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Preliminary clinical experience of pulmonary scintigraphy using [sup 131]I-HIPDM

Abstract

The metabolic imaging of lungs using [sup 131]I-HIPDM, a tracer known to bind to the amino-receptor in pancreas and lungs, was carried out on 44 subjects. In the normal non-smoker group (n = 8), the tracer was found to be uniformly distributed throughout the lung, with slow clearance in bi-exponential mode after peak of concentration in about 30 sec; while in the normal smoker (n = 8), patients with chronic obstructive pulmonary disease (COPD) of both smoker (n = 7) and non-smoker (n = 12), and patients with asthma (n = 5), the distribution as well as the parameters of clearance of [sup 131]I-HIPDM were significantly different. In conclusion: (1) [sup 131]I-HEPDM could reveal some characteristics of pulmonary metabolism of amine in various physiological as well as pathological status; (2) the washout of the tracer from lung was correlated with clinical ventilation functions; (3) smoking is one of the determinant factors of lung metabolic function; (4) the pulmonary metabolic imaging using [sup 131]I-HIPDM was of value in detecting lung disease, especially the functional damages caused by various factors.
Authors:
Jiahe, Tian [1] 
  1. Department of Medicine, The Chinese PLA General Hospital, Beijing (China); and others
Publication Date:
Feb 01, 1992
Product Type:
Journal Article
Reference Number:
AIX-24-038281; EDB-93-066169
Resource Relation:
Journal Name: Chinese Journal of Nuclear Medicine (Zhonghua Heyixue Zazhi); (China); Journal Volume: 12:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LUNGS; CONTRAST MEDIA; IMAGES; BIOLOGICAL FUNCTIONS; IODINE 131; LABELLED COMPOUNDS; NEOPLASMS; PATIENTS; RESPIRATORY SYSTEM DISEASES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RESPIRATORY SYSTEM; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6613268
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 0253-9780; CODEN: CITCDE
Submitting Site:
INIS
Size:
Pages: 32-34
Announcement Date:
Jun 01, 1993

Citation Formats

Jiahe, Tian. Preliminary clinical experience of pulmonary scintigraphy using [sup 131]I-HIPDM. China: N. p., 1992. Web.
Jiahe, Tian. Preliminary clinical experience of pulmonary scintigraphy using [sup 131]I-HIPDM. China.
Jiahe, Tian. 1992. "Preliminary clinical experience of pulmonary scintigraphy using [sup 131]I-HIPDM." China.
@misc{etde_6613268,
title = {Preliminary clinical experience of pulmonary scintigraphy using [sup 131]I-HIPDM}
author = {Jiahe, Tian}
abstractNote = {The metabolic imaging of lungs using [sup 131]I-HIPDM, a tracer known to bind to the amino-receptor in pancreas and lungs, was carried out on 44 subjects. In the normal non-smoker group (n = 8), the tracer was found to be uniformly distributed throughout the lung, with slow clearance in bi-exponential mode after peak of concentration in about 30 sec; while in the normal smoker (n = 8), patients with chronic obstructive pulmonary disease (COPD) of both smoker (n = 7) and non-smoker (n = 12), and patients with asthma (n = 5), the distribution as well as the parameters of clearance of [sup 131]I-HIPDM were significantly different. In conclusion: (1) [sup 131]I-HEPDM could reveal some characteristics of pulmonary metabolism of amine in various physiological as well as pathological status; (2) the washout of the tracer from lung was correlated with clinical ventilation functions; (3) smoking is one of the determinant factors of lung metabolic function; (4) the pulmonary metabolic imaging using [sup 131]I-HIPDM was of value in detecting lung disease, especially the functional damages caused by various factors.}
journal = []
volume = {12:1}
journal type = {AC}
place = {China}
year = {1992}
month = {Feb}
}