infection had no effect on cell proliferation or antibody production in cultures stimulated with E.coli lipopolysaccharide. The response in vivo to type III pneumococcal polysaccharide was depressed only moderately. The response to sheep red blood cells was depressed severely both in vivo and in vitro. Depression in vitro was greatly reduced by co-stimulation with E.coli lipopolysaccharide. Depletion of potential suppressor lymphocyte populations by irradiation or adult thymectomy did not ameliorate depression of responses to sheep red blood cells or pneumococcal polysaccharide. Responses after adult thymectomy plus irradiation were not affected by the virus. Although it is known that macrophage and helper T-lymphocyte cooperation are not themselves impaired by infection, these results suggest that there is a direct relationship between severity of immune depression and dependence on cooperation. Implications for the action of the virus are discussed.}
journal = []
volume = {34:4}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Apr}
}