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Effects of cadmium on chick embryogenesis and some comparisons with lead

Journal Article:

Abstract

During the last ten years because of the severity of the problem of pollution and the part that heavy metals play in it we have been doing research on the effects of some heavy metals on chick embryogenesis in order to get a comparative study and to elucidate their mechanisms of action. Experiments were performed using 431 fertilized white Leghorn eggs to study the effect of cadmium on chick embryogenesis. Cadmium acetate at 0.015, 0.030, 0.045, 0.060, 0.12 or 0.24 mg/egg and lead acetate at 0.02, 0.04 or 0.075 mg/egg was injected in ovo on the fourth day of incubation. The embryos were taken out on the 19th day and examined for gross defects. Electrocardiograms were recorded on some embryos. Hemoglobin determinations were done on others. The changes in plasma delta-aminolevulinic acid dehydrase (ALAD) of the embryos due to cadmium and lead acetate were also determined. It was found that the LD50 of cadmium acetate was close to 0.045 mg. The highest incidence of abnormality, 30.9% of the surviving embryos, appeared in the 0.030 mg group although malformed embryos were also found in the 0.015, 0.045 and 0.060 mg groups. The most common malformations occurred in the liver (58%) and  More>>
Publication Date:
Jul 01, 1978
Product Type:
Journal Article
Reference Number:
ERA-04-011590; EDB-79-014684
Resource Relation:
Journal Name: Proc. Natl. Sci. Counc., Repub. China; (Taiwan); Journal Volume: 2:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; BIOLOGICAL EFFECTS; COMPARATIVE EVALUATIONS; EMBRYOS; MALFORMATIONS; LEAD; ONTOGENESIS; CHICKENS; ELECTROCARDIOGRAMS; ENZYMES; HEMOGLOBIN; ANIMALS; BIRDS; CARBOXYLIC ACIDS; DIAGRAMS; DISEASES; ELEMENTS; FOWL; GLOBIN; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; METALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOLOGICAL CHANGES; PIGMENTS; PORPHYRINS; PROTEINS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
6571757
Research Organizations:
National Taiwan Univ., Taipei
Country of Origin:
Taiwan, Province of China
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PSIAD
Submitting Site:
TIC
Size:
Pages: 269-274
Announcement Date:
Jan 01, 1979

Journal Article:

Citation Formats

King, D W, Chen, D C.C., and Hsu, J L. Effects of cadmium on chick embryogenesis and some comparisons with lead. Taiwan, Province of China: N. p., 1978. Web.
King, D W, Chen, D C.C., & Hsu, J L. Effects of cadmium on chick embryogenesis and some comparisons with lead. Taiwan, Province of China.
King, D W, Chen, D C.C., and Hsu, J L. 1978. "Effects of cadmium on chick embryogenesis and some comparisons with lead." Taiwan, Province of China.
@misc{etde_6571757,
title = {Effects of cadmium on chick embryogenesis and some comparisons with lead}
author = {King, D W, Chen, D C.C., and Hsu, J L}
abstractNote = {During the last ten years because of the severity of the problem of pollution and the part that heavy metals play in it we have been doing research on the effects of some heavy metals on chick embryogenesis in order to get a comparative study and to elucidate their mechanisms of action. Experiments were performed using 431 fertilized white Leghorn eggs to study the effect of cadmium on chick embryogenesis. Cadmium acetate at 0.015, 0.030, 0.045, 0.060, 0.12 or 0.24 mg/egg and lead acetate at 0.02, 0.04 or 0.075 mg/egg was injected in ovo on the fourth day of incubation. The embryos were taken out on the 19th day and examined for gross defects. Electrocardiograms were recorded on some embryos. Hemoglobin determinations were done on others. The changes in plasma delta-aminolevulinic acid dehydrase (ALAD) of the embryos due to cadmium and lead acetate were also determined. It was found that the LD50 of cadmium acetate was close to 0.045 mg. The highest incidence of abnormality, 30.9% of the surviving embryos, appeared in the 0.030 mg group although malformed embryos were also found in the 0.015, 0.045 and 0.060 mg groups. The most common malformations occurred in the liver (58%) and the cardiovascular system, with edema totalling over 90%. Lesser abnormalities were observed in the limbs. Lead acetate affected ALAD more than cadmium acetate. There was no significant difference on hemoglobin concentration or EKG between the distilled water control and either the cadmium or lead treated groups. Thus, embryolethality, embryotoxicity, congenital abnormalities and changes in ALAD were all observed in the cadmium-treated chick embryos although lead acetate seemed to inhibit the ALAD activity more effectively than cadmium acetate.}
journal = {Proc. Natl. Sci. Counc., Repub. China; (Taiwan)}
volume = {2:3}
journal type = {AC}
place = {Taiwan, Province of China}
year = {1978}
month = {Jul}
}