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Chronic copper poisoning. III. Effects of copper acetate injected into the bloodstream of sheep

Journal Article:

Abstract

A study was made of the clinical and biochemical effects of injections of copper (as acetate) into the bloodstream of sheep of 100 to 130 lb. liveweight. Copper in a dose of 160 mg. caused death in 3 sheep in a few hours, and 80 mg. caused death in 3 out of 4 sheep, 2 after 2 days and 1 after 11 days. Symptoms, biochemical lesions and post-mortem appearances did not resemble those of chronic copper poisoning, but rather those of gastro-enteritis. Blood glutathione concentrations were not markedly reduced, but haemoconcentration was a prominent feature. Post-mortem examination showed gross congestion of blood vessels and marked inflammatory reactions in the abomasum and small intestine. Single injections of smaller amounts (25 to 40 mg. copper) were tolerated without effect, but repeated injections, twice daily for 2 to 3 days, caused haemolytic episodes in 3 sheep similar to the crisis of chronic copper poisoning in that a marked reduction in blood glutathione concentration and accumulation of methaemoglobin occurred. No other clinical effects were produced, however, and all three animals recovered uneventfully.
Publication Date:
Jan 01, 1964
Product Type:
Journal Article
Reference Number:
EDB-84-151528
Resource Relation:
Journal Name: J. Comp. Pathol.; (United Kingdom); Journal Volume: 74:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD; HEMOLYSIS; PATHOLOGICAL CHANGES; COPPER; CHRONIC EXPOSURE; TOXICITY; SHEEP; DEATH; SENSITIVITY; ACETATES; DOSE-RESPONSE RELATIONSHIPS; INTRAVENOUS INJECTION; ANIMALS; BIOLOGICAL MATERIALS; BODY FLUIDS; CARBOXYLIC ACID SALTS; DOMESTIC ANIMALS; ELEMENTS; INJECTION; INTAKE; LYSIS; MAMMALS; MATERIALS; METALS; RUMINANTS; TRANSITION ELEMENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
6593711
Research Organizations:
The Farm, Belfast, Ireland
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JCVPA
Submitting Site:
HEDB
Size:
Pages: 542-551
Announcement Date:
Sep 01, 1984

Journal Article:

Citation Formats

Todd, J R, and Thompson, R H. Chronic copper poisoning. III. Effects of copper acetate injected into the bloodstream of sheep. United Kingdom: N. p., 1964. Web.
Todd, J R, & Thompson, R H. Chronic copper poisoning. III. Effects of copper acetate injected into the bloodstream of sheep. United Kingdom.
Todd, J R, and Thompson, R H. 1964. "Chronic copper poisoning. III. Effects of copper acetate injected into the bloodstream of sheep." United Kingdom.
@misc{etde_6593711,
title = {Chronic copper poisoning. III. Effects of copper acetate injected into the bloodstream of sheep}
author = {Todd, J R, and Thompson, R H}
abstractNote = {A study was made of the clinical and biochemical effects of injections of copper (as acetate) into the bloodstream of sheep of 100 to 130 lb. liveweight. Copper in a dose of 160 mg. caused death in 3 sheep in a few hours, and 80 mg. caused death in 3 out of 4 sheep, 2 after 2 days and 1 after 11 days. Symptoms, biochemical lesions and post-mortem appearances did not resemble those of chronic copper poisoning, but rather those of gastro-enteritis. Blood glutathione concentrations were not markedly reduced, but haemoconcentration was a prominent feature. Post-mortem examination showed gross congestion of blood vessels and marked inflammatory reactions in the abomasum and small intestine. Single injections of smaller amounts (25 to 40 mg. copper) were tolerated without effect, but repeated injections, twice daily for 2 to 3 days, caused haemolytic episodes in 3 sheep similar to the crisis of chronic copper poisoning in that a marked reduction in blood glutathione concentration and accumulation of methaemoglobin occurred. No other clinical effects were produced, however, and all three animals recovered uneventfully.}
journal = {J. Comp. Pathol.; (United Kingdom)}
volume = {74:4}
journal type = {AC}
place = {United Kingdom}
year = {1964}
month = {Jan}
}