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Effects of cholecystokinin octapeptide on striatal dopamine metabolism and on apomorphine-induced stereotyped cage-climbing in mice

Journal Article:

Abstract

The effects of sulfated (CCK-8-SE) and non-sulfated (CCK-8-NS) cholecystokinin octapeptide on striatal dopamine (DA) metabolism have been investigated on mice. CCK-8-NS facilitated the disappearance of striatal DA, measured after synthesis inhibition with 350 mg/kg of ..cap alpha..-methyl-p-tyrosine. CCK-8-SE did not affect DA disappearance. In vitro uptake of (/sup 3/H)DA by striatal slices was affected by neither CCK-8-SE, nor CCK-8-NS (10/sup -5/ M). Potassium-induced in vitro release of (/sup 3/H)DA from striatal slices was significantly increased by 10/sup -5/ M CCK-8-NS: however, CCK-8-SE likewise increased DA release in this model system. Apomorphine-induced (1.0 mg/kg) stereotyped cage-climbing behavior was not affected by CCK-8-SE but was enhanced by CCK-8-NS. This effect could be antagonized by haloperidol, but not by naloxone. The data suggest that CCK-8-NS affects striatal DA release, disappearance and receptor sensitivity in the mouse. Dopaminergic mechanisms should therefore be regarded as a possible mode of action of CCK-8-NS on brain functions.
Authors:
Kovacs, G L; Szabo, G; Telegdy, G; [1]  Penke, B [2] 
  1. Institute of Pathophysiology, University Medical School, Szeged, Hungary
  2. Institute of Medical Chemistry, University Medical School, Szeged, Hungary
Publication Date:
Jan 29, 1981
Product Type:
Journal Article
Reference Number:
AIX-12-599543; EDB-81-052651
Resource Relation:
Journal Name: Eur. J. Pharmacol.; (Netherlands); Journal Volume: 69:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DOPAMINE; METABOLISM; POLYPEPTIDES; BIOLOGICAL EFFECTS; BRAIN; KININS; LABELLED COMPOUNDS; MICE; RADIONUCLIDE KINETICS; TRITIUM; UPTAKE; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DRUGS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDES; PHENOLS; POLYPHENOLS; PROTEINS; RADIOISOTOPES; RODENTS; SYMPATHOMIMETICS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
OSTI ID:
6564139
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJPHA
Submitting Site:
INIS
Size:
Pages: 313-319
Announcement Date:

Journal Article:

Citation Formats

Kovacs, G L, Szabo, G, Telegdy, G, and Penke, B. Effects of cholecystokinin octapeptide on striatal dopamine metabolism and on apomorphine-induced stereotyped cage-climbing in mice. Netherlands: N. p., 1981. Web.
Kovacs, G L, Szabo, G, Telegdy, G, & Penke, B. Effects of cholecystokinin octapeptide on striatal dopamine metabolism and on apomorphine-induced stereotyped cage-climbing in mice. Netherlands.
Kovacs, G L, Szabo, G, Telegdy, G, and Penke, B. 1981. "Effects of cholecystokinin octapeptide on striatal dopamine metabolism and on apomorphine-induced stereotyped cage-climbing in mice." Netherlands.
@misc{etde_6564139,
title = {Effects of cholecystokinin octapeptide on striatal dopamine metabolism and on apomorphine-induced stereotyped cage-climbing in mice}
author = {Kovacs, G L, Szabo, G, Telegdy, G, and Penke, B}
abstractNote = {The effects of sulfated (CCK-8-SE) and non-sulfated (CCK-8-NS) cholecystokinin octapeptide on striatal dopamine (DA) metabolism have been investigated on mice. CCK-8-NS facilitated the disappearance of striatal DA, measured after synthesis inhibition with 350 mg/kg of ..cap alpha..-methyl-p-tyrosine. CCK-8-SE did not affect DA disappearance. In vitro uptake of (/sup 3/H)DA by striatal slices was affected by neither CCK-8-SE, nor CCK-8-NS (10/sup -5/ M). Potassium-induced in vitro release of (/sup 3/H)DA from striatal slices was significantly increased by 10/sup -5/ M CCK-8-NS: however, CCK-8-SE likewise increased DA release in this model system. Apomorphine-induced (1.0 mg/kg) stereotyped cage-climbing behavior was not affected by CCK-8-SE but was enhanced by CCK-8-NS. This effect could be antagonized by haloperidol, but not by naloxone. The data suggest that CCK-8-NS affects striatal DA release, disappearance and receptor sensitivity in the mouse. Dopaminergic mechanisms should therefore be regarded as a possible mode of action of CCK-8-NS on brain functions.}
journal = {Eur. J. Pharmacol.; (Netherlands)}
volume = {69:3}
journal type = {AC}
place = {Netherlands}
year = {1981}
month = {Jan}
}