Abstract
The percutaneous penetration of [sup 3]H-huangbai extracts and [sup 3]H-berberine through excised guinea pig and human shins was studied using the static diffusion cell technique. The data were treated with mathematical model of skin absorption. The results showed that huangbai extracts and berberine could penetrate the guinea pig and human skins at (above) dose of 8.38 [mu]g/cm[sup 2] and 14.32 [mu]g/cm[sup 2], respectively. The amount and rate of penetration increased linearly with the time of exposure and dose. The permeability of berberine through guinea pig and human skins in two vehicles (water and glycol) was lower than that of huangbai extracts. When Huangbai extracts and berberine were applied in glycol solution, the vehicle greatly enhanced the penetration of the two penetrant. The lag time of two penetrant through human skin was longer than that through guinea pig skin.
Xipeng, Jin;
Xiaozhong, Yu;
[1]
Nianbao, Zhang;
Jianwen, Kuang
[2]
- School of Public Health, Shanghai Medical Univ. (China)
- Shanghai Inst. of Nuclear Research Acdemic Sinica (China)
Citation Formats
Xipeng, Jin, Xiaozhong, Yu, Nianbao, Zhang, and Jianwen, Kuang.
Percutaneous penetration of [sup 3]H-Huangbai extracts and H[sup 3]-berberine.
China: N. p.,
1992.
Web.
Xipeng, Jin, Xiaozhong, Yu, Nianbao, Zhang, & Jianwen, Kuang.
Percutaneous penetration of [sup 3]H-Huangbai extracts and H[sup 3]-berberine.
China.
Xipeng, Jin, Xiaozhong, Yu, Nianbao, Zhang, and Jianwen, Kuang.
1992.
"Percutaneous penetration of [sup 3]H-Huangbai extracts and H[sup 3]-berberine."
China.
@misc{etde_6623545,
title = {Percutaneous penetration of [sup 3]H-Huangbai extracts and H[sup 3]-berberine}
author = {Xipeng, Jin, Xiaozhong, Yu, Nianbao, Zhang, and Jianwen, Kuang}
abstractNote = {The percutaneous penetration of [sup 3]H-huangbai extracts and [sup 3]H-berberine through excised guinea pig and human shins was studied using the static diffusion cell technique. The data were treated with mathematical model of skin absorption. The results showed that huangbai extracts and berberine could penetrate the guinea pig and human skins at (above) dose of 8.38 [mu]g/cm[sup 2] and 14.32 [mu]g/cm[sup 2], respectively. The amount and rate of penetration increased linearly with the time of exposure and dose. The permeability of berberine through guinea pig and human skins in two vehicles (water and glycol) was lower than that of huangbai extracts. When Huangbai extracts and berberine were applied in glycol solution, the vehicle greatly enhanced the penetration of the two penetrant. The lag time of two penetrant through human skin was longer than that through guinea pig skin.}
journal = []
volume = {5:1}
journal type = {AC}
place = {China}
year = {1992}
month = {Feb}
}
title = {Percutaneous penetration of [sup 3]H-Huangbai extracts and H[sup 3]-berberine}
author = {Xipeng, Jin, Xiaozhong, Yu, Nianbao, Zhang, and Jianwen, Kuang}
abstractNote = {The percutaneous penetration of [sup 3]H-huangbai extracts and [sup 3]H-berberine through excised guinea pig and human shins was studied using the static diffusion cell technique. The data were treated with mathematical model of skin absorption. The results showed that huangbai extracts and berberine could penetrate the guinea pig and human skins at (above) dose of 8.38 [mu]g/cm[sup 2] and 14.32 [mu]g/cm[sup 2], respectively. The amount and rate of penetration increased linearly with the time of exposure and dose. The permeability of berberine through guinea pig and human skins in two vehicles (water and glycol) was lower than that of huangbai extracts. When Huangbai extracts and berberine were applied in glycol solution, the vehicle greatly enhanced the penetration of the two penetrant. The lag time of two penetrant through human skin was longer than that through guinea pig skin.}
journal = []
volume = {5:1}
journal type = {AC}
place = {China}
year = {1992}
month = {Feb}
}