You need JavaScript to view this

Chromosome aberrations induced by radiation. With special reference to possible relation between chromosome aberrations and carcinogenesis

Journal Article:

Abstract

Chromosome aberration seems to be one of the most conspicuous residual abnormalities recognizable in radiation-exposed persons for many years after exposure. Knowledge of the biological significance of these abnormalities seems to be necessary for understanding of the effect of radiation on humans, especially in relation to possible leukemic development. Cytogenetic studies were performed on the bone marrow cells, T and B lymphocytes, and fibroblasts in atomic bomb-survivors who were in apparent good health (105 cases), atomic bomb exposed patients who had prolonged periods of blood disorders which terminated in acute leukemia (8 cases), and who had no such abnormalities (6 cases). All patients with chronic myelocytic leukemia (CML) and a history of atomic bomb exposure showed Philadelphia chromosome, a characteristic chromosome abnormality for CML. The persistent chromosome aberrations of bone marrow cells, T and B lymphocytes found among the atomic bomb survivors with or without blood disorders may give some clue to solve the problems of carcinogenesis.
Authors:
Kamada, N [1] 
  1. Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology
Publication Date:
Feb 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-601964; EDB-81-064652
Resource Relation:
Journal Name: Gan to Kagaku Ryoho; (Japan); Journal Volume: 7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; CHROMOSOMAL ABERRATIONS; DELAYED RADIATION EFFECTS; ANEMIAS; BONE MARROW CELLS; DNA; FIBROBLASTS; LEUKEMOGENESIS; LYMPHOCYTES; MYELOID LEUKEMIA; RADIATION INJURIES; RADIOINDUCTION; THYMOCYTES; TIME DEPENDENCE; ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARCINOGENESIS; CONNECTIVE TISSUE CELLS; DISEASES; HEMIC DISEASES; HUMAN POPULATIONS; INJURIES; LEUKEMIA; LEUKOCYTES; MATERIALS; MUTATIONS; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PATHOGENESIS; POPULATIONS; RADIATION EFFECTS; SOMATIC CELLS; SYMPTOMS; 560151* - Radiation Effects on Animals- Man; 560122 - Radiation Effects on Cells- Internal Source- (-1987)
OSTI ID:
6569968
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: GTKRD
Submitting Site:
INIS
Size:
Pages: 140-149
Announcement Date:

Journal Article:

Citation Formats

Kamada, N. Chromosome aberrations induced by radiation. With special reference to possible relation between chromosome aberrations and carcinogenesis. Japan: N. p., 1980. Web.
Kamada, N. Chromosome aberrations induced by radiation. With special reference to possible relation between chromosome aberrations and carcinogenesis. Japan.
Kamada, N. 1980. "Chromosome aberrations induced by radiation. With special reference to possible relation between chromosome aberrations and carcinogenesis." Japan.
@misc{etde_6569968,
title = {Chromosome aberrations induced by radiation. With special reference to possible relation between chromosome aberrations and carcinogenesis}
author = {Kamada, N}
abstractNote = {Chromosome aberration seems to be one of the most conspicuous residual abnormalities recognizable in radiation-exposed persons for many years after exposure. Knowledge of the biological significance of these abnormalities seems to be necessary for understanding of the effect of radiation on humans, especially in relation to possible leukemic development. Cytogenetic studies were performed on the bone marrow cells, T and B lymphocytes, and fibroblasts in atomic bomb-survivors who were in apparent good health (105 cases), atomic bomb exposed patients who had prolonged periods of blood disorders which terminated in acute leukemia (8 cases), and who had no such abnormalities (6 cases). All patients with chronic myelocytic leukemia (CML) and a history of atomic bomb exposure showed Philadelphia chromosome, a characteristic chromosome abnormality for CML. The persistent chromosome aberrations of bone marrow cells, T and B lymphocytes found among the atomic bomb survivors with or without blood disorders may give some clue to solve the problems of carcinogenesis.}
journal = {Gan to Kagaku Ryoho; (Japan)}
volume = {7}
journal type = {AC}
place = {Japan}
year = {1980}
month = {Feb}
}