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Serum lysozyme determinations, April-June 1961

Technical Report:

Abstract

Serum lysozyme levels were determined on 670 consecutive subjects seen for regularly scheduled clinic examinations of the Adult Health Study in Hiroshima. Serum lysozyme levels were found to vary significantly with the absolute peripheral granulocyte count, age, sex, and month of study. A high level of correlation also was noted between serum lysozyme and diabetes mellitus. This was at least in part attributable to greater average age in patients with diabetes. Suggestive relationship was established between serum lysozyme levels, respiratory diseases, and tuberculosis. These changes are believed to reflect active inflammation with excessive destruction of granulocytes and parenchymal tissues in those patients with the more acute processes. No relationship was found between serum lysozyme and previous exposure to ionizing radiation. These studies indicate that the serum lysozyme level may be useful in the study of the kinetics of leukopoiesis, the aging process, and in the detection of subtle inflammatory processes. 21 references, 5 tables.
Publication Date:
Apr 18, 1963
Product Type:
Technical Report
Report Number:
ABCC-05-63
Reference Number:
EDB-84-150481
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; BLOOD SERUM; LYSOZYME; VARIATIONS; CORRELATIONS; DIABETES MELLITUS; INFLAMMATION; QUANTITY RATIO; DISEASES; ENDOCRINE DISEASES; ENZYMES; GLYCOSYL HYDROLASES; HUMAN POPULATIONS; HYDROLASES; METABOLIC DISEASES; O-GLYCOSYL HYDROLASES; PATHOLOGICAL CHANGES; POPULATIONS; SYMPTOMS; 550200* - Biochemistry; 560151 - Radiation Effects on Animals- Man
OSTI ID:
6584263
Research Organizations:
Atomic Bomb Casualty Commission, Hiroshima (Japan); Atomic Bomb Casualty Commission, Nagasaki (Japan)
Country of Origin:
Japan
Language:
English and Japanese
Contract Number:
AC01-76EV03081
Other Identifying Numbers:
Other: ON: DE84008149
Availability:
NTIS, PC A02/MF A01.
Submitting Site:
HEDB
Size:
Pages: 18
Announcement Date:
Sep 01, 1984

Technical Report:

Citation Formats

Finch, S C, Lamphere, J P, and Jablon, S. Serum lysozyme determinations, April-June 1961. Japan: N. p., 1963. Web.
Finch, S C, Lamphere, J P, & Jablon, S. Serum lysozyme determinations, April-June 1961. Japan.
Finch, S C, Lamphere, J P, and Jablon, S. 1963. "Serum lysozyme determinations, April-June 1961." Japan.
@misc{etde_6584263,
title = {Serum lysozyme determinations, April-June 1961}
author = {Finch, S C, Lamphere, J P, and Jablon, S}
abstractNote = {Serum lysozyme levels were determined on 670 consecutive subjects seen for regularly scheduled clinic examinations of the Adult Health Study in Hiroshima. Serum lysozyme levels were found to vary significantly with the absolute peripheral granulocyte count, age, sex, and month of study. A high level of correlation also was noted between serum lysozyme and diabetes mellitus. This was at least in part attributable to greater average age in patients with diabetes. Suggestive relationship was established between serum lysozyme levels, respiratory diseases, and tuberculosis. These changes are believed to reflect active inflammation with excessive destruction of granulocytes and parenchymal tissues in those patients with the more acute processes. No relationship was found between serum lysozyme and previous exposure to ionizing radiation. These studies indicate that the serum lysozyme level may be useful in the study of the kinetics of leukopoiesis, the aging process, and in the detection of subtle inflammatory processes. 21 references, 5 tables.}
place = {Japan}
year = {1963}
month = {Apr}
}