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Radiotherapy for leukemia in children, (1). Radiotherapy for central nervous system leukemia

Journal Article:

Abstract

Following the development of effective chemotherapy for producing remissions of acute lymphocytic leukemia (ALL), a new phenomenon has emerged in this disease--central nervous system (CNS) leukemia. CNS leukemia has become an increasingly frequent obstacle to prolongation of initial complete remission. Prophylactic irradiation of the CNS concomitant with intrathecal administration of methotrexate (IT-MTX) has proved to be effective in the reduction of CNS involvement. The purpose of this paper is to describe the results of irradiation for prevention of CNS leukemia and to discuss their implications. The patients consisted of 32 children with acute leukemia, admitted to MAIZURU National Hospital from 1966 to 1980; 22 patients of them had ALL, the others ANLL (acute non-lymphocytic leukemia). Preventive CNS therapy was started in 1974, (group A), but there was no prevention before 1974 (group B). 1. In group B, six patients was treated by therapeutic cranial irradiation, but all cases resulted in death. 2. In group A, seven patients was treated by prophylactic cranial irradiation combined with IT-MTX, and all of them have been alive without CNS relapse for 2 to 4 2/3 years after therapy. 3. In group A, none of 7 patients (0 %) relapsed CNS leukemia initially as compared  More>>
Authors:
Miyazaki, Toru; Konishi, Kiyosaburo; Sato, Noriko; Fujiwara, Fumihiro [1] 
  1. Maizuru National Hospital, Kyoto (Japan)
Publication Date:
Jul 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-15-052949; EDB-84-151015
Resource Relation:
Journal Name: Iryo; (Japan); Journal Volume: 37:7
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CENTRAL NERVOUS SYSTEM; MYELOID LEUKEMIA; CHILDREN; RADIOTHERAPY; CHEMOTHERAPY; COMPARATIVE EVALUATIONS; GAMMA RADIATION; METHOTREXATE; PATIENTS; SURVIVAL TIME; AGE GROUPS; ANTIMETABOLITES; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; HEMIC DISEASES; IONIZING RADIATIONS; LEUKEMIA; MEDICINE; NEOPLASMS; NERVOUS SYSTEM; NUCLEAR MEDICINE; RADIATIONS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
6601885
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: IRYOA
Submitting Site:
HEDB
Size:
Pages: 654-661
Announcement Date:

Journal Article:

Citation Formats

Miyazaki, Toru, Konishi, Kiyosaburo, Sato, Noriko, and Fujiwara, Fumihiro. Radiotherapy for leukemia in children, (1). Radiotherapy for central nervous system leukemia. Japan: N. p., 1983. Web.
Miyazaki, Toru, Konishi, Kiyosaburo, Sato, Noriko, & Fujiwara, Fumihiro. Radiotherapy for leukemia in children, (1). Radiotherapy for central nervous system leukemia. Japan.
Miyazaki, Toru, Konishi, Kiyosaburo, Sato, Noriko, and Fujiwara, Fumihiro. 1983. "Radiotherapy for leukemia in children, (1). Radiotherapy for central nervous system leukemia." Japan.
@misc{etde_6601885,
title = {Radiotherapy for leukemia in children, (1). Radiotherapy for central nervous system leukemia}
author = {Miyazaki, Toru, Konishi, Kiyosaburo, Sato, Noriko, and Fujiwara, Fumihiro}
abstractNote = {Following the development of effective chemotherapy for producing remissions of acute lymphocytic leukemia (ALL), a new phenomenon has emerged in this disease--central nervous system (CNS) leukemia. CNS leukemia has become an increasingly frequent obstacle to prolongation of initial complete remission. Prophylactic irradiation of the CNS concomitant with intrathecal administration of methotrexate (IT-MTX) has proved to be effective in the reduction of CNS involvement. The purpose of this paper is to describe the results of irradiation for prevention of CNS leukemia and to discuss their implications. The patients consisted of 32 children with acute leukemia, admitted to MAIZURU National Hospital from 1966 to 1980; 22 patients of them had ALL, the others ANLL (acute non-lymphocytic leukemia). Preventive CNS therapy was started in 1974, (group A), but there was no prevention before 1974 (group B). 1. In group B, six patients was treated by therapeutic cranial irradiation, but all cases resulted in death. 2. In group A, seven patients was treated by prophylactic cranial irradiation combined with IT-MTX, and all of them have been alive without CNS relapse for 2 to 4 2/3 years after therapy. 3. In group A, none of 7 patients (0 %) relapsed CNS leukemia initially as compared to 7 (50 %) of 14 in group B, thus preventive efficacy was clear. 4. There were no severe complications attributable to the radiotherapy, with or without IT-MTX.}
journal = {Iryo; (Japan)}
volume = {37:7}
journal type = {AC}
place = {Japan}
year = {1983}
month = {Jul}
}