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Axo-somatic synapses in the normal and X-irradiated dendate gyrus; factors affecting the density of afferent innervation

Journal Article:

Abstract

The density of synaptic input to the somata of dentate gyrus granule cells was examined utilizing quantitative electron microscopic techniques. In control (non-irradiated) material, greater numbers of axo-somatic synapses were observed in the superficial, earlier-generated cells as compared to the deep, later-generated cells. We further studied the X-irradiated dentate gyrus, in which the majority of granule cells were destroyed during postnatal genesis. The surviving cells displayed a density of innervation on their somata which exceeded that observed in either layer of the control material. These data are discussed in terms of the possible contribution of afferent-target cell interactions to the regulation of the density of synaptic innervation.
Authors:
Lee, K S; [1]  Gerbrandt, L; [2]  Lynch, G [3] 
  1. Max-Planck-Institut fuer Psychiatrie, Muenchen (Germany, F.R.)
  2. Neuroscience Research Program, Boston, MA (USA)
  3. California Univ., Irvine (USA)
Publication Date:
Oct 07, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-723869; EDB-83-052491
Resource Relation:
Journal Name: Brain Res.; (Netherlands); Journal Volume: 249:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NERVE CELLS; ONTOGENESIS; BIOLOGICAL RADIATION EFFECTS; BRAIN; CELL DIFFERENTIATION; LAYERS; PERINATAL IRRADIATION; PHYSIOLOGY; RATS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; IRRADIATION; MAMMALS; NERVOUS SYSTEM; ORGANS; RADIATION EFFECTS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987); 550300 - Cytology
OSTI ID:
6561870
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BRREA
Submitting Site:
HEDB
Size:
Pages: 51-56
Announcement Date:

Journal Article:

Citation Formats

Lee, K S, Gerbrandt, L, and Lynch, G. Axo-somatic synapses in the normal and X-irradiated dendate gyrus; factors affecting the density of afferent innervation. Netherlands: N. p., 1982. Web.
Lee, K S, Gerbrandt, L, & Lynch, G. Axo-somatic synapses in the normal and X-irradiated dendate gyrus; factors affecting the density of afferent innervation. Netherlands.
Lee, K S, Gerbrandt, L, and Lynch, G. 1982. "Axo-somatic synapses in the normal and X-irradiated dendate gyrus; factors affecting the density of afferent innervation." Netherlands.
@misc{etde_6561870,
title = {Axo-somatic synapses in the normal and X-irradiated dendate gyrus; factors affecting the density of afferent innervation}
author = {Lee, K S, Gerbrandt, L, and Lynch, G}
abstractNote = {The density of synaptic input to the somata of dentate gyrus granule cells was examined utilizing quantitative electron microscopic techniques. In control (non-irradiated) material, greater numbers of axo-somatic synapses were observed in the superficial, earlier-generated cells as compared to the deep, later-generated cells. We further studied the X-irradiated dentate gyrus, in which the majority of granule cells were destroyed during postnatal genesis. The surviving cells displayed a density of innervation on their somata which exceeded that observed in either layer of the control material. These data are discussed in terms of the possible contribution of afferent-target cell interactions to the regulation of the density of synaptic innervation.}
journal = {Brain Res.; (Netherlands)}
volume = {249:1}
journal type = {AC}
place = {Netherlands}
year = {1982}
month = {Oct}
}