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Serum immunoreactive calcitonin concentration in hepatocellular carcinoma

Journal Article:

Abstract

Having found raised serum calcitonin concentrations in 94% of patients with hepatocellular carcinoma when using a dextran-coated-charcoal radio-immunoassay, we have now repeated the study, using a double-antibody radio-immunoassay, in 102 further patients with hepatocellular carcinoma and 35 matched controls. Serum immunoreactive calcitonin concentrations (iCT) in the controls ranged from 10 to 310 pg/ml (mean 154,6 pg/ml). Values in the tumour patients ranged from 10 to 1,650 pg/ml (mean 302,6 pg/ml). The mean figures were significantly higher in the tumour patients (P smaller than 0,001), 35.5% of them having values above 310 pg/ml. In 65 of the patients serum iCT concentrations were also determined by dextran-coated-charcoal radio-immunoassay. Values ranged from 10 to 10780 pg/ml (mean 2,179 pg/ml). If 1,000 pg/ml is taken as the upper limit of normal, 69% of the patients had raised iCT concentrations. There was a good correlation (r=0,67; P smaller than 0,001) between serum iCT values measured with both methods in 50 patients. If measured by the double-antibody radio-immunoassay method, the serum calcitonin value is not useful as a marker for hepatocellular carcinoma.
Authors:
Dugard, J; Kew, M C; Da Fonseca, M; Levin, J [1] 
  1. University of the Witwatersrand, Johannesburg (South Africa)
Publication Date:
Aug 21, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-711106; EDB-83-036243
Resource Relation:
Journal Name: S.Afr. Med. J.; (South Africa); Journal Volume: 62:9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CALCITONIN; RADIOIMMUNOASSAY; LIVER; CARCINOMAS; ANTIBODIES; BLOOD SERUM; CHARCOAL; DEXTRAN; HORMONES; IMMUNE REACTIONS; IMMUNE SERUMS; IODINE 125; LABELLING; PATIENTS; ADSORBENTS; BETA DECAY RADIOISOTOPES; BLOOD SUBSTITUTES; BODY; CARBOHYDRATES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; HEMATOLOGIC AGENTS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; POLYSACCHARIDES; PROTEINS; RADIOASSAY; RADIOISOTOPES; SACCHARIDES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6568898
Country of Origin:
South Africa
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: SAMJA
Submitting Site:
HEDB
Size:
Pages: 271-273
Announcement Date:
Nov 01, 1982

Journal Article:

Citation Formats

Dugard, J, Kew, M C, Da Fonseca, M, and Levin, J. Serum immunoreactive calcitonin concentration in hepatocellular carcinoma. South Africa: N. p., 1982. Web.
Dugard, J, Kew, M C, Da Fonseca, M, & Levin, J. Serum immunoreactive calcitonin concentration in hepatocellular carcinoma. South Africa.
Dugard, J, Kew, M C, Da Fonseca, M, and Levin, J. 1982. "Serum immunoreactive calcitonin concentration in hepatocellular carcinoma." South Africa.
@misc{etde_6568898,
title = {Serum immunoreactive calcitonin concentration in hepatocellular carcinoma}
author = {Dugard, J, Kew, M C, Da Fonseca, M, and Levin, J}
abstractNote = {Having found raised serum calcitonin concentrations in 94% of patients with hepatocellular carcinoma when using a dextran-coated-charcoal radio-immunoassay, we have now repeated the study, using a double-antibody radio-immunoassay, in 102 further patients with hepatocellular carcinoma and 35 matched controls. Serum immunoreactive calcitonin concentrations (iCT) in the controls ranged from 10 to 310 pg/ml (mean 154,6 pg/ml). Values in the tumour patients ranged from 10 to 1,650 pg/ml (mean 302,6 pg/ml). The mean figures were significantly higher in the tumour patients (P smaller than 0,001), 35.5% of them having values above 310 pg/ml. In 65 of the patients serum iCT concentrations were also determined by dextran-coated-charcoal radio-immunoassay. Values ranged from 10 to 10780 pg/ml (mean 2,179 pg/ml). If 1,000 pg/ml is taken as the upper limit of normal, 69% of the patients had raised iCT concentrations. There was a good correlation (r=0,67; P smaller than 0,001) between serum iCT values measured with both methods in 50 patients. If measured by the double-antibody radio-immunoassay method, the serum calcitonin value is not useful as a marker for hepatocellular carcinoma.}
journal = {S.Afr. Med. J.; (South Africa)}
volume = {62:9}
journal type = {AC}
place = {South Africa}
year = {1982}
month = {Aug}
}