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Effect of superficial radial nerve stimulation on the activity of nigro-striatal dopaminergic neurons in the cat: role of cutaneous sensory input

Abstract

The release of /sup 3/H-dopamine (DA) continuously synthesized from /sup 3/H-thyrosine was measured in the caudate nucleus (CN) and in the substantia nigra (SN) in both sides of the brain during electrical stimulation of the superficial radial nerve in cats lightly anaesthetized with halothane. Use of appropriate electrophysiologically controlled stimulation led to selective activation of low threshold afferent fibers whereas high stimulation activated all cutaneous afferents. Results showed that low threshold fiber activation induced a decreased dopaminergic activity in CN contralateral to nerve stimulation and a concomitant increase in dopaminergic activity on the ipsilateral side. Stimulation of group I and threshold stimulation of group II afferent fibers induced changes in the release of /sup 3/H-DA mainly on the contralateral CN and SN and in the ipsilateral CN. High stimulation was followed by a general increase of the neurotransmitter release in the four structures. This shows that the nigro-striatal dopaminergic neurons are mainly-if not exclusively-controlled by cutaneous sensory inputs. This control, non-specific when high threshold cutaneous fibers are also activated. Such activations could contribute to reestablish sufficient release of DA when the dopaminergic function is impaired as in Parkinson's disease.
Authors:
Nieoullon, A; Dusticier, N [1] 
  1. Centre National de la Recherche Scientifique, 13 - Marseille (France). Inst. de Neurophysiologie et Psychophysiologie
Publication Date:
Jan 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-710803; EDB-83-036704
Resource Relation:
Journal Name: J. Neural Transm.; (Austria); Journal Volume: 53:2-3
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; STIMULATION; DOPAMINE; BIOSYNTHESIS; CATS; LABELLED COMPOUNDS; METABOLITES; NERVES; ORGANIC ION EXCHANGERS; QUANTITY RATIO; REFLEXES; TRITIUM; UPTAKE; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DRUGS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ION EXCHANGE MATERIALS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 551001* - Physiological Systems- Tracer Techniques
OSTI ID:
6578482
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JNTMA
Submitting Site:
HEDB
Size:
Pages: 133-146
Announcement Date:

Citation Formats

Nieoullon, A, and Dusticier, N. Effect of superficial radial nerve stimulation on the activity of nigro-striatal dopaminergic neurons in the cat: role of cutaneous sensory input. Austria: N. p., 1982. Web. doi:10.1007/BF01243405.
Nieoullon, A, & Dusticier, N. Effect of superficial radial nerve stimulation on the activity of nigro-striatal dopaminergic neurons in the cat: role of cutaneous sensory input. Austria. doi:10.1007/BF01243405.
Nieoullon, A, and Dusticier, N. 1982. "Effect of superficial radial nerve stimulation on the activity of nigro-striatal dopaminergic neurons in the cat: role of cutaneous sensory input." Austria. doi:10.1007/BF01243405. https://www.osti.gov/servlets/purl/10.1007/BF01243405.
@misc{etde_6578482,
title = {Effect of superficial radial nerve stimulation on the activity of nigro-striatal dopaminergic neurons in the cat: role of cutaneous sensory input}
author = {Nieoullon, A, and Dusticier, N}
abstractNote = {The release of /sup 3/H-dopamine (DA) continuously synthesized from /sup 3/H-thyrosine was measured in the caudate nucleus (CN) and in the substantia nigra (SN) in both sides of the brain during electrical stimulation of the superficial radial nerve in cats lightly anaesthetized with halothane. Use of appropriate electrophysiologically controlled stimulation led to selective activation of low threshold afferent fibers whereas high stimulation activated all cutaneous afferents. Results showed that low threshold fiber activation induced a decreased dopaminergic activity in CN contralateral to nerve stimulation and a concomitant increase in dopaminergic activity on the ipsilateral side. Stimulation of group I and threshold stimulation of group II afferent fibers induced changes in the release of /sup 3/H-DA mainly on the contralateral CN and SN and in the ipsilateral CN. High stimulation was followed by a general increase of the neurotransmitter release in the four structures. This shows that the nigro-striatal dopaminergic neurons are mainly-if not exclusively-controlled by cutaneous sensory inputs. This control, non-specific when high threshold cutaneous fibers are also activated. Such activations could contribute to reestablish sufficient release of DA when the dopaminergic function is impaired as in Parkinson's disease.}
doi = {10.1007/BF01243405}
journal = {J. Neural Transm.; (Austria)}
volume = {53:2-3}
journal type = {AC}
place = {Austria}
year = {1982}
month = {Jan}
}