Abstract
Radiotherapy in cervical carcinoma patients is frequently followed by severe intestinal injuries which serve as prerequisites for the penetration of endotoxins of intestinal microflora into the systemic circulation. Peculiarities of possible development of endotoxemia were studied in 45 women with cervical carcinoma (Stages 2, 3). Radiotherapy was performed by routine methods (long-focus irradiation with subsequent intracavitary irradiation, or simultaneous long-focus and intracavitary irradiation). The presence of bacterial endotoxins in the patients blood was revealed by the testing of the lethal effect after intraperitoneal administration of the examined blood (0.1 ml) to random-bred albino mice simultaneously with actinomycin D(10 ..mu..g/mouse) that sharply increases the sensitivity of animals to a toxic effect of endotoxins. It has been established that involvement of the intestine in irradiation is followed by endotoxemia regardless of radiotherapeutic methods. The degree of severity of endotoxemia developing in the first half of a radiotherapeutic course depends on a radiation dose. On reaching a certain level, endotoxemia preserves its severity up to the end of irradiation and at early time after its completion.
Gabelov, A A;
Kiselev, P N;
Shul's, T S
[1]
- Tsentral'nyj Nauchno-Issledovatel'skij Rentgeno-Radiologicheskij Inst., Leningrad (USSR)
Citation Formats
Gabelov, A A, Kiselev, P N, and Shul's, T S.
Peculiarities of endotoxemia during radiotherapy of cervical carcinoma.
USSR: N. p.,
1981.
Web.
Gabelov, A A, Kiselev, P N, & Shul's, T S.
Peculiarities of endotoxemia during radiotherapy of cervical carcinoma.
USSR.
Gabelov, A A, Kiselev, P N, and Shul's, T S.
1981.
"Peculiarities of endotoxemia during radiotherapy of cervical carcinoma."
USSR.
@misc{etde_6579682,
title = {Peculiarities of endotoxemia during radiotherapy of cervical carcinoma}
author = {Gabelov, A A, Kiselev, P N, and Shul's, T S}
abstractNote = {Radiotherapy in cervical carcinoma patients is frequently followed by severe intestinal injuries which serve as prerequisites for the penetration of endotoxins of intestinal microflora into the systemic circulation. Peculiarities of possible development of endotoxemia were studied in 45 women with cervical carcinoma (Stages 2, 3). Radiotherapy was performed by routine methods (long-focus irradiation with subsequent intracavitary irradiation, or simultaneous long-focus and intracavitary irradiation). The presence of bacterial endotoxins in the patients blood was revealed by the testing of the lethal effect after intraperitoneal administration of the examined blood (0.1 ml) to random-bred albino mice simultaneously with actinomycin D(10 ..mu..g/mouse) that sharply increases the sensitivity of animals to a toxic effect of endotoxins. It has been established that involvement of the intestine in irradiation is followed by endotoxemia regardless of radiotherapeutic methods. The degree of severity of endotoxemia developing in the first half of a radiotherapeutic course depends on a radiation dose. On reaching a certain level, endotoxemia preserves its severity up to the end of irradiation and at early time after its completion.}
journal = []
volume = {26:11}
journal type = {AC}
place = {USSR}
year = {1981}
month = {Nov}
}
title = {Peculiarities of endotoxemia during radiotherapy of cervical carcinoma}
author = {Gabelov, A A, Kiselev, P N, and Shul's, T S}
abstractNote = {Radiotherapy in cervical carcinoma patients is frequently followed by severe intestinal injuries which serve as prerequisites for the penetration of endotoxins of intestinal microflora into the systemic circulation. Peculiarities of possible development of endotoxemia were studied in 45 women with cervical carcinoma (Stages 2, 3). Radiotherapy was performed by routine methods (long-focus irradiation with subsequent intracavitary irradiation, or simultaneous long-focus and intracavitary irradiation). The presence of bacterial endotoxins in the patients blood was revealed by the testing of the lethal effect after intraperitoneal administration of the examined blood (0.1 ml) to random-bred albino mice simultaneously with actinomycin D(10 ..mu..g/mouse) that sharply increases the sensitivity of animals to a toxic effect of endotoxins. It has been established that involvement of the intestine in irradiation is followed by endotoxemia regardless of radiotherapeutic methods. The degree of severity of endotoxemia developing in the first half of a radiotherapeutic course depends on a radiation dose. On reaching a certain level, endotoxemia preserves its severity up to the end of irradiation and at early time after its completion.}
journal = []
volume = {26:11}
journal type = {AC}
place = {USSR}
year = {1981}
month = {Nov}
}