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Assessment of the (/sup 14/C) aminopyrine breath test in liver disease

Journal Article:

Abstract

Different methods of performing the (/sup 14/C) aminopyrine breath test have been assessed. A tracer dose of 2 ..mu..Ci without a loading dose and with a single breath collection at two hours was the method selected, since it gave the best discrimination between patients with hepatocellular diseases and normal subjects (5.2 +- 0.2%, mean - SEM). Reduced values occurred in patients with chronic active hepatitis (with and without cirrhosis) (1.5 +- 0.2%), alcoholic cirrhosis (1.7 +- 0.4%) and hepatitis (2.5 +- 0.3%), and late primary biliary cirrhosis suggesting defective microsomal function with respect to demethylation. Normal results were common in early primary biliary cirrhosis. Two weeks of prednisolone therapy caused some improvement in the breath test in nine of ten patients with chronic active hepatitis. It is concluded that the (/sup 14/C) aminopyrine breath test is a simple test for detecting hepatocellular dysfunction, but has no obvious diagnostic advantage over the determination of serum aspartate transaminase and two hour post-prandial bile-acids.
Authors:
Galizzi, J; Long, R G; Billing, B H; Sherlock, S [1] 
  1. Royal Free Hospital, London (UK)
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-09-408034; EDB-79-022050
Resource Relation:
Journal Name: Gut; (United Kingdom); Journal Volume: 19:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON 14 COMPOUNDS; DIAGNOSTIC USES; HEPATITIS; DIAGNOSIS; LIVER CIRRHOSIS; AMINES; ANTIPYRINE; BREATH; EXHALATION; LIVER; LUNG CLEARANCE; MAN; METABOLISM; PATIENTS; PERFORMANCE; RADIONUCLIDE KINETICS; TRACER TECHNIQUES; ANALGESICS; ANIMALS; ANTIPYRETICS; AZOLES; BODY; CLEARANCE; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASES; DRUGS; EXCRETION; GLANDS; HETEROCYCLIC COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; PYRAZOLES; PYRAZOLINES; USES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
6542389
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: GUTTA
Submitting Site:
INIS
Size:
Pages: 40-45
Announcement Date:

Journal Article:

Citation Formats

Galizzi, J, Long, R G, Billing, B H, and Sherlock, S. Assessment of the (/sup 14/C) aminopyrine breath test in liver disease. United Kingdom: N. p., 1978. Web.
Galizzi, J, Long, R G, Billing, B H, & Sherlock, S. Assessment of the (/sup 14/C) aminopyrine breath test in liver disease. United Kingdom.
Galizzi, J, Long, R G, Billing, B H, and Sherlock, S. 1978. "Assessment of the (/sup 14/C) aminopyrine breath test in liver disease." United Kingdom.
@misc{etde_6542389,
title = {Assessment of the (/sup 14/C) aminopyrine breath test in liver disease}
author = {Galizzi, J, Long, R G, Billing, B H, and Sherlock, S}
abstractNote = {Different methods of performing the (/sup 14/C) aminopyrine breath test have been assessed. A tracer dose of 2 ..mu..Ci without a loading dose and with a single breath collection at two hours was the method selected, since it gave the best discrimination between patients with hepatocellular diseases and normal subjects (5.2 +- 0.2%, mean - SEM). Reduced values occurred in patients with chronic active hepatitis (with and without cirrhosis) (1.5 +- 0.2%), alcoholic cirrhosis (1.7 +- 0.4%) and hepatitis (2.5 +- 0.3%), and late primary biliary cirrhosis suggesting defective microsomal function with respect to demethylation. Normal results were common in early primary biliary cirrhosis. Two weeks of prednisolone therapy caused some improvement in the breath test in nine of ten patients with chronic active hepatitis. It is concluded that the (/sup 14/C) aminopyrine breath test is a simple test for detecting hepatocellular dysfunction, but has no obvious diagnostic advantage over the determination of serum aspartate transaminase and two hour post-prandial bile-acids.}
journal = {Gut; (United Kingdom)}
volume = {19:1}
journal type = {AC}
place = {United Kingdom}
year = {1978}
month = {Jan}
}