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Acute effect of methyl bromide on sleep-wakefulness and its

Journal Article:

Abstract

In an attempt to clarify the acute effects of methyl bromide on the central nervous system, abnormal electrocorticographic activity and changes in sleep-wakefulness and its circadian rhythms were investigated after a single injection of methyl bromide. The effects of possible hydrolyzed products of methyl bromide, methanol and bromine ions on sleep and its rhythms were also examined. It was found that the hydrolyzed products of methyl bromide, bromine ions and methanol exerted little effect on the amounts of wakefulness (W), non-REM sleep (NREMS) and REM sleep (REMS) at the same molar dose as 45 mg methyl bromide/kg. Thus, it can be concluded that the methyl bromide-induced changes in sleep-wakefulness and its circadian rhythms are due to methyl bromide and not to the hydrolyzed products. It was also found that amounts of W, NREMS and REMS were changed dose-dependently after a single injection of methyl bromide and that methyl bromide significantly disrupted the circadian REMS rhythm. 17 references, 1 figure, 1 table.
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
EDB-87-099097
Resource Relation:
Journal Name: Ind. Health (Kawasaki); (Japan); Journal Volume: 24:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CENTRAL NERVOUS SYSTEM; SENSITIVITY; METHANOL; TOXICITY; METHYL BROMIDE; SLEEP; DAILY VARIATIONS; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; INSECTICIDES; RATS; ALCOHOLS; ANIMALS; BROMINATED ALIPHATIC HYDROCARBONS; DATA; HALOGENATED ALIPHATIC HYDROCARBONS; HYDROXY COMPOUNDS; INFORMATION; MAMMALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; PESTICIDES; RODENTS; VARIATIONS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology
OSTI ID:
6608726
Research Organizations:
Kitasato Univ., Kanagawa, Japan
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: INHEA
Submitting Site:
JMT
Size:
Pages: 249-253
Announcement Date:

Journal Article:

Citation Formats

Tanaka, S, Arito, H, Abuku, S, and Imamiya, S. Acute effect of methyl bromide on sleep-wakefulness and its. Japan: N. p., 1986. Web.
Tanaka, S, Arito, H, Abuku, S, & Imamiya, S. Acute effect of methyl bromide on sleep-wakefulness and its. Japan.
Tanaka, S, Arito, H, Abuku, S, and Imamiya, S. 1986. "Acute effect of methyl bromide on sleep-wakefulness and its." Japan.
@misc{etde_6608726,
title = {Acute effect of methyl bromide on sleep-wakefulness and its}
author = {Tanaka, S, Arito, H, Abuku, S, and Imamiya, S}
abstractNote = {In an attempt to clarify the acute effects of methyl bromide on the central nervous system, abnormal electrocorticographic activity and changes in sleep-wakefulness and its circadian rhythms were investigated after a single injection of methyl bromide. The effects of possible hydrolyzed products of methyl bromide, methanol and bromine ions on sleep and its rhythms were also examined. It was found that the hydrolyzed products of methyl bromide, bromine ions and methanol exerted little effect on the amounts of wakefulness (W), non-REM sleep (NREMS) and REM sleep (REMS) at the same molar dose as 45 mg methyl bromide/kg. Thus, it can be concluded that the methyl bromide-induced changes in sleep-wakefulness and its circadian rhythms are due to methyl bromide and not to the hydrolyzed products. It was also found that amounts of W, NREMS and REMS were changed dose-dependently after a single injection of methyl bromide and that methyl bromide significantly disrupted the circadian REMS rhythm. 17 references, 1 figure, 1 table.}
journal = {Ind. Health (Kawasaki); (Japan)}
volume = {24:4}
journal type = {AC}
place = {Japan}
year = {1986}
month = {Jan}
}