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Molecular theory for nuclear magnetic relaxation in protein solutions and tissue; Surface diffusion and free-volume analogy

Conference:

Abstract

A model theory is presented explaining a series of striking phenomena observed with nuclear magnetic relaxation in protein systems such as solutions or tissue. The frequency, concentration and temperature dependences of proton or deuteron relaxation times of protein solutions and tissue are explained. It is concluded that the translational diffusion of water molecules along the rugged surfaces of proteins and, to a minor degree, protein backbone fluctuations are crucial processes. The rate limiting factor of macromolecular tumbling is assumed to be given by the free water content in a certain analogy to the free-volume model of Cohen ad Turnbull. There are two characteristic water mass fractions indicating the saturation of the hydration shells and the onset of protein tumbling. A closed and relatively simple set of relaxation formulas is presented. The potentially fractal nature of the diffusion of water molecules on the protein surface is discussed. (author). 43 refs.; 4 figs.
Authors:
Kimmich, R; Nusser, W; Gneiting, T [1] 
  1. Ulm Universitaet (Federal Republic of Germany). Sektion Kernresonanzspektroskopie
Publication Date:
Apr 01, 1990
Product Type:
Conference
Report Number:
CONF-890822-
Reference Number:
AIX-21-073204; EDB-90-144100
Resource Relation:
Journal Name: Colloids and Surfaces; (Netherlands); Journal Volume: 45; Conference: 5. international symposium on magnetic resonance in colloid and interface science, Newark, DE (USA), 7-11 Aug 1989
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; NUCLEAR MAGNETIC RESONANCE; MOLECULAR MODELS; PROTEINS; TISSUES; DIFFUSION; SPIN-LATTICE RELAXATION; TEMPERATURE DEPENDENCE; WATER; BODY; HYDROGEN COMPOUNDS; MAGNETIC RESONANCE; MATHEMATICAL MODELS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; RELAXATION; RESONANCE; 656002* - Condensed Matter Physics- General Techniques in Condensed Matter- (1987-)
OSTI ID:
6593953
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0166-6622; CODEN: COSUD
Submitting Site:
NLN
Size:
Pages: 45
Announcement Date:

Conference:

Citation Formats

Kimmich, R, Nusser, W, and Gneiting, T. Molecular theory for nuclear magnetic relaxation in protein solutions and tissue; Surface diffusion and free-volume analogy. Netherlands: N. p., 1990. Web.
Kimmich, R, Nusser, W, & Gneiting, T. Molecular theory for nuclear magnetic relaxation in protein solutions and tissue; Surface diffusion and free-volume analogy. Netherlands.
Kimmich, R, Nusser, W, and Gneiting, T. 1990. "Molecular theory for nuclear magnetic relaxation in protein solutions and tissue; Surface diffusion and free-volume analogy." Netherlands.
@misc{etde_6593953,
title = {Molecular theory for nuclear magnetic relaxation in protein solutions and tissue; Surface diffusion and free-volume analogy}
author = {Kimmich, R, Nusser, W, and Gneiting, T}
abstractNote = {A model theory is presented explaining a series of striking phenomena observed with nuclear magnetic relaxation in protein systems such as solutions or tissue. The frequency, concentration and temperature dependences of proton or deuteron relaxation times of protein solutions and tissue are explained. It is concluded that the translational diffusion of water molecules along the rugged surfaces of proteins and, to a minor degree, protein backbone fluctuations are crucial processes. The rate limiting factor of macromolecular tumbling is assumed to be given by the free water content in a certain analogy to the free-volume model of Cohen ad Turnbull. There are two characteristic water mass fractions indicating the saturation of the hydration shells and the onset of protein tumbling. A closed and relatively simple set of relaxation formulas is presented. The potentially fractal nature of the diffusion of water molecules on the protein surface is discussed. (author). 43 refs.; 4 figs.}
journal = {Colloids and Surfaces; (Netherlands)}
volume = {45}
place = {Netherlands}
year = {1990}
month = {Apr}
}