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Effects of X-irradiation alone and in combination with ACNU on human glioblastoma cells in vitro

Journal Article:

Abstract

The combined effects of x-irradiation and 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloro-ethyl)-3-nitrosourea (ACNU) on multicellular glioblastoma A-7 spheroids were analyzed by means of cell survival and dose-response curves. The actual dose-response curve for small spheroids was almost identical to that estimated from the cell survival curve. It was strongly suggested that a small number of radiation-resistant cells, which were not detected in the cell survival curve, were present in large spheroids with central necrosis. The enhancing effect of ACNU was greater with large spheroids than with monolayer cells or small spheroids. A possible explanation for this is that ACNU is higher effective against the few radiation-resistant cells that may be present in larger spheroids. (author).
Authors:
Mashiyama, Shoji; Katakura, Ryuichi; Takahashi, Kou; Kitahara, Masakazu; Suzuki, Jiro; [1]  Sasaki, Takehito
  1. Tohoku Univ., Sendai (Japan). School of Medicine
Publication Date:
May 01, 1990
Product Type:
Journal Article
Reference Number:
JPN-90-009361; EDB-90-160295
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 30:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NITROSOUREAS; RADIOSENSITIVITY; ANOXIA; ANTINEOPLASTIC DRUGS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL NEOPLASMS; GLIOMAS; MICE; RADIATION DOSES; SURVIVAL CURVES; TUMOR CELLS; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; NITROSO COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 560152 - Radiation Effects on Animals- Animals
OSTI ID:
6616264
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 295-300
Announcement Date:
Nov 01, 1990

Journal Article:

Citation Formats

Mashiyama, Shoji, Katakura, Ryuichi, Takahashi, Kou, Kitahara, Masakazu, Suzuki, Jiro, and Sasaki, Takehito. Effects of X-irradiation alone and in combination with ACNU on human glioblastoma cells in vitro. Japan: N. p., 1990. Web.
Mashiyama, Shoji, Katakura, Ryuichi, Takahashi, Kou, Kitahara, Masakazu, Suzuki, Jiro, & Sasaki, Takehito. Effects of X-irradiation alone and in combination with ACNU on human glioblastoma cells in vitro. Japan.
Mashiyama, Shoji, Katakura, Ryuichi, Takahashi, Kou, Kitahara, Masakazu, Suzuki, Jiro, and Sasaki, Takehito. 1990. "Effects of X-irradiation alone and in combination with ACNU on human glioblastoma cells in vitro." Japan.
@misc{etde_6616264,
title = {Effects of X-irradiation alone and in combination with ACNU on human glioblastoma cells in vitro}
author = {Mashiyama, Shoji, Katakura, Ryuichi, Takahashi, Kou, Kitahara, Masakazu, Suzuki, Jiro, and Sasaki, Takehito}
abstractNote = {The combined effects of x-irradiation and 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloro-ethyl)-3-nitrosourea (ACNU) on multicellular glioblastoma A-7 spheroids were analyzed by means of cell survival and dose-response curves. The actual dose-response curve for small spheroids was almost identical to that estimated from the cell survival curve. It was strongly suggested that a small number of radiation-resistant cells, which were not detected in the cell survival curve, were present in large spheroids with central necrosis. The enhancing effect of ACNU was greater with large spheroids than with monolayer cells or small spheroids. A possible explanation for this is that ACNU is higher effective against the few radiation-resistant cells that may be present in larger spheroids. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {30:5}
journal type = {AC}
place = {Japan}
year = {1990}
month = {May}
}