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Gastric cancer in coal miners: an hypothesis of coal mine dust causation

Abstract

An hypothesis is proposed to explain the elevated incidence of gastric cancer among coal miners. Inhaled coal mine dust, especially the larger particles, is cleared from the lung and tracheobronchial tree by mucociliary function, swallowed, and introduced into the stomach. Organic and/or inorganic materials in the dust can undergo intra-gastric nitrosation and/or interaction with exogenous chemicals to form carcinogenic compounds which in turn may lead to precancerous lesions, which may subsequently develop into gastric cancer. This sequence of events, however, depends upon occupational exposures as well as life-style features and individual genetic predisposition.
Publication Date:
Oct 01, 1983
Product Type:
Journal Article
Reference Number:
EDB-84-155222
Resource Relation:
Journal Name: Med. Hypotheses; (United Kingdom); Journal Volume: 12:2
Subject:
01 COAL, LIGNITE, AND PEAT; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; COAL MINERS; HEALTH HAZARDS; NEOPLASMS; ETIOLOGY; CARCINOGENESIS; COAL; DUSTS; GENETIC VARIABILITY; INGESTION; INHALATION; LIFE STYLES; OCCUPATIONAL EXPOSURE; STOMACH; BIOLOGICAL VARIABILITY; BODY; CARBONACEOUS MATERIALS; DIGESTIVE SYSTEM; DISEASES; ENERGY SOURCES; FOSSIL FUELS; FUELS; GASTROINTESTINAL TRACT; HAZARDS; INTAKE; MATERIALS; MINERS; ORGANS; PATHOGENESIS; PERSONNEL; 016000* - Coal, Lignite, & Peat- Health & Safety; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
6573530
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MEHYD
Submitting Site:
HEDB
Size:
Pages: 159-165
Announcement Date:

Citation Formats

Ong, T M, Whong, W Z, and Ames, R G. Gastric cancer in coal miners: an hypothesis of coal mine dust causation. United Kingdom: N. p., 1983. Web. doi:10.1016/0306-9877(83)90077-4.
Ong, T M, Whong, W Z, & Ames, R G. Gastric cancer in coal miners: an hypothesis of coal mine dust causation. United Kingdom. doi:10.1016/0306-9877(83)90077-4.
Ong, T M, Whong, W Z, and Ames, R G. 1983. "Gastric cancer in coal miners: an hypothesis of coal mine dust causation." United Kingdom. doi:10.1016/0306-9877(83)90077-4. https://www.osti.gov/servlets/purl/10.1016/0306-9877(83)90077-4.
@misc{etde_6573530,
title = {Gastric cancer in coal miners: an hypothesis of coal mine dust causation}
author = {Ong, T M, Whong, W Z, and Ames, R G}
abstractNote = {An hypothesis is proposed to explain the elevated incidence of gastric cancer among coal miners. Inhaled coal mine dust, especially the larger particles, is cleared from the lung and tracheobronchial tree by mucociliary function, swallowed, and introduced into the stomach. Organic and/or inorganic materials in the dust can undergo intra-gastric nitrosation and/or interaction with exogenous chemicals to form carcinogenic compounds which in turn may lead to precancerous lesions, which may subsequently develop into gastric cancer. This sequence of events, however, depends upon occupational exposures as well as life-style features and individual genetic predisposition.}
doi = {10.1016/0306-9877(83)90077-4}
journal = {Med. Hypotheses; (United Kingdom)}
volume = {12:2}
journal type = {AC}
place = {United Kingdom}
year = {1983}
month = {Oct}
}