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Gamma irradiation of radioprotectant drugs. 1. Levamisole

Abstract

Levamisole ((S)-(-)-2,3,5,6-tetrahydro-6-phenyl-imidazo-(2, 1-b) thiazole), an immunomodulating drug and veterinary antihelminthic, is converted by tissues to a sulfhydryl derivative. The drug and its metabolite have mediating effects on lipid peroxidation in microsomal preparations. Because levamisole, as an inhibitor of lipid peroxidation, is a radioprotectant drug, it was of interest to study the response of the drug itself to ionizing radiation. Experiments were directed toward an examination of the effects of gamma radiation on aqueous solutions of levamisole. Chromatographic analysis (TLC) revealed two distinct groups of radiation products. Further separation and analysis of these groups by gas chromatography-mass spectrometry (GC-MS) demonstrated that each group of radiation products consists of several components, indicating that the gamma irradiation of non-deaerated solutions of levamisole gives rise to varying amounts of a multiproduct mixture, no constituent of which corresponds to the natural metabolite. Dose effect curves for the levamisole irradiation indicate that the drug is markedly resistant to molecular alteration under the experimental radiation conditions.
Authors:
Dobbs, C R; Elhardt, C E; May, L [1] 
  1. Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
Publication Date:
Sep 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-601714; EDB-81-058053
Resource Relation:
Journal Name: Radiat. Eff.; (United Kingdom); Journal Volume: 52:1-2
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; RADIOPROTECTIVE SUBSTANCES; RADIOLYSIS; AQUEOUS SOLUTIONS; G VALUE; GAMMA RADIATION; GAS CHROMATOGRAPHY; MASS SPECTROSCOPY; METABOLITES; MOLECULAR STRUCTURE; THIAZOLES; THIN-LAYER CHROMATOGRAPHY; THIOLS; AZOLES; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; CHEMISTRY; CHROMATOGRAPHY; DECOMPOSITION; DISPERSIONS; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; MIXTURES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; SEPARATION PROCESSES; SOLUTIONS; SPECTROSCOPY; 400600* - Radiation Chemistry
OSTI ID:
6535645
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: RAEFB
Submitting Site:
INIS
Size:
Pages: 91-94
Announcement Date:
May 01, 1981

Citation Formats

Dobbs, C R, Elhardt, C E, and May, L. Gamma irradiation of radioprotectant drugs. 1. Levamisole. United Kingdom: N. p., 1980. Web. doi:10.1080/00337578008210020.
Dobbs, C R, Elhardt, C E, & May, L. Gamma irradiation of radioprotectant drugs. 1. Levamisole. United Kingdom. doi:10.1080/00337578008210020.
Dobbs, C R, Elhardt, C E, and May, L. 1980. "Gamma irradiation of radioprotectant drugs. 1. Levamisole." United Kingdom. doi:10.1080/00337578008210020. https://www.osti.gov/servlets/purl/10.1080/00337578008210020.
@misc{etde_6535645,
title = {Gamma irradiation of radioprotectant drugs. 1. Levamisole}
author = {Dobbs, C R, Elhardt, C E, and May, L}
abstractNote = {Levamisole ((S)-(-)-2,3,5,6-tetrahydro-6-phenyl-imidazo-(2, 1-b) thiazole), an immunomodulating drug and veterinary antihelminthic, is converted by tissues to a sulfhydryl derivative. The drug and its metabolite have mediating effects on lipid peroxidation in microsomal preparations. Because levamisole, as an inhibitor of lipid peroxidation, is a radioprotectant drug, it was of interest to study the response of the drug itself to ionizing radiation. Experiments were directed toward an examination of the effects of gamma radiation on aqueous solutions of levamisole. Chromatographic analysis (TLC) revealed two distinct groups of radiation products. Further separation and analysis of these groups by gas chromatography-mass spectrometry (GC-MS) demonstrated that each group of radiation products consists of several components, indicating that the gamma irradiation of non-deaerated solutions of levamisole gives rise to varying amounts of a multiproduct mixture, no constituent of which corresponds to the natural metabolite. Dose effect curves for the levamisole irradiation indicate that the drug is markedly resistant to molecular alteration under the experimental radiation conditions.}
doi = {10.1080/00337578008210020}
journal = {Radiat. Eff.; (United Kingdom)}
volume = {52:1-2}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Sep}
}