Abstract
Previously, resistance of malaria parasite to chloroquine has been restricted only to Plasmodium falciparum. Recently, there have been many reports of chloroquine-resistant Plasmodium vivax. One of the mechanisms of chloroquine resistance is the decreased uptake of chloroquine or rapid efflux of the drug from the food vacuole of the parasite. In this study, we have measured the rapid efflux of IH-chloroquine in fifty blood samples from patients with P Vivax infection. All 50 patients were hospitalised for 28 days for the standard treatment with chloroquine. It was found that seven patients who did not respond to the standard regimen of chloroquine have parasites with rapid effluxes of IH-chloroquine. Since rapid effluxes of IH-chloroquine in the resistant parasites showed strong correlation with in vivo 28 days clinical trial, this assay could be used as rapid assessment of chloroquine resistance in patients with P vivax infection.
Citation Formats
Oo, Myint, Khin, Myo, and Oo, Nwe Nwe.
Development of in-vitro radiometric assay for the rapid assessment of chloroquine resistant plasmodium vivax.
Malaysia: N. p.,
1997.
Web.
Oo, Myint, Khin, Myo, & Oo, Nwe Nwe.
Development of in-vitro radiometric assay for the rapid assessment of chloroquine resistant plasmodium vivax.
Malaysia.
Oo, Myint, Khin, Myo, and Oo, Nwe Nwe.
1997.
"Development of in-vitro radiometric assay for the rapid assessment of chloroquine resistant plasmodium vivax."
Malaysia.
@misc{etde_662201,
title = {Development of in-vitro radiometric assay for the rapid assessment of chloroquine resistant plasmodium vivax}
author = {Oo, Myint, Khin, Myo, and Oo, Nwe Nwe}
abstractNote = {Previously, resistance of malaria parasite to chloroquine has been restricted only to Plasmodium falciparum. Recently, there have been many reports of chloroquine-resistant Plasmodium vivax. One of the mechanisms of chloroquine resistance is the decreased uptake of chloroquine or rapid efflux of the drug from the food vacuole of the parasite. In this study, we have measured the rapid efflux of IH-chloroquine in fifty blood samples from patients with P Vivax infection. All 50 patients were hospitalised for 28 days for the standard treatment with chloroquine. It was found that seven patients who did not respond to the standard regimen of chloroquine have parasites with rapid effluxes of IH-chloroquine. Since rapid effluxes of IH-chloroquine in the resistant parasites showed strong correlation with in vivo 28 days clinical trial, this assay could be used as rapid assessment of chloroquine resistance in patients with P vivax infection.}
place = {Malaysia}
year = {1997}
month = {Dec}
}
title = {Development of in-vitro radiometric assay for the rapid assessment of chloroquine resistant plasmodium vivax}
author = {Oo, Myint, Khin, Myo, and Oo, Nwe Nwe}
abstractNote = {Previously, resistance of malaria parasite to chloroquine has been restricted only to Plasmodium falciparum. Recently, there have been many reports of chloroquine-resistant Plasmodium vivax. One of the mechanisms of chloroquine resistance is the decreased uptake of chloroquine or rapid efflux of the drug from the food vacuole of the parasite. In this study, we have measured the rapid efflux of IH-chloroquine in fifty blood samples from patients with P Vivax infection. All 50 patients were hospitalised for 28 days for the standard treatment with chloroquine. It was found that seven patients who did not respond to the standard regimen of chloroquine have parasites with rapid effluxes of IH-chloroquine. Since rapid effluxes of IH-chloroquine in the resistant parasites showed strong correlation with in vivo 28 days clinical trial, this assay could be used as rapid assessment of chloroquine resistance in patients with P vivax infection.}
place = {Malaysia}
year = {1997}
month = {Dec}
}