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Air pollutant sulfur dioxide-induced alterations on the levels of lipids, lipid peroxidation and lipase activity in various regions of the rat brain

Journal Article:

Abstract

The exposure of rats to SO/sub 2/ (10 p.p.m.) for one hour daily for 30 days caused depletion of total lipids in all brain areas. The contents of phospholipid were elevated in cerebellum and brain stem, but were depleted in cerebral hemisphere. Cholesterol levels showed an increase in various brain regions. On the other hand, gangliosides were increased in cerebellum and brain stem, but were decreased in cerebral hemisphere. Interestingly, cholesterol/phospholipid ratio was increased in different regions of the brain. Lipase activity was elevated in cerebral hemisphere. Lipid peroxidation showed marked increment in whole brain and in all the brain areas studied. The results suggest that SO/sub 2/-exposure induces degradation of lipids. Interestingly, the lipid contents are affected differentially in the various parts of the brain.
Publication Date:
Jul 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-83-036910
Resource Relation:
Journal Name: Acta Pharmacol. Toxicol.; (Denmark); Journal Volume: 51:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; METABOLISM; LIPIDS; SULFUR DIOXIDE; BIOLOGICAL EFFECTS; CEREBELLUM; CEREBRUM; CHOLESTEROL; ENZYME ACTIVITY; LIPASE; PEROXIDES; PHOSPHOLIPIDS; RATS; ANIMALS; BODY; CARBOXYLESTERASES; CENTRAL NERVOUS SYSTEM; CHALCOGENIDES; ENZYMES; ESTERASES; ESTERS; HYDROLASES; HYDROXY COMPOUNDS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; RODENTS; STEROIDS; STEROLS; SULFUR COMPOUNDS; SULFUR OXIDES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
6563147
Research Organizations:
Brain Research Center, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
Country of Origin:
Denmark
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: APTOA
Submitting Site:
HEDB
Size:
Pages: 45-50
Announcement Date:

Journal Article:

Citation Formats

Haider, S S, Hasan, M, and Khan, N H. Air pollutant sulfur dioxide-induced alterations on the levels of lipids, lipid peroxidation and lipase activity in various regions of the rat brain. Denmark: N. p., 1982. Web.
Haider, S S, Hasan, M, & Khan, N H. Air pollutant sulfur dioxide-induced alterations on the levels of lipids, lipid peroxidation and lipase activity in various regions of the rat brain. Denmark.
Haider, S S, Hasan, M, and Khan, N H. 1982. "Air pollutant sulfur dioxide-induced alterations on the levels of lipids, lipid peroxidation and lipase activity in various regions of the rat brain." Denmark.
@misc{etde_6563147,
title = {Air pollutant sulfur dioxide-induced alterations on the levels of lipids, lipid peroxidation and lipase activity in various regions of the rat brain}
author = {Haider, S S, Hasan, M, and Khan, N H}
abstractNote = {The exposure of rats to SO/sub 2/ (10 p.p.m.) for one hour daily for 30 days caused depletion of total lipids in all brain areas. The contents of phospholipid were elevated in cerebellum and brain stem, but were depleted in cerebral hemisphere. Cholesterol levels showed an increase in various brain regions. On the other hand, gangliosides were increased in cerebellum and brain stem, but were decreased in cerebral hemisphere. Interestingly, cholesterol/phospholipid ratio was increased in different regions of the brain. Lipase activity was elevated in cerebral hemisphere. Lipid peroxidation showed marked increment in whole brain and in all the brain areas studied. The results suggest that SO/sub 2/-exposure induces degradation of lipids. Interestingly, the lipid contents are affected differentially in the various parts of the brain.}
journal = {Acta Pharmacol. Toxicol.; (Denmark)}
volume = {51:1}
journal type = {AC}
place = {Denmark}
year = {1982}
month = {Jul}
}