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Progressive supranuclear palsy dopamine D2 receptor tomoscintigraphy to detect L-dopamine efficiency. Paralysies supra-nucleaires progressives. Quantification des recepteurs dopaminergiques D2 par tomoscintigraphie

Journal Article:

Abstract

Progressive supranuclear palsy (PSP) may sometimes be misdiagnosed as Parkinson's disease in its early stages, hence an early positive diagnosis of PSP based on dopamine D2 receptor density could be extremely valuable. In the present case report, the absence of dopamine D2 receptors was clearly demonstrated in the striatum using [sup 123]I-iodobenzamide (IBZM) tomoscintigraphy. This illustrates the potential use of IBZM tomoscintigraphy to identify Parkinson-like's disease presenting with decreased dopamine D2 receptor density; and hence to predict L-Dopa effectiveness. Further studies are needed to evaluate the value of IBZM tomoscintigraphy in the different Parkinson's like diseases. (authors). 11 refs., 2 figs.
Authors:
Tranquart, F; Henry Le Bras, F; Toffol, B de; Autret, A; Guilloteau, D; Baulieu, J L [1] 
  1. Hopital Bretonneau, 37 - Tours (France)
Publication Date:
Sep 01, 1994
Product Type:
Journal Article
Reference Number:
AIX-26-021303; EDB-95-046942
Resource Relation:
Journal Name: Presse Medicale (1983); (France); Journal Volume: 23:28
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; SCINTISCANNING; DOPAMINE; RECEPTORS; TOMOGRAPHY; BRAIN; DIAGNOSIS; GAMMA CAMERAS; IODINE 123; LABELLED COMPOUNDS; MEDICAL EXAMINATIONS; NUCLEAR MEDICINE; POSITRON COMPUTED TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM 99; TRACER TECHNIQUES; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CAMERAS; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MEDICINE; MEMBRANE PROTEINS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPATHOMIMETICS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOI; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6618396
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: CODEN: PRMEEM
Submitting Site:
FRN
Size:
Pages: 1299-1300
Announcement Date:

Journal Article:

Citation Formats

Tranquart, F, Henry Le Bras, F, Toffol, B de, Autret, A, Guilloteau, D, and Baulieu, J L. Progressive supranuclear palsy dopamine D2 receptor tomoscintigraphy to detect L-dopamine efficiency. Paralysies supra-nucleaires progressives. Quantification des recepteurs dopaminergiques D2 par tomoscintigraphie. France: N. p., 1994. Web.
Tranquart, F, Henry Le Bras, F, Toffol, B de, Autret, A, Guilloteau, D, & Baulieu, J L. Progressive supranuclear palsy dopamine D2 receptor tomoscintigraphy to detect L-dopamine efficiency. Paralysies supra-nucleaires progressives. Quantification des recepteurs dopaminergiques D2 par tomoscintigraphie. France.
Tranquart, F, Henry Le Bras, F, Toffol, B de, Autret, A, Guilloteau, D, and Baulieu, J L. 1994. "Progressive supranuclear palsy dopamine D2 receptor tomoscintigraphy to detect L-dopamine efficiency. Paralysies supra-nucleaires progressives. Quantification des recepteurs dopaminergiques D2 par tomoscintigraphie." France.
@misc{etde_6618396,
title = {Progressive supranuclear palsy dopamine D2 receptor tomoscintigraphy to detect L-dopamine efficiency. Paralysies supra-nucleaires progressives. Quantification des recepteurs dopaminergiques D2 par tomoscintigraphie}
author = {Tranquart, F, Henry Le Bras, F, Toffol, B de, Autret, A, Guilloteau, D, and Baulieu, J L}
abstractNote = {Progressive supranuclear palsy (PSP) may sometimes be misdiagnosed as Parkinson's disease in its early stages, hence an early positive diagnosis of PSP based on dopamine D2 receptor density could be extremely valuable. In the present case report, the absence of dopamine D2 receptors was clearly demonstrated in the striatum using [sup 123]I-iodobenzamide (IBZM) tomoscintigraphy. This illustrates the potential use of IBZM tomoscintigraphy to identify Parkinson-like's disease presenting with decreased dopamine D2 receptor density; and hence to predict L-Dopa effectiveness. Further studies are needed to evaluate the value of IBZM tomoscintigraphy in the different Parkinson's like diseases. (authors). 11 refs., 2 figs.}
journal = {Presse Medicale (1983); (France)}
volume = {23:28}
journal type = {AC}
place = {France}
year = {1994}
month = {Sep}
}