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Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects

Abstract

Subcutaneous blood flow was measured preceding insulin-induced hypoglycaemia, at the onset of hypoglycaemic symptoms and 2 h later in juvenile diabetics with and without autonomic neuropathy and in normal males. In all groups subcutaneous blood flow decreased at the onset of hypoglycaemic symptoms compared with pre-hypoglycaemic flow. Two hours after onset of hypoglycaemic symptoms, subcutaneous blood flow was still significantly decreased compared with pre-hypoglycaemic flow. In normal subjects local nerve blockade had no effect on blood flow changes during hypoglycaemia, whereas local alpha-receptor blockade abolished the vasoconstrictor response. We suggest that circulating catecholamines stimulating vascular alpha-receptors are probably responsible for flow reduction in the subcutaneous tissue during hypoglycaemia.
Publication Date:
Aug 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-83-052422
Resource Relation:
Journal Name: Clin. Physiol.; (United Kingdom); Journal Volume: 2:4
Subject:
59 BASIC BIOLOGICAL SCIENCES; DIABETES MELLITUS; PATHOLOGY; BIOCHEMISTRY; BLOOD CHEMISTRY; BLOOD FLOW; GLUCOSE; INSULIN; PATIENTS; PHYSIOLOGY; SKIN; ALDEHYDES; BODY; CARBOHYDRATES; CHEMISTRY; DISEASES; ENDOCRINE DISEASES; HEXOSES; HORMONES; METABOLIC DISEASES; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; SACCHARIDES; 550900* - Pathology; 551000 - Physiological Systems
OSTI ID:
6562332
Research Organizations:
Hvidore Hospital, Copenhagen, Denmark
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CLPHD
Submitting Site:
HEDB
Size:
Pages: 323-332
Announcement Date:
Jan 01, 1983

Citation Formats

Hilsted, J, Madsbad, S, and Sestoft, L. Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects. United Kingdom: N. p., 1982. Web.
Hilsted, J, Madsbad, S, & Sestoft, L. Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects. United Kingdom.
Hilsted, J, Madsbad, S, and Sestoft, L. 1982. "Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects." United Kingdom.
@misc{etde_6562332,
title = {Subcutaneous blood flow during insulin-induced hypoglycaemia: studies in juvenile diabetics with and without autonomic neuropathy and in normal subjects}
author = {Hilsted, J, Madsbad, S, and Sestoft, L}
abstractNote = {Subcutaneous blood flow was measured preceding insulin-induced hypoglycaemia, at the onset of hypoglycaemic symptoms and 2 h later in juvenile diabetics with and without autonomic neuropathy and in normal males. In all groups subcutaneous blood flow decreased at the onset of hypoglycaemic symptoms compared with pre-hypoglycaemic flow. Two hours after onset of hypoglycaemic symptoms, subcutaneous blood flow was still significantly decreased compared with pre-hypoglycaemic flow. In normal subjects local nerve blockade had no effect on blood flow changes during hypoglycaemia, whereas local alpha-receptor blockade abolished the vasoconstrictor response. We suggest that circulating catecholamines stimulating vascular alpha-receptors are probably responsible for flow reduction in the subcutaneous tissue during hypoglycaemia.}
journal = []
volume = {2:4}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Aug}
}