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Platelet half-life in patients with primary hyperlipoproteinemia type IIa, IIb, and IV according to Fredrickson with and without clinical signs of atherosclerosis

Abstract

It is generally accepted that platelet half-life is shortened in atherosclerotic vascular diseases. Concerning changes due to hyperlipoproteinemia (HLP), however, there exist only few data. Therefore, we examined the platelet-half life in 60 patients with recently discovered HLP type IIa, IIb and IV according to Fredrickson before treatment in comparison to 60 controls. 33 of the HLP-patients had no clinical symptoms of angiopathy. 27 patients suffered from peripheral vascular disease or from coronary heart disease as verified by angiography. The labelling of autologous platelets was performed with 100..mu..Ci of /sup 111/Indium-oxine-sulfate at 37/sup 0/C for 5 minutes. The mean labelling efficiency was 90%, the recovery after 2 hours about 70%. Serum lipoproteins were estimated by means of ultracentrifugation and polyanionprecipitation according to Lipid Research Clinic Methods. In the patients with HLP platelet half-life was significantly shortened in comparison to the control group (p < 0.01). These changes were most pronounced in patients with HLP-type IIa and with atherosclerotic lesions, respectively. In patients with HLP-type IIa a very close correlation could be demonstrated between platelet half-life and LDL-cholesterol (r = -0.72; p < 0.001) as well as total cholesterol (r = -0.73; p < 0.001). These data prove that in HLP  More>>
Publication Date:
Sep 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-717340; EDB-83-036672
Resource Relation:
Journal Name: Wien. Klin. Wochenschr.; (Austria); Journal Volume: 94:16
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIOSCLEROSIS; DIAGNOSIS; BLOOD PLATELETS; BIOLOGICAL HALF-LIFE; LABELLING; INDIUM 111; DIAGNOSTIC USES; LIPOPROTEINS; CARDIOVASCULAR DISEASES; CHOLESTEROL; GAMMA CAMERAS; HALF-LIFE; HEREDITARY DISEASES; METABOLIC DISEASES; PATIENTS; RADIATION DOSES; RADIOPHARMACEUTICALS; SYMPTOMS; TRACER TECHNIQUES; TRIGLYCERIDES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CAMERAS; DAYS LIVING RADIOISOTOPES; DISEASES; DOSES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ESTERS; HYDROXY COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIPIDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; STEROIDS; STEROLS; USES; VASCULAR DISEASES; 550901* - Pathology- Tracer Techniques; 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 550301 - Cytology- Tracer Techniques
OSTI ID:
6580452
Country of Origin:
Austria
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: WKWOA
Submitting Site:
HEDB
Size:
Pages: 421-425
Announcement Date:
Jan 01, 1983

Citation Formats

Jaeger, E, Sinzinger, H, Widhalm, K, Kaliman, J, Hoefer, R, Ludwig Boltzmann-Institut fuer Nuklearmedizin, Vienna (Austria), Vienna Univ. (Austria). Kinderklinik, and Vienna Univ. (Austria). Kardiologische Klinik). Platelet half-life in patients with primary hyperlipoproteinemia type IIa, IIb, and IV according to Fredrickson with and without clinical signs of atherosclerosis. Austria: N. p., 1982. Web.
Jaeger, E, Sinzinger, H, Widhalm, K, Kaliman, J, Hoefer, R, Ludwig Boltzmann-Institut fuer Nuklearmedizin, Vienna (Austria), Vienna Univ. (Austria). Kinderklinik, &amp; Vienna Univ. (Austria). Kardiologische Klinik). Platelet half-life in patients with primary hyperlipoproteinemia type IIa, IIb, and IV according to Fredrickson with and without clinical signs of atherosclerosis. Austria.
Jaeger, E, Sinzinger, H, Widhalm, K, Kaliman, J, Hoefer, R, Ludwig Boltzmann-Institut fuer Nuklearmedizin, Vienna (Austria), Vienna Univ. (Austria). Kinderklinik, and Vienna Univ. (Austria). Kardiologische Klinik). 1982. "Platelet half-life in patients with primary hyperlipoproteinemia type IIa, IIb, and IV according to Fredrickson with and without clinical signs of atherosclerosis." Austria.
@misc{etde_6580452,
title = {Platelet half-life in patients with primary hyperlipoproteinemia type IIa, IIb, and IV according to Fredrickson with and without clinical signs of atherosclerosis}
author = {Jaeger, E, Sinzinger, H, Widhalm, K, Kaliman, J, Hoefer, R, Ludwig Boltzmann-Institut fuer Nuklearmedizin, Vienna (Austria), Vienna Univ. (Austria). Kinderklinik, and Vienna Univ. (Austria). Kardiologische Klinik)}
abstractNote = {It is generally accepted that platelet half-life is shortened in atherosclerotic vascular diseases. Concerning changes due to hyperlipoproteinemia (HLP), however, there exist only few data. Therefore, we examined the platelet-half life in 60 patients with recently discovered HLP type IIa, IIb and IV according to Fredrickson before treatment in comparison to 60 controls. 33 of the HLP-patients had no clinical symptoms of angiopathy. 27 patients suffered from peripheral vascular disease or from coronary heart disease as verified by angiography. The labelling of autologous platelets was performed with 100..mu..Ci of /sup 111/Indium-oxine-sulfate at 37/sup 0/C for 5 minutes. The mean labelling efficiency was 90%, the recovery after 2 hours about 70%. Serum lipoproteins were estimated by means of ultracentrifugation and polyanionprecipitation according to Lipid Research Clinic Methods. In the patients with HLP platelet half-life was significantly shortened in comparison to the control group (p < 0.01). These changes were most pronounced in patients with HLP-type IIa and with atherosclerotic lesions, respectively. In patients with HLP-type IIa a very close correlation could be demonstrated between platelet half-life and LDL-cholesterol (r = -0.72; p < 0.001) as well as total cholesterol (r = -0.73; p < 0.001). These data prove that in HLP in-vivo platelet function as measured by platelet survival is significantly influenced even before the occurrence of clinically relevant symptoms of atherosclerosis.}
journal = []
volume = {94:16}
journal type = {AC}
place = {Austria}
year = {1982}
month = {Sep}
}